Search results for "script"
showing 10 items of 5143 documents
Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia
2020
Objectives Few studies have analyzed factors associated with delirium subtypes. In this study, we investigate factors associated with subtypes of delirium only in patients with dementia to provide insights on the possible prevention and treatments. Design This is a cross-sectional study nested in the "Delirium Day" study, a nationwide Italian point-prevalence study. Setting and participants Older patients admitted to 205 acute and 92 rehabilitation hospital wards. Measures Delirium was evaluated with the 4-AT and the motor subtypes with the Delirium Motor Subtype Scale. Dementia was defined by the presence of a documented diagnosis in the medical records and/or prescription of acetylcholine…
La percepción de amenaza física en la pareja y el bienestar en la juventud
2021
El presente trabajo estudia la percepción de amenaza hacia la seguridad y/o integridad física en las relaciones de pareja durante la juventud en relación con variables del bienestar personal y de pareja en la actualidad. Participaron 316 jóvenes entre 18 y 36 años (M=23.61; DT=3.678), 72.47% se identificaron con el género femenino. Respecto a la orientación sexual, 64.87% fueron heterosexuales y 35.12% de otras orientaciones sexuales. Se evaluó la percepción de amenaza física en la pareja actual y relaciones pasadas (preguntas ad hoc), el bienestar con la pareja actual (SWRS), la satisfacción con la relación (RAS) y el bienestar subjetivo (SWLS y SPANE). La recogida de datos se realizó onli…
Prognostic differences between routine invasive and conservative strategies for the management of high-risk, non-ST segment acute coronary syndromes:…
2007
Abstract Background The optimal revascularization strategy for non-ST elevation acute coronary syndromes (NSTE-ACS) remains controversial, especially in a real world context. The objective of this work was to assess differences at 1 year in all-cause mortality and the composite endpoint of mortality or acute myocardial infarction (MI) between two management strategies for NSTE-ACS: a conservative strategy (CS) versus a routine invasive strategy (RIS). Methods Of 799 consecutive patients admitted to our institution, 369 were treated with CS (from January 2001 to October 2002); 430 patients admitted with the same diagnosis were treated with RIS (from November 2002 to November 2004). A propens…
Accelerated evolution of a minimal 63–amino acid dual transcription factor
2020
Transcription factors control gene expression in all life. This raises the question of what is the smallest protein that can support such activity. In nature, Cro from bacteriophage λ is one of the smallest known repressors (66 amino acids), and activators are typically much larger (e.g., λ cI, 237 amino acids). Previous efforts to engineer a minimal activator from λ Cro resulted in no activity in vivo in cells. In this study, we show that directed evolution results in a new Cro activator-repressor that functions as efficiently as λ cI in vivo. To achieve this, we develop phagemid-assisted continuous evolution (PACEmid). We find that a peptide as small as 63 amino acids functions efficientl…
Case of multifocal glioblastoma with four fusion transcripts of ALK, FGFR2, NTRK2, and NTRK3 genes stresses the need for tumor tissue multisampling f…
2021
Glioblastoma multiforme (GBM) is the most malignant brain tumor with patient mortality rate close to 100%, 5-yr survival rate of ∼5%, and a median survival of 14 mo. GBMs have notorious histomorphologic and molecular heterogeneities thus giving hope for development of future personalized therapies. We describe here a case of a 48-yr-old male patient with three-nodular GBM. To address the question of intratumoral molecular heterogeneity, a comparative analysis of gene expression was performed by using multiple samples collected from different tumor sites with the aid of intraoperative magnetic resonance imaging (MRI). Sixteen GBM biosamples from parietal, temporal, and temporo-polar localiza…
First results of PACTE group's experimental research on translation competence acquisition : the acquisition of declarative knowledge of translation
2014
Autors llistats per ordre alfabètic. Investigadora principal: A. Hurtado Albir This paper presents the first results of empirical-experimental research into the Acquisition of Translation Competence (ATC): the acquisition of declarative knowledge about translation. This study is based on our previous research about Translation Competence (TC). Some of the data collection instruments have, however, been adapted for current use. Details of our research design include type of study, universe and sample population, study variables, data collection instruments, and data analysis processes. The dependent variables were knowledge of translation; translation project; identification and solution of …
Comparative modelling study on enantioresolution of structurally unrelated compounds with amylose-based chiral stationary phases in reversed phase li…
2020
[EN] Polysaccharide-based chiral stationary phases (CSPs) are the most used chiral selectors in HPLC. These CSPs can be used in normal, polar organic and aqueous-organic mobile phases. However, normal and polar organic mobile phases are not adequate for chiral separation of polar compounds, for the analysis of aqueous samples and for MS detection. In these situations, reversed phase conditions, without the usual non-volatile additives incompatible with MS detection, are preferable. Moreover, in most of the reported chiral chromatographic methods, retention is too large for routine work. In this paper, the chiral separation of 53 structurally unrelated compounds is studied using three commer…
Early stress response of human nasal respiratory epithelia after exposure to 1-methoxypropanol-2
2007
To evaluate the impact of 1-methoxypropanol-2 (MEP) for the stimulation of an inflammatory response in human respiratory mucosa, we exposed 22 primary cell cultures of nasal respiratory epithelia of healthy individuals to MEP concentrations at the level of the German MAK-value (100 ppm) and to the 10-fold concentration (1000 ppm). After 4 and 24h we analyzed the transcription of TNF-alpha, IL-1beta, IL-6, IL-8, MCP-1, GMCSF, Cox-1 and Cox-2 by quantitative PCR as well as the release of the respective cytokines by ELISA. At both MEP concentrations we observed a significant increase of TNF-alpha-, IL-1beta-, IL-6- and Cox-2-transcripts after 4h. After 24h cytokine transcription of TNF-alpha, …
La RSE dansles entreprises de la région BFC,des pratiques paradoxales
2022
Cette étude statistique s’intéresse aux pratiques de RSE des entreprises de petite taille de la région Bourgogne Franche Comté (BFC), étant donné que ces dernières sont quasi délaissées par la recherche scientifique au profit des grandes entreprises comme démontré par Oueghlissi (2013). Le choix de la région BFC s’explique par l’accès facilité au terrain et le fait que la RSE est à ce jour peu explorée d’un point de vue académique dans cette région. Elle met en avant plusieurs paradoxes que nous présentons dans cette étude.
The peroxisome proliferator response element (PPRE) present at positions -681/-669 in the rat liver 3-ketoacyl-CoA thiolase B gene functionally inter…
2000
Although previous data showed that the putative thiolase B PPRE located at -681/-669 bind the PPARalpha-RXRalpha heterodimer in vitro (Kliewer et al. (1992) Nature 358, 771-774), there is no evidence about the functional role of this element. By gel mobility-shift assay, we found an interaction of this PPRE with not only PPARalpha but also with HNF-4. By transfection of cells with the putative PPRE-driven luciferase reporter vector and PPARalpha, we found no significant activation of the luciferase gene expression, in contrast to the case with reporter expression driven by the PPRE of the peroxisomal bifunctional enzyme. On the other hand, HNF-4 activated the luciferase gene expression driv…