Search results for "script"
showing 10 items of 5143 documents
Les manuscrits de l’époque romane dans les listes de livres des établissements bénédictins bourguignons (XIe-XIVe siècle)
2017
International audience
Reorganization of Nuclear Domain 10 Induced by Papillomavirus Capsid Protein L2
2002
AbstractNuclear domains (ND) 10 are associated with proteins implicated in transcriptional regulation, growth suppression, and apoptosis. We now show that the minor capsid protein L2 of human papillomavirus (HPV) type 33 induces a reorganization of ND10-associated proteins. Whereas the promyelocytic leukemia protein, the major structural component of ND10, was unaffected by L2, Sp100 was released from ND10 upon L2 expression. The total cellular amount of Sp100, but not of Sp100 mRNA, decreased significantly, suggesting degradation of Sp100. Proteasome inhibitors induced the dispersal of Sp100 and inhibited the nuclear translocation of L2. In contrast to Sp100, Daxx was recruited to ND10 by …
Heat shock and Cd2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 an…
2003
Nuclear domains called ND10 or PML bodies might function as nuclear depots by recruiting or releasing certain proteins. Although recruitment of proteins through interferon-induced upregulation and SUMO-1 modification level of PML had been defined, it is not known whether release of proteins is regulated and has physiological consequences. Exposure to sublethal environmental stress revealed a sequential release of ND10-associated proteins. Upon heat shock Daxx and Sp100 were released but PML remained, whereas exposure to subtoxic concentrations of CdCl2 induced the release of ND10-associated proteins, including PML, with Sp100 remaining in a few sites. In both cases,recovery times were simil…
A Mutually Stimulating Loop Involving Emx2 and Canonical Wnt Signalling Specifically Promotes Expansion of Occipital Cortex and Hippocampus
2005
The correct size of the different areas composing the mature cerebral cortex depends on the proper early allocation of cortical progenitors to their distinctive areal fates, as well as on appropriate subsequent tuning of their area-specific proliferation--differentiation profiles. Whereas much is known about the genetics of the former process, the molecular mechanisms regulating proliferation and differentiation rates within distinctive cortical proto-areas are still largely obscure. Here we show that a mutual stimulating loop, involving Emx2 and canonical Wnt signalling, specifically promotes expansion of the occipito-hippocampal anlage. Collapse of this loop occurring in Emx2 2/2 mutants …
Analysis of the written handover process during shift changes within the hospital
2008
This study assesses the ergonomic quality of a new writing format used for the written transmission of activity during a nurse’s handover in a hospital. This format called “targeted or focussed transmission” comes from a new prescription of hospital management designed to improve the written handover process. Our research focused on the information filtering process for each patient concerned by a shift handover. A three step methodology was designed, with the participation of 9 nurses in charge of 70 patients : (1) nursing work analysis before the handover, (2) oral handover analysis, (3) written handover analysis. Results show that the new writing format does not match the nurses’ needs t…
Demonstration Tasks for Assessment
2017
International audience; Learning from animations is conventionally measured using static assessment tools such as multiple choice tests or extended answer questions. These tools tend to rely heavily on textual information both for presenting the assessment items and as the medium for learner response. However, such assessments are not well aligned with the defining dynamic, pictorial characteristics of animated learning materials. This chapter considers the potential of demonstration tasks to offer more appropriate assessments of learning from animation. In these tasks, learners interact with a manipulable model of the animation’s subject matter to provide an explanatory account of how it c…
Commentary on Jakab's “Ineffability of Qualia”
2000
Zoltan Jakab has presented an interesting conceptual analysis of the ineffability of qualia in a functionalist and classical cognitivist framework. But he does not want to commit himself to a certain metaphysical thesis on the ontology of consciousness or qualia. We believe that his strategy has yielded a number of highly relevant and interesting insights, but still suffers from some minor inconsistencies and a certain lack of phenomenological and empirical plausibility. This may be due to some background assumptions relating to the theory of mental representation employed. Jakab's starting assumption is that there is no linguistic description of a given experience such that understanding t…
Putting information back into biological communication.
2010
At the heart of many debates on communication is the concept of information. There is an intuitive sense in which communication implies the transfer of some kind of information, probably the reason why information is an essential ingredient in most definitions of communication. However, information has also been an endless source of misunderstandings, and recent accounts have proposed that information should be dropped from a formal definition of communication. In this article, we re-evaluate the merits and the internal logic of information-based vs. information-free approaches and conclude that information-free approaches are conceptually incomplete and operationally hindered. Instead, we …
Identifying conserved genes involved in crop tolerance to cold stress
2022
Low temperature is a limiting factor for crop productivity in tropical and subtropical climates. Cold stress response in plants involves perceiving and relaying the signal through a transcriptional cascade composed of different transduction components, resulting in altered gene activity. We performed a meta-analysis of four previously published datasets of cold-tolerant and cold-sensitive crops to better understand the gene regulatory networks and identify key genes involved in cold stress tolerance conserved across phylogenetically distant species. Re-analysing the raw data with the same bioinformatics pipeline, we identified common cold tolerance-related genes. We found 236 and 242 common…
Characterization and Expression of Multiple Alternatively Spliced Transcripts of the Goodpasture Antigen Gene Region. Goodpasture Antibodies Recogniz…
1995
Collagen IV, the major component of basement membranes, is composed of six distinct alpha chains (alpha 1-alpha 6). Atypically among the collagen IV genes, the exons encoding the carboxyl-terminal region of the human alpha 3(IV) chain undergo alternative splicing. This region has been designated as the Goodpasture antigen because of its reactivity in the kidney and lung with the pathogenic autoantibodies causing Goodpasture syndrome. The data presented in this report demonstrate that, in human kidney, the gene region encompassing the Goodpasture antigen generates at least six alternatively spliced transcripts predicting five distinct proteins that differ in their carboxyl-terminus and retai…