Search results for "script"
showing 10 items of 5143 documents
An In Vitro Stereomicroscopic Evaluation of Bioactivity between Neo MTA Plus, Pro Root MTA, BIODENTINE & Glass Ionomer Cement Using Dye Penetrati…
2021
The ideal root end filling material should form a tight seal in the root canal by adhering to the cavity walls. Several materials have been used for root end filling. The present study aims to find out and compare the bioactivity of Neo MTA Plus, Pro Root MTA White, BIODENTINE & glass ionomer cement as root end filling materials using 1% methylene blue as tracer. Materials and methods: 80 extracted human permanent maxillary anterior teeth were used in the study. They were divided into four groups. Specimens were sectioned transversely in the cervical area to separate the crown from the root. The root canal was obturated with gutta percha and zinc oxide eugenol sealers. Thereafter, each …
Hub-Centered Gene Network Reconstruction Using Automatic Relevance Determination
2012
Network inference deals with the reconstruction of biological networks from experimental data. A variety of different reverse engineering techniques are available; they differ in the underlying assumptions and mathematical models used. One common problem for all approaches stems from the complexity of the task, due to the combinatorial explosion of different network topologies for increasing network size. To handle this problem, constraints are frequently used, for example on the node degree, number of edges, or constraints on regulation functions between network components. We propose to exploit topological considerations in the inference of gene regulatory networks. Such systems are often…
Global injury morbidity and mortality from 1990 to 2017 : results from the Global Burden of Disease Study 2017
2020
Publisher's version (útgefin grein)
"Understand and be understood" : English pronunciation teaching in Finnish upper secondary schools assessed by university students of English
2016
Vaatimukset englannin kielen monipuoliselle osaamiselle ovat kasvaneet muun muassa kansainvälistyvässä työelämässä. Sen vaikutukset ulottuvat myös jokapäiväiseen elämäämme: englanti näkyy ja kuuluu kaikkialla. Tämä asettaa koulutukselle paineita tuottaa yhteiskuntaan kielellisesti päteviä osaajia ja yhtenä lukion opetussuunnitelman kieltenopetuksen tavoitteena onkin laaja kommunikatiivinen kielitaito. Suullisten taitojen arvostus ei ole kuitenkaan juuri näkynyt käytännössä kielten kurssisisällöissä; suurena syynä tähän on suullisen osuuden puuttuminen kielten ylioppilaskokeista. Suomessa sekä englannin ääntämisen opetus että sen tutkiminen ovat jääneet vähemmälle huomiolle. Tämän tutkielman…
EGFL7 ligates αvβ3 integrin to enhance vessel formation
2013
Angiogenesis, defined as blood vessel formation from a preexisting vasculature, is governed by multiple signal cascades including integrin receptors, in particular integrin αVβ3. Here we identify the endothelial cell (EC)-secreted factor epidermal growth factor-like protein 7 (EGFL7) as a novel specific ligand of integrin αVβ3, thus providing mechanistic insight into its proangiogenic actions in vitro and in vivo. Specifically, EGFL7 attaches to the extracellular matrix and by its interaction with integrin αVβ3 increases the motility of EC, which allows EC to move on a sticky underground during vessel remodeling. We provide evidence that the deregulation of EGFL7 in zebrafish embryos leads …
University students' attitudes towards phonemic transcription as a teaching method : a survey of English students
2017
Foneeminen tarkekirjoitus on pitkään ollut osa ääntämisen opetusta. Se on ainut tapa, jolla sanojen ja puhunnosten ääntämisasuun voidaan viitata ilman tulkinnanvaraa, ja lisäksi yksi harvoista visuaalisista apuvälineistä, jotka soveltuvat erityisesti ääntämisen opetukseen. Foneemisessa tarkekirjoituksessa käytetään kansainvälisen foneettisen aakkoston (IPA) symboleja. Tämän tutkimuksen aiheena on englannin kielen opettajaopiskelijoiden asenteet foneemista tarkekirjoitusta kohtaan oppimisvälineenä. Tutkimuksen päätavoitteena on selvittää, kuinka paljon ja millä tavoilla opiskelijat kokevat hyötyneensä foneemisen tarkekirjoituksen opiskelusta ääntämyksen opiskelussa. Lisäksi pyritään selvittä…
The role of prognostic stratification on prescription of anticoagulants in older patients with atrial fibrillation : a multicenter, observational, pr…
2022
Background: Literature suggests that different risks of mortality could influence physicians in prescribing or not anticoagulants in older patients with atrial fibrillation (AF). The Multidimensional Prognostic Index (MPI) can be considered a tool for the detection of multidimensional frailty. The aim of this cross-sectional study was to evaluate whether prescription patterns of oral anticoagulants exist, based on MPI values. Methods: Older hospitalised patients (age >= 65 years) with non-valvular AF were included across 24 European centres. MPI was calculated using validated and standardised tools derived from a comprehensive geriatric assessment. Other functional and clinical information …
Transcriptome analysis of Pseudomonas mediterranea and P. corrugata plant pathogens during accumulation of medium-chain-length PHAs by glycerol bioco…
2017
Pseudomonas corrugata and P. mediterranea are soil inhabitant bacteria, generally living as endophytes on symptomless plants and bare soil, but also capable of causing plant diseases. They share a similar genome size and a high proteome similarity. P. corrugata produces many biomolecules which play an important role in bacterial cell survival and fitness. Both species produce different medium-chain-length PHAs (mcl-PHAs) from the bioconversion of glycerol to a transparent film in P. mediterranea and a sticky elastomer in P. corrugata. In this work, using RNA-seq we investigated the transcriptional profiles of both bacteria at the early stationary growth phase with glycerol as the carbon sou…
Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activa…
2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive human HCC for macroH2A1 and CD44 CSC marker expression. We also knocked down (KD) macroH2A1 in HCC cells, and performed integrated transcriptomic and secretomic analyses. Results: Human HCC showed low macroH2A1 and high CD44 expression compared to control tissues. MacroH2A1 KD CSC-like cells transferred paracrinally their chemoresistant properties to parental HCC cells. MacroH2A1 KD conditioned media transcriptionally reprogrammed parental …
Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet.
2015
Contains fulltext : 155347.pdf (Publisher’s version ) (Closed access) BACKGROUND/OBJECTIVES: In the context of obesity, epigenetic mechanisms regulate cell-specific chromatin plasticity, perpetuating gene expression responses to nutrient excess. MacroH2A1, a variant of histone H2A, emerged as a key chromatin regulator sensing small nutrients during cell proliferation and differentiation. Mice genetically ablated for macroH2A1 (knockout (KO)) do not show overt phenotypes under a standard diet. Our objective was to analyse the in vivo role of macroH2A1 in response to nutritional excess. METHODS: Twelve-week-old whole-body macroH2A1 KO male mice were given a high-fat diet (60% energy from lard…