Search results for "script"
showing 10 items of 5143 documents
Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer.
2017
Biological changes that occur during metastatic progression of breast cancer are still incompletely characterized. In this study, we compared intrinsic molecular subtypes and gene expression in 123 paired primary and metastatic tissues from breast cancer patients. Intrinsic subtype was identified using a PAM50 classifier and χ2 tests determined the differences in variable distribution. The rate of subtype conversion was 0% in basal-like tumors, 23.1% in HER2-enriched (HER2-E) tumors, 30.0% in luminal B tumors, and 55.3% in luminal A tumors. In 40.2% of cases, luminal A tumors converted to luminal B tumors, whereas in 14.3% of cases luminal A and B tumors converted to HER2-E tumors. We ident…
Direct In Vitro Reprogramming of Astrocytes into Induced Neurons
2021
Spontaneous neuronal replacement is almost absent in the postnatal mammalian nervous system. However, several studies have shown that both early postnatal and adult astroglia can be reprogrammed in vitro or in vivo by forced expression of proneural transcription factors, such as Neurogenin-2 or Achaete-scute homolog 1 (Ascl1), to acquire a neuronal fate. The reprogramming process stably induces properties such as distinctly neuronal morphology, expression of neuron-specific proteins, and the gain of mature neuronal functional features. Direct conversion of astroglia into neurons thus possesses potential as a basis for cell-based strategies against neurological diseases. In this chapter, we …
Alla ricerca della sicurezza e della qualità: il modello di miglioramento dell'Oncologia Medica nel Policlinico Universitario di Palermo
2015
[In search of safety and quality: the improvement model proposed by the Oncology Department of the Palermo University] Over the past 20 years the field of oncology has product therapeutic innovations that have radically changed the prognosis of the most prevalent malignancies, since introduction of so-called targeted molecular agents. As a result of these changes, also the management of cancer patients has become more complex requiring technologies and skills that involve many professionals (medical oncologists, biologists, molecular geneticists, surgeons, pathologists, radiologists, nurses and psychologists), each engaged in a different stage of the disease, with the common goal of ensurin…
Pequeña y mediana empresa en el mundo rural medieval. Formas de organización de la producción. Ejemplos del País Valenciano (s. XV)
2020
El presente estudio analiza el concepto empresa aplicado al periodo medieval, e intenta un mínimo recorrido historiográfico por aquellos autores que se han acercado a la «Business History». Además intenta una reconstrucción de los distintos tipos de empresa manufacturera en un ámbito rural que se nos muestra cada vez más dinámico, pero poco estudiado todavía por parte de los historiadores interesados en el mundo del artesanado y de la industria. Se estudian las distintas formas de organización de la producción que condicionan los diferentes modos de gestión de la empresa manufacturera tomando como referencia el espacio valenciano. This article analyses the concept of «enterprise» as applied…
The Pomar Codex (ca, 1590): plants and animals of the old world and from the Hernandez expedition to America.
1992
Abstract<title> RIASSUNTO </title>Si descrive un codice illustrato (ca. 1590), donato dal re Filippo II a Honorato Pomar, professore di medicina botanica all'Università di Valencia, e ora conservato nella biblioteca della stessa universita. Tale codice contiene 218 acquarelli di piante e animali del Vecchio Continente e provenienti dalla spedizione nelle Americhe di Hernandez (1571-1577). Inoltre, l'articolo si sofferma brevemente sull'interesse di Filippo II per la storia naturale, sulla spedizione di Hernandez e sulla cattedra di botanica medica all'universita di Valencia nel corso del sedicesimo secolo. Infine, si discute dell'identita dell'autore delle illustrazioni e dei te…
De Platonis "Parmenidis" codicibus quaestiones
2021
Si fa un censimento completo dei manoscritti che contengono il "Parmenide" di Platone e se ne definiscono i rapporti, proponendo innovazioni e integrazioni rispetto agli studi di C. Moreschini (1965-66). A complete census is made of the manuscripts that contain Plato's "Parmenides" and their relationships are defined, proposing innovations and additions with respect to the studies of C. Moreschini (1965-66).
La tradizione manoscritta del centone di Proba
2014
La participación de la Universitat de València en el proyecto Europeana Regia
2013
En este artículo se describe la participación de la Universitat de València en el proyecto Europeana Regia: biblioteca digital de manuscritos medievales y renacentistas, coordinado por la Bibliothèque Nationale de France y cofinanciado por la Comisión Europea. También se detalla la integración del proyecto dentro de los objetivos de la institución: la creación de una colección digital propia destinada a la investigación y la incorporación de los manuscritos digitalizados en el repositorio institucional. Se describen los resultados teóricos y prácticos del proyecto: work packages, página web etc. Finalmente se detalla cómo un año después de ejecutado el proyecto los manuscritos de la Univers…
Marine data collection and transmission system for ECO-boat
2014
Masteroppgave i Informasjons- og kommunikasjonsteknologi IKT590 Universitetet i Agder 2014 Marine data collection is of great importance because the analytical results based onthe collected data can be utilized for many purposes during the design phase beforesale as well as the maintenance phase of the boat after sale. In this thesis, I havedesigned and implemented a marine data collection and transmission system foryachts. The system can collect data from an NMEA network, a wireless sensornetwork, a custom-made CAN-bus network, and other sensors such as a 9degree-of-freedom inertial measurement units. The collected data is stored both atthe boat and at a remote server. In this design, I us…
Does incremental and radical innovation performance depend on different types of knowledge accumulation capabilities and organizational size?
2016
While prior studies recognize the importance of knowledge accumulation capabilities in innovation performance, current research has still failed to empirically identify its role with regard to different types of innovation performance. The objective of this paper is to address this knowledge gap and to explore the relationships between internal knowledge creation and absorptive capabilities, and incremental and radical innovation performance. The study also contributes to analyzing the complex effect that organizational size has in the whole innovation process, influencing its antecedents (internal knowledge creation capability and absorptive capability) as well as its outputs (incremental …