Search results for "script"
showing 10 items of 5143 documents
SINGING THE SELF: THE AUTOBIOGRAPHY OF THE FIFTEENTH-CENTURY GERMAN SINGER AND COMPOSER JOHANNES VON SOEST
2010
The German singer, composer and writer Johannes von Soest (1448–1506), also referred to as Steinwart or Steinwert, is the author of a vernacular autobiography in verse. One of the very few such documents written by a musician, it gives a highly personal insight into his career, which extended from his training as a chorister in Soest to the ducal chapel in Cleves and afterwards to Bruges (in the company of two unnamed English musicians), Aardenburg (Overijssel), Maastricht, possibly Cologne, Kassel and finally Heidelberg, where he was appointed as Kapellmeister. He subsequently decided to become a physician. The article includes a complete transcription of the text, whose original was destr…
RNA sequencing-based transcriptome profiling of cardiac tissue Implicados novela putative disease mechanisms in FLNC-associated arrhythmogenic cardio…
2020
Arrhythmogenic cardiomyopathy (ACM) encompasses a group of inherited cardiomyopathies including arrhythmogenic right ventricular cardiomyopathy (ARVC) whose molecular disease mechanism is associated with dysregulation of the canonical WNT signalling pathway. Recent evidence indicates that ARVC and ACM caused by pathogenic variants in the FLNC gene encoding filamin C, a major cardiac structural protein, may have different molecular mechanisms of pathogenesis. We sought to identify dysregulated biological pathways in FLNC-associated ACM. RNA was extracted from seven paraffin-embedded left ventricular tissue samples from deceased ACM patients carrying FLNC variants and sequenced. Transcript le…
Family influence on firm performance: Finnish publicly held family firm perspective
2011
The study aims at examining the effect of family influence on firm performance. An empirical focus is put on comparison of return on investment of publicly held family and non family firms in Finland. The income statement and balance sheet data of the companies covers the years 2000–2005. The study shows that families are present in 25% of the companies listed on the OMX Helsinki, Finland Stock Exchange. The data indicates that publicly held family firms create close the same value added per employee than non-family firms. According to the results, family firms are less indebted and perform slightly better than non-family firms measured by return on investment. The observations of the study…
FPGA-based embedded Logic Controllers
2014
In general case, reconfigurable logic controllers (RLC) are included into reactive digital embedded systems, carrying out control for several processes proceeding concurrently. The paper presents a practical application of a formal, rule-based specification language in Gentzen sequent logic, which is used as an intermediate textual description of a control interpreted Petri net. On the other hand exactly the same description serves also as logic design expressions, related with different versions of functionally equivalent concurrent state machine models, considered on Register Transfer Level. The symbolic rule-based specification of Petri net-based embedded Logic Controllers (LCs) can be s…
Evaluating the Hypoxia Response of Ruffe and Flounder Gills by a Combined Proteome and Transcriptome Approach
2015
Hypoxia has gained ecological importance during the last decades, and it is the most dramatically increasing environmental factor in coastal areas and estuaries. The gills of fish are the prime target of hypoxia and other stresses. Here we have studied the impact of the exposure to hypoxia (1.5 mg O2/l for 48 h) on the protein expression of the gills of two estuarine fish species, the ruffe (Gymnocephalus cernua) and the European flounder (Platichthys flesus). First, we obtained the transcriptomes of mixed tissues (gills, heart and brain) from both species by Illumina next-generation sequencing. Then, the gill proteomes were investigated using two-dimensional gel electrophoresis and mass sp…
Nanog Regulates Primordial Germ Cell Migration Through Cxcr4b
2010
Abstract Gonadal development in vertebrates depends on the early determination of primordial germ cells (PGCs) and their correct migration to the sites where the gonads develop. Several genes have been implicated in PGC specification and migration in vertebrates. Additionally, some of the genes associated with pluripotency, such as Oct4 and Nanog, are expressed in PGCs and gonads, suggesting a role for these genes in maintaining pluripotency of the germ lineage, which may be considered the only cell type that perpetually maintains stemness properties. Here, we report that medaka Nanog (Ol-Nanog) is expressed in the developing PGCs. Depletion of Ol-Nanog protein causes aberrant migration of …
Nanog Regulates Proliferation During Early Fish Development
2009
Abstract Nanog is involved in controlling pluripotency and differentiation of stem cells in vitro. However, its function in vivo has been studied only in mouse embryos and various reports suggest that Nanog may not be required for the regulation of differentiation. To better understand endogenous Nanog function, more animal models should be introduced to complement the murine model. Here, we have identified the homolog of the mammalian Nanog gene in teleost fish and describe the endogenous expression of Ol-Nanog mRNA and protein during medaka (Oryzias latipes) embryonic development and in the adult gonads. Using medaka fish as a vertebrate model to study Nanog function, we demonstrate that …
New Flexible Probability Distributions for Ranking Data
2015
Recently, several models have been proposed in literature for analyzing ranks assigned by people to some object. These models summarize the liking feeling for this object, possibly also with respect to a set of explanatory variables. Some recent works have suggested the use of the Shifted Binomial and of the Inverse Hypergeometric distribution for modelling the approval rate, while mixture models have been developed for taking into account the uncertainty of the ranking process. We propose two new probabilistic models, based on the Discrete Beta and the Shifted-Beta Binomial distributions, that ensure much flexibility and allow the joint modelling of the scale (approval rate) and the shape …
Computer-supported collaboration in a scripted 3-D game environment
2005
The particular focus of this paper is on scripting collaboration in a 3-D virtual game environment intended to make learning more effective, but also take into account the risk of over-scripting learning. The empirical experiment eScape, which encourages learners to solve problems collaboratively, is also presented. This study attempts to find out whether the features of 3-D games can be used to create meaningful scripted collaborative learning environments. The results indicated that scripting persuaded student teams to enter into collaboration, but the actual processes varied.
Fiktiiviset reseptit ja mahdottomat ateriat kirjallisen komiikan lajina
2017
Fictitious recipes, impossible meals: a subgenre of comical literature The article looks into ctitious and imaginative food recipes and comical potentiality of such food related text types as listings of ingredients, foodstuffs, dishes, or portions. The focus is on imaginary, fantastic, and impossible meals and recipes: portions that could not be implemented in the real world. The recipe as a form is covered from genre-theoretical, narratological, poetic and procedural perspectives. The special point of reference is experimental literature and its interests in literary forms, rules, constraints, and procedures − the terms that could be used to define also culinary recipes as codes or script…