Search results for "script"
showing 10 items of 5143 documents
Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD.
2014
Background In models of COPD, environmental stressors induce innate immune responses, inflammasome activation and inflammation. However, the interaction between these responses and their role in driving pulmonary inflammation in stable COPD is unknown. Objectives To investigate the activation of innate immunity and inflammasome pathways in the bronchial mucosa and bronchoalveolar lavage (BAL) of patients with stable COPD of different severity and control healthy smokers and non-smokers. Methods Innate immune mediators (interleukin (IL)-6, IL-7, IL-10, IL-27, IL-37, thymic stromal lymphopoietin (TSLP), interferon γ and their receptors, STAT1 and pSTAT1) and inflammasome components (NLRP3, NA…
Primary culture of avian embryonic heart forming region cells to study the regulation of vertebrate early heart morphogenesis by vitamin A
2014
Background: Important knowledge about the role of vitamin A in vertebrate heart development has been obtained using the vitamin A-deficient avian in ovo model which enables the in vivo examination of very early stages of vertebrate heart morphogenesis. These studies have revealed the critical role of the vitamin A-active form, retinoic acid (RA) in the regulation of several developmental genes, including the important growth regulatory factor, transforming growth factor-beta2 (TGFβ2), involved in early events of heart morphogenesis. However, this in ovo model is not readily available for elucidating details of molecular mechanisms determining RA activity, thus limiting further examination o…
Directors' stress in day care centers : related factors and coping strategies
2020
PurposeThis study aims to explore what causes stress to day care center directors and what their coping strategies are. In addition, the study examined the extent to which directors experience work-related stress and burnout, and the factors associated with their work-related stress, engagement and recovery from work.Design/methodology/approachA mixed method approach was used.FindingsThe results showed that the main sources of directors' stress were connected to leading oneself, leading others, managing change and lack of social support. Moreover, the main coping strategies with stress were leading oneself, social support and leading others. In addition, both pre- and in-service leadership …
Análisis de publicaciones sobre alfabetización inicial desde una perspectiva didáctica
2020
En este trabajo se elabora una revisión sistemática de estudios sobre la aproximación a la lengua escrita en Educación Infantil en España. Se consideran estudios publicados entre 2009 y 2019 que se centren en los procesos de enseñanza y aprendizaje en aula para conocer y analizar las prácticas docentes que se difunden desde la investigación. Los resultados permiten, por un lado, describir el tipo de investigaciones: predominio de estudios realizados en aula sobre los de carácter experimental o revisión bibliográfica; equilibrio entre investigación cuantitativa y cualitativa o mayor atención al periodo 3-6 años. Por otro lado, los datos muestran que las publicaciones científicas recogen vari…
Avisos y relaciones manuscritos y impresos sobre catastrofes naturales y sucesos prodigiosos en Sicilia durante el siglo XVIII
2021
In the eighteenth century there is a large number of stories, both handwritten and in print, that describe extraordinary and unlucky events of different kinds: monstrosities, eclipses, or storms, floods, earthquakes, eruptions, etc. These stories, with respect to Sicily, take the form of occasional printed news, although sometimes they may be included in serials organized by different criteria (topographic/chronological/subject). Surviving documents in archives and libraries offer some opportunities to deepen the study of issues concerning the circulation and dissemination of news about the same event, their credibility, their formal characters and content. Very rare printed ephemera and ha…
Retail Evolution in Eastern European Countries: An Overview
2020
Retail has evolved a lot in the last years. Still, compared to more mature markets (such as US, UK, Germany, France, Sweden, the Netherlands), retail in Eastern European countries is less developed, with more balanced supply and demand. According to GfK’s report on European Retail in 2018, in 2017 there was a slight increase (+1.9 percent) in the purchasing power within the European Union (EU28) countries, Romania having the biggest increase (+7.8 percent) [1]. However, Romania’s low per capita purchasing power shows a gap in wealth levels across Europe. Huge differences between Western and Eastern Europe are visible also in terms of per capita values for retail space. Thus, the purpose of …
Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster.
2001
Abstract The first step in ecdysteroidogenesis, i.e. the 7,8-dehydrogenation of dietary cholesterol (C) to 7-dehydrocholesterol (7dC), is blocked in Drosophila melanogaster homozygous woc (without children) third instar larval ring glands (source of ecdysone). Unlike ring glands from wild-type D. melanogaster larvae, glands from woc mutants cannot convert radiolabelled C or 25-hydroxycholesterol (25C) to 7dC or 7-dehydro-25-hydroxycholesterol (7d25C) in vitro, nor to ecdysone (E). Yet, when these same glands are incubated with synthetic tracer 7d25C, the rate of metabolism of this polar Δ5,7-sterol into E is identical to that observed with glands from comparably staged wild-type larvae. The…
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
2020
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in‐house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV…
A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins
2018
Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The Europea…
The integration of social and neural synchrony: a case for ecologically valid research using MEG neuroimaging
2020
Abstract The recent decade has seen a shift from artificial and environmentally deprived experiments in neuroscience to real-life studies on multiple brains in interaction, coordination and synchrony. In these new interpersonal synchrony experiments, there has been a growing trend to employ naturalistic social interactions to evaluate mechanisms underlying synchronous neuronal communication. Here, we emphasize the importance of integrating the assessment of neural synchrony with measurement of nonverbal behavioral synchrony as expressed in various social contexts: relaxed social interactions, planning a joint pleasurable activity, conflict discussion, invocation of trauma, or support giving…