Search results for "script"

showing 10 items of 5143 documents

Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and Human Umbilical Vein Endothelia…

2010

Matrix metalloproteinases (MMPs) are extracellular zinc-dependent endopeptidases involved in the degradation and remodelling of extracellular matrix in physiological and pathological processes. MMPs also have a role on cell proliferation, migration, differentiation, angiogenesis and apoptosis. Umbilical cord is a special organ subjected to many changes during pre-natal life and whose cells can maintain a certain degree of plasticity also in post-natal period; for example recently they have been used as a source of stem cells. In this work we investigated the expression of MMPs in human umbilical cord and Human Umbilical Vein Endothelial Cells (HUVEC) though immunohistochemistry, RT-PCR and …

Settore BIO/17 - IstologiaUmbilical VeinsHistologyPhysiologyAngiogenesisBiologyMatrix metalloproteinaseUmbilical cordGene Expression Regulation EnzymologicUmbilical veinUmbilical CordExtracellular matrixMatrix Metalloproteinase 10Matrix Metalloproteinase 13ExtracellularmedicineHumansCells CulturedReverse Transcriptase Polymerase Chain ReactionEndothelial CellsCell BiologyGeneral MedicineMatrix metalloproteinases human umbilical cord HUVEC.ImmunohistochemistryMatrix MetalloproteinasesCord liningCell biologyMatrix Metalloproteinase 8medicine.anatomical_structureMatrix Metalloproteinase 9ImmunologyMatrix Metalloproteinase 2Matrix Metalloproteinase 3Stem cellJournal of Molecular Histology
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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A sub-population of mesoangioblasts displays features of resistance and proliferation confirmed by transcriptome analysis.

2014

Settore BIO/18 - Geneticatranscriptome analysimesoangioblastSettore BIO/06 - Anatomia Comparata E Citologia
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Omic-based strategies reveal novel links between primary metabolism and antibiotic production

2008

Settore BIO/19 - Microbiologia GeneraleProteome Transcriptome Actinomycetes
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Le Curve di Apollonio. Innovazione nei processi risolutivi, il caso della parabola.

2012

This study is connected with the research directed on the solving problem of a graphic representation of geometric objects using the informatics language, particularly the graphic software CAD. The solution of these problems requires a reliable command of stereometry and descriptive geometry and it can extend remarkably the level of external geometric competences. The implementation of the means of ICT has brought a higher effectiveness of graphing mapping processes. The modification of informatics means with the goal to simplify applications of descriptive and projective geometry is also of a great didactical importance. In particular, we focus attention on the treatment of the locus "cone…

Settore ICAR/17 - Disegnographic representation ICT descriptive and projective geometry
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Informatics in Descriptive Geometry. Didactic Experience

2009

This study is centred in the environment of the research into solutions of the problems of graphic representation, expressing theoretical considerations which allow the carrying out of geometric-descriptive procedures decoded in informatics language, for implementing CAD commands.

Settore ICAR/17 - Disegnoprogramming language AutoLISP descriptive geometry conic ellipse conjugate diameters
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From the descriptive geometry to the informatics language - Case study

2010

This study is centred in the environment of the research into solutions of the problems of graphic representation, expressing theoretical considerations which allow the carrying out of geometric-descriptive procedures decoded in informatics language, for implementing CAD commands. The solution of these problems requires a reliable command of stereometry and descriptive geometry and it can extend remarkably the level of external geometric competences. The implementation of the means of ICT has brought a higher effectiveness of graphing mapping processes. In the informatics field, the advent of software dedicated to computerized representation has increased the possibilities of investigation …

Settore ICAR/17 - Disegnoprogramming language AutoLISP descriptive geometry representation of conics.
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MIS: Macro Icon System to generate macro algorithms for image analysis in parallel processing

1993

Settore INF/01 - InformaticaGraphical Description Algorithms visual-editor parallel processor language.
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Pictorial information retrieval with uncertain knowledge

1990

In the paper an integrated pictorial database is described. The design of the data management requires many efforts to preserve consistency and integrity. The retrieval operations are designed to support a uniform view of heterogeneous information including uncertain ones; in this last case, non-standard techniques have to be developed. Applications to astronomical images and an outline of the implementation status are given.

Settore INF/01 - InformaticaPictorial Information hierarchical architecture numerical description Pictorial DB
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A Transputer-Based System for Multi-Stroke Character Recognition

1992

A multi-stroke handwritten character recognition system is presented in this paper. A suitable set of Fourier Descriptors is used as features set to describe each stroke. A man-machine interactive algorithm was utilized to accomplish the learning phase and to recognize unknown samples. A PC based prototype was realized at first to test the system. In order to speed up the recognition process, the design and a first prototype of a Transputer-based system have been realized too. Some preliminary experimental results obtained applying these machines to handwritten numerals are reported in the paper.

Settore INF/01 - InformaticaTransputer Recognnition Fourier descriptor handwritten numerals.
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