Search results for "script"
showing 10 items of 5143 documents
NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells.
2013
The incidence of pancreatic adenocarcinoma is increasing with more than 43,000 predicted new cases in the US and 65,000 in Europe this year. Pancreatic cancer patients have a short life expectancy with less than 3–4% 5-y survival, which results in an equivalent incidence and mortality rate. One of the major challenges in pancreatic cancer is the identification of pharmacological approaches that overcome the resistance of this cancer to therapy. Intensive research in the past decades has led to the classification of pancreatic cancers and the identification of the driver key genetic events. Despite the advances in understanding the molecular mechanisms responsible for pancreatic cancer patho…
Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers
2021
Abstract The clinical relevance of comprehensive molecular analysis in rare cancers is not established. We analyzed the molecular profiles and clinical outcomes of 1,310 patients (rare cancers, 75.5%) enrolled in a prospective observational study by the German Cancer Consortium that applies whole-genome/exome and RNA sequencing to inform the care of adults with incurable cancers. On the basis of 472 single and six composite biomarkers, a cross-institutional molecular tumor board provided evidence-based management recommendations, including diagnostic reevaluation, genetic counseling, and experimental treatment, in 88% of cases. Recommended therapies were administered in 362 of 1,138 patient…
Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity
2019
Background: In patients with NAFLD liver biopsy is the gold standard to detect NASH and stage liver fibrosis. We aimed to identify differentially expressed mRNAs and non-coding RNAs in serum samples of biopsy-diagnosed mild and severe NAFLD patients with respect to controls and to each other. Methods: We first performed a whole transcriptome analysis through microarray (n=12: 4 CTRL; 4 mild NAFLD: NAS≤4 F0; 4 severe NAFLD NAS≥5 F3), followed by validation of selected transcripts through qPCRs in 88 subjects: 63 NAFLD, 25 CTRL. A similar analysis was also performed on HepG2 exposed to Oleate:Palmitate or only Palmitate (cellular model of NAFL/NASH) at intracellular/extracellular levels. Tran…
Impact of BCR-ABL1 Transcript Type on Response, Treatment-Free Remission Rate and Survival in Chronic Myeloid Leukemia Patients Treated with Imatinib
2021
Chronic myeloid leukemia; BCR-ABL1 transcripts; Response to imatinib Leucemia mieloide crónica; Transcripciones de BCR-ABL1; Respuesta al imatinib Leucèmia mieloide crònica; Transcripcions BCR-ABL1; Resposta a imatinib The most frequent BCR-ABL1-p210 transcripts in chronic myeloid leukemia (CML) are e14a2 and e13a2. Imatinib (IM) is the most common first-line tyrosine–kinase inhibitor (TKI) used to treat CML. Some studies suggest that BCR-ABL1 transcript types confer different responses to IM. The objective of this study was to correlate the expression of e14a2 or e13a2 to clinical characteristics, cumulative cytogenetic and molecular responses to IM, acquisition of deep molecular response …
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study.
2006
Item does not contain fulltext BACKGROUND: Loss of TP53 function through gene mutation is a critical event in the development and progression of many tumour types including colorectal cancer (CRC). In vitro studies have found considerable heterogeneity amongst different TP53 mutants in terms of their transactivating abilities. The aim of this work was to evaluate whether TP53 mutations classified as functionally inactive (< or=20% of wildtype transactivation ability) had different prognostic and predictive values in CRC compared with mutations that retained significant activity. MATERIALS AND METHODS: TP53 mutations within a large, international database of CRC (n = 3583) were classified ac…
Revealing Employer’s Name in Social Networks
2017
Abstract The research investigates the question of the importance of mentioning the name of the employer in online and offline social networks. The exchange of information is an important part of social networks and social capital theory. Companies can use the networks of their employees to recruit new hires and to check habits and interests of likely new employees. To do that, the employee has to mention the name of the company in these social networks. The paper compares different real social networks used by family and friends and private and business social network sites (SNSs) as online social networks and compares the differences between men and women. The empirical research has been …
Ontology mapping specification in description logics for cooperative systems
2006
Le developpement rapide du Web semantique est lie a la specification de plus en plus d'ontologies. Celles-ci permettent de modeliser des connaissances agreees par des communautes de personnes concernant des domaines ou des tâches specifiques. Le meme domaine decrit par deux communautes distinctes sera modelise de facon differente. Les systemes cooperatifs visent a rendre les informations provenant de differentes sources disponibles au-dela de leurs divergences. Pour cela, ils doivent aligner, fusionner ou integrer ces ontologies. La decouverte de mappings est un point cle dans la resolution efficace des heterogeneites entre ontologies. Nous developpons une architecture qui connecte des syst…
Modeling Changes for SHOIN(D) Ontologies: An Exhaustive Structural Model
2013
Ontology development starts with a rigorous ontological analysis that provides a conceptualization of the domain to model agreed by the community. An ontology, specified in a formal language, approximates the intended models of this conceptualization. It needs then to be revised and refined until an ontological commitment is found. Also ulterior updates, responding to changes in the domain and/or the conceptualization, are expected to occur throughout the ontology life cycle. To handle a consistent application of changes, a couple of ontology evolution methodologies have been proposed. Maintaining the structural consistency is one of the ontology evolution criteria. It implies modeling chan…
Model Driven Specification of Ontology Translations
2008
The alignment of different ontologies requires the specification, representation and execution of translation rules. The rules need to integrate translations at the lexical, the syntactic and the semantic layer requiring semantic reasoning as well as low-level specification of ad-hoc conversions of data. Existing formalisms for representing translation rules cannot cover the representation needs of these three layers in one model. We propose a metamodel-based representation of ontology alignments that integrate semantic translations using description logics and lower level translation specifications into one model of representation for ontology alignments.
Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes
2013
BACKGROUND: The cumulus cells (CCs) enveloping antral and ovulated oocytes have been regarded as putative source of non-invasive markers of the oocyte developmental competence. A number of studies have indeed observed a correlation between CCs gene expression, embryo quality, and final pregnancy outcome. Here, we isolated CCs from antral mouse oocytes of known developmental incompetence (NSN-CCs) or competence (SN-CCs) and compared their transcriptomes with the aim of identifying distinct marker transcripts. RESULTS: Global gene expression analysis highlighted that both types of CCs share similar transcriptomes, with the exception of 422 genes, 97.6% of which were down-regulated in NSN-CCs …