Search results for "script"
showing 10 items of 5143 documents
High levels of HIF-2α highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche
2007
High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neur…
Regulation of NOS expression in vascular diseases
2020
Nitric oxide synthases (NOS) are the major sources of nitric oxide (NO), a small bioactive molecule involved in the regulation of many cellular processes. One of the most prominent functions of NO is regulation of vasodilatation and thereby control of blood pressure. Most important for vascular tone is NOS3. Endothelial NOS3-generated NO diffuses into the vascular smooth muscle cells, activates the soluble guanylate cyclase resulting in enhanced cGMP concentrations and smooth muscle cell relaxation. However, more and more evidence exist that also NOS1 and NOS2 contribute to vascular function. We summarize the current knowledge about the regulation of NOS expression in the vasculature by tra…
First Retrievals of ASCAT-IB VOD (Vegetation Optical Depth) at Global Scale
2021
Global and long-term vegetation optical depth (VOD) dataset are very useful to monitor the dynamics of the vegetation features, climate and environmental changes. In this study, the radar-based global ASCAT (Advanced SCATterometer) IB (INRAE-BORDEAUX) VOD was retrieved using a model which was recently calibrated over Africa. In order to assess the performance of IB VOD, the Saatchi biomass and three other VOD datasets (ASCAT V16, AMSR2 LPRM V5 and VODCA LPRM V6) derived from C-band observations were used in the comparison. The preliminary results show that IB VOD has a promising ability to predict biomass $(\mathrm{R}=0.74,\ \text{RMSE} =44.82\ \text{Mg}\ \text{ha}^{-1})$ , which is better …
QSPR/QSAR Studies of 2-Furylethylenes Using Bond-Level Quadratic Indices and Comparison with Other Computational Approaches
2017
The recently introduced, non-stochastic and stochastic quadratic indices (Marrero-Ponce <em>et al. J. Comp. Aided Mol. Des.</em> 2006, 20, 685-701) were applied to QSAR/QSPR studies of heteroatomic molecules. These novel bond-based molecular descriptors (MDs) were used for the prediction of the partition coefficient (log P), and the antibacterial activity of 34 derivatives of 2-furylethylenes. Two statistically significant QSPR models using non-stochastic and stochastic bond-based quadratic indices were obtained (R<sup>2</sup> = 0.971, s = 0.137 and R<sup>2</sup> = 0.986, s = 0.096). These models showed good stability to data variation in leave-one-out (L…
La protratta inerzia nell'esigere il credito tra remissione tacita, Verwirkung e divieto di abuso del diritto.
2022
Il saggio muove da un recente sentenza della Corte di cassazione in tema di protratta inerzia nell'esercitare un diritto di credito non ancora prescritto. La Suprema corte ha ritenuto che tale inerzia protratta nel tempo, se suffragata da elementi circostanziali oggettivamente idonei a ingenerare nel debitore un affidamento nella remissione del diritto di credito da parte del creditore per facta concludentia, determina che la improvvisa richiesta di integrale pagamento costituisca abuso del diritto. Sul modello della Verwirkung, elaborata nell’esperienza tedesca, il diritto così esercitato deve ritenersi tacitamente rinunciato. Il saggio critica tanto la soluzione quanto l'impianto dogmatic…
AER Filtering Using GLIDER: VHDL Cellular Automata Description
2008
Cellular Automata (CA) is a bio-inspired processing model for problem solving, initially proposed by Von Neumann. This approach modularizes the processing by dividing the solution into synchronous cells that change their states at the same time in order to get the solution. The communication between them is crucial to achieve the correct solution. On the other hand, the Address-Event-Representation (AER) is a neuromorphic communication protocol for transferring asynchronous events between VLSI chips. These neuro-inspired implementations have been used to design sensor chips (retina, cochleas), processing chips (convolutions, filters) and learning chips, which makes it possible to develop co…
Specific expression of antimicrobial peptide and HSP70 genes in response to heat-shock and several bacterial challenges in mussels
2007
Abstract Defensin, mytilin and myticin are antimicrobial peptides (AMP) involved in mussel innate immunity. Their in vitro antibacterial activity is different according to the targeted bacterial species. To determine if this specificity is correlated to different regulations of gene expressions, adult mussels were challenged in vivo with either Vibrio splendidus LGP32, Vibrio anguillarum , Micrococcus lysodeikticus or by heat shock. RNAs were isolated from circulating hemocytes and AMP mRNAs were quantified by Q-PCR using 28S rRNA as housekeeping gene. In addition, HSP70 gene expression was also quantified as representing non-specific response to stress. In naive mussels, the three AMP mRNA…
PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery.
2019
Subnuclear promyelocytic leukemia (PML) nuclear bodies (NBs) are targeted by many DNA viruses after nuclear delivery. PML protein is essential for formation of PML NBs. Sp100 and Small Ubiquitin-Like Modifier (SUMO) are also permanently residing within PML NBs. Often, large DNA viruses disassemble and reorganize PML NBs to counteract their intrinsic antiviral activity and support establishment of infection. However, human papillomavirus (HPV) requires PML protein to retain incoming viral DNA in the nucleus for subsequent efficient transcription. In contrast, Sp100 was identified as a restriction factor for HPV. These findings suggested that PML NBs are important regulators of early stages o…
Respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of N-acetylcysteine.
2012
Persistent respiratory syncytial virus (RSV) infections have been associated with the exacerbation of chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). This virus infects the respiratory epithelium, leading to chronic inflammation, and induces the release of mucins and the loss of cilia activity, two factors that determine mucus clearance and the increase in sputum volume. These alterations involve reactive oxygen species-dependent mechanisms. The antioxidant N-acetylcysteine (NAC) has proven useful in the management of COPD, reducing symptoms, exacerbations, and accelerated lung function decline. NAC inhibits RSV infection and mucin release in human A54…
A Comparative Study of Nonlinear Machine Learning for the "In Silico" Depiction of Tyrosinase Inhibitory Activity from Molecular Structure.
2011
In the preset report, for the first time, support vector machine (SVM), artificial neural network (ANN), Baye- sian networks (BNs), k-nearest neighbor (k-NN) are applied and compared on two "in-house" datasets to describe the tyrosinase inhibitory activity from the molecular structure. The data set Data I is used for the identification of tyrosi- nase inhibitors (TIs) including 701 active and 728 inactive compounds. Data II consists of active chemicals for potency estimation of TIs. The 2D TOMOCOMD-CARDD atom-based quadratic indices are used as molecular descriptors. The de- rived models show rather encouraging results with the areas under the Receiver Operating Characteristic (AURC) curve …