Search results for "script"

Reactive Powder Concrete Containing Basalt Fibers: Strength, Abrasion and Porosity

2020

The paper presents the test results of basalt fiber impact on a compressive and flexural strength, resistance to abrasion and porosity of Reactive Powder Concrete (RPC). The reasons for testing were interesting mechanical properties of basalt fibers, the significant tensile strength and flexural strength, and in particular the resistance to high temperatures, as well as a relatively small number of RPC tests performed with those fibers and different opinions regarding the impact of those fibers on concrete strength. The composition of the concrete mix was optimized to obtain the highest packing density of particles in the composite, based on the optimum particle size distribution curve acc.…

Optimal control circuitry design for the digital p53 dynamics in cancer cell and apoptosis

2009

AbstractExperimental work and theoretical models deduce a "digital" response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in feedback. This paper proposes an aerospace architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is not to improve the analysis of the actual mathematical models but to demonstrate the usefulness of such digital circuitry design capable to predict and detect the …

A Simple Metaheuristic for the FleetSize and Mix Problem with TimeWindows

2017

This paper presents a powerful new single-parameter metaheuristic to solve the Fleet Size and Mix Vehicle Routing Problem with Time Windows. The key idea of the new metaheuristic is to perform a random number of random-sized jumps in random order through four well-known local search operators. Computational testing on the 600 large-scale benchmarks of Bräysy et al. (Expert Syst Appl 36(4):8460–8475, 2009) show that the new metaheuristic outperforms previous best approaches, finding 533 new best-known solutions. Despite the significant number of random components, it is demonstrated that the variance of the results is rather low. Moreover, the suggested metaheuristic is shown to scale almost…

Spatial Besov regularity for stochastic partial differential equations on Lipschitz domains

2010

We use the scale of Besov spaces B^\alpha_{\tau,\tau}(O), \alpha>0, 1/\tau=\alpha/d+1/p, p fixed, to study the spatial regularity of the solutions of linear parabolic stochastic partial differential equations on bounded Lipschitz domains O\subset R^d. The Besov smoothness determines the order of convergence that can be achieved by nonlinear approximation schemes. The proofs are based on a combination of weighted Sobolev estimates and characterizations of Besov spaces by wavelet expansions.

Genomic run-on evaluates transcription rates for all yeast genes and identifies gene regulatory mechanisms

2004

Most studies of eukaryotic gene regulation have been done looking at mature mRNA levels. Nevertheless, the steady-state mRNA level is the result of two opposing factors: transcription rate (TR) and mRNA degradation. Both can be important points to regulate gene expression. Here we show a new method that combines the use of nylon macroarrays and in vivo radioactive labeling of nascent RNA to quantify TRs, mRNA levels, and mRNA stabilities for all the S. cerevisiae genes. We found that during the shift from glucose to galactose, most genes undergo drastic changes in TR and mRNA stability. However, changes in mRNA levels are less pronounced. Some genes, such as those encoding mitochondrial pro…

UML-Based Metamodeling for Information System Engineering and Evolution

2003

In modelers’ practice metamodels have become the core of UML-based metamodeling environments: metamodels form the basis of application domain descriptions, and they are instantiated into models. In the context of information system engineering and interoperability, we have developped two operations on metamodels: metamodel integration and measure of semantical distance between metamodels. In this paper, we explore application of these operations to information systems’ evolution.

Fractional differential equations and related exact mechanical models

2013

Creep and relaxation tests, performed on various materials like polymers, rubbers and so on are well-fitted by power-laws with exponent β ∈ [0, 1] (Nutting (1921), Di Paola et al. (2011)). The consequence of this observation is that the stress-strain relation of hereditary materials is ruled by fractional operators (Scott Blair (1947), Slonimsky (1961)). A large amount of researches have been performed in the second part of the last century with the aim to connect constitutive fractional relations with some mechanical models by means of fractance trees and ladders (see Podlubny (1999)). Recently, Di Paola and Zingales (2012) proposed a mechanical model that corresponds to fractional stress-…

Impact of physicians’ participation in non-interventional post-marketing studies on their prescription habits: A retrospective 2-armed cohort study i…

2020

Background Non-interventional post-marketing studies (NIPMSs) sponsored by pharmaceutical companies are controversial because, while they are theoretically useful instruments for pharmacovigilance, some authors have hypothesized that they are merely marketing instruments used to influence physicians’ prescription behavior. So far, it has not been shown, to our knowledge, whether NIPMSs actually do have an influence on prescription behavior. The objective of this study was therefore to investigate whether physicians’ participation in NIPMSs initiated by pharmaceutical companies has an impact on their prescription behavior. In addition, we wanted to analyze whether specific characteristics of…

A new perspective on CMS – testing the effect of camera displacement in a realistic lane-change task

2020

Administrative Decisions in the Era of Artificial Intelligence

2020

The rapid development of cybernetics allows the use of artificial intelligence in many areas of social and economic life. The State can also harness algorithms and machine learning for its actions. Automatic decision making should be one of the stages in the development and improvement of public administration. While it is easy to implement these solutions in the case of related decisions, decisions made under administrative discretion, general clauses or valuation standards pose a challenge. The correct transformation of paper-based public administration into automatic public administration requires a change in decision makers’ thinking, the introduction of new solutions, and building trus…