Search results for "script"
showing 10 items of 5143 documents
Digital control circuitry for the p53 dynamics in cancer cell and apoptosis
2010
Abstract Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in a feedback. This paper proposes an aerospace-based architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is to demonstrate the usefulness of such digital circuitry design to detect and predict the cell species dynamics for shedding light on their inner and mutua…
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma
2018
Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…
COVID-SCORE Spain: public perceptions of key government COVID-19 control measures
2021
Abstract Background Spain was initially one of the countries most affected by the coronavirus disease 2019 (COVID-19) pandemic. In June 2020, the COVID-SCORE-10 study reported that the Spanish public’s perception of their government’s response to the pandemic was low. This study examines these perceptions in greater detail. Methods We employed an ordered logistic regression analysis using COVID-SCORE-10 data to examine the Spanish public’s perception of 10 key aspects of their government’s COVID-19 control measures. These included support for daily needs, mental and general health services, communication, information and coordination, which were examined by gender, age, education level, hav…
Kairós. Un tempo nel mezzo. Percorso multidisciplinare di analisi dell’esperienza di assistenza ai pazienti oncologici terminali
2011
La concezione personalistica cristiana permette una corretta visione antropologi- ca ed etica che fonda le riflessioni delle scienze umane (sociologia, psicologia, pedagogia, scienze della comunicazione) che vogliono analizzare le situazioni in cui versano il paziente oncologico terminale, i suoi familiari e coloro che si occupano dell’attività di assistenza clinico-sanitaria, sociale e volontaria. Se- condo tale concezione, la “persona” è un’unità inscindibile di corpo, psiche e spirito, di sesso maschile e femminile, destinata a una dimensione trascendente e ultraterrena dell’essere. La persona ammalata di cancro, in questa visione, non può essere ridotta a mero agglomerato psicofisico, a…
Celio Sabino e la venalis possessio di C.4.64.1 (Gord., a. 238)
2012
The present work has as its subject a noted constitution by Gordiano from 238 a.d. in which is discussed the theme of guarantee from eviction in terms of trade operations similar to emptio venditio. In terms of ad exemplum ex empto actionis given to the possessio venalis buyer this paper agrees with dominant theory which excludes an actio ex empto identification. Doubts are expressed however on the amenability of the agere p.v., and the conjecture put forward by E. Sciandrello that there was a revision of Celio Sabino's doctrine by the imperial chancellery is also here contested. In reference to hypotheses of possessio non venalis trade, suspicions are expressed regarding the authenticity o…
Persistance et adaptation de Listeria monocytogenes dans le sol : rôle du système de communication Agr
2014
Listeria monocytogenes is a ubiquitous bacterium responsible for listeriosis, a food-borne disease. This pathog•en has been isolated from varions environments of which the telluric environment. The presence of L. monocytogenes in soi! can increase health hazards due to the risk of transfer to vegetables, animais and animal products and water. Considering the role of soil in the circulation of pathogens from fann environment to plant and animal products and eventually to foodstuff, it is critical to identify intrinsic and extrinsic factors that drive the fate of L. monocytogenes in soi!. Genome-wide and transcriptomic analyses found that an important part of the genome of L. monocytogenes (7…
Analyse de la description physique des personages féminins dans "Le Blé en herbe" de Colette
2010
Tutkimuksessani tein analyysin naispuolisten henkilöhahmojen fyysisestä kuvailusta Coletten teoksessa le Blé en herbe. Tavoitteena oli vertailla hahmojen kuvailua ja tutkia, kuinka fyysinen kuvailu heijastaa ja rakentaa hahmon persoonaa. Analyysissä hyödynnetään Yannick Reschin tekemää tutkimusta viiden Coletten romaanin naishenkilöiden kuvailusta. Teoriassa käsitellään henkilöhahmoa kirjallisuudentutkimuksen kannalta, sekä naishahmojen tärkeää roolia Coletten teoksissa. Lisäksi teoria sisältää tarkemman kuvauksen analyysiosion perustana olevasta teoksesta. Analyysissa tutkitaan hahmoja ensin näiden fyysisen olemuksen, terveyden, värien, alastomuuden sekä kasvojen kautta, sekä tämän jälkeen…
The Particularities of Pharmaceutical Care in Improving Public Health Service during the COVID-19 Pandemic
2021
Nowadays, humanity is confronted with one of the most difficult challenges. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was identified for the first time in Hubei, China in December 2019 and produced the COVID-19 pandemic, a devastating disease that led to many complications and deaths. The authorities and the global healthcare system have been alerted regarding the prevention and treatment of this pathology. Even though worldwide quarantine was declared, health care professionals, including pharmacists, have been at the frontline in this war. Since the beginning of the pandemic, the authorities relied on the involvement of the community, hospital, or clinical pharmacists i…
Appropriateness of requests for human serum albumin at the University Hospital of Palermo, Italy: a prospective study
2015
Abstract OBJECTIVE: First, to assess the appropriateness of requests for albumin using current guidelines; second, to evaluate physicians' compliance with this protocol. DESIGN: Descriptive, prospective study. SETTING: 'Paolo Giaccone' University Hospital in Palermo (Italy). PARTICIPANTS: The six departments with the highest orders for albumin. INTERVENTION: An experimental, pharmacist-driven process for daily orders of albumin was activated over a period of 1 month. Pharmacy personnel handed out order forms on six different wards. Physicians were required to select one of a number of intended uses listed on the form. MAIN OUTCOME MEASURES: Data on albumin and serum protein levels; number o…
Sociālais tīkls filozofijas cienītājiem
2022
Šajā dokumentā ir iekļauta Latvijas Universitātes Datorikas fakultātes kursa “Kvalifikācijas darbs” praktiskā darba ietvaros izstrādāta mobila lietotne “ Sociālais tīkls filozofijas cienītājiem” tehniskā dokumentācija, kas sevī ietver programmatūras prasību specifikāciju, datu bāzes un ekrānu projektējums. Sociālais tīkls filozofijas cienītājiem “Philosofy” ir lietotne Android platformai, kas ir paredzēta, kā specializēta iepazīšanās vietne cilvēkiem, kurā balstoties uz lietotāja piedāvātu, kāda domātāja citātu, lietotājs var izvēlēties vai vēlas iesaistīties diskusijā, lietotnē iestrādātajā sarakstes logā, kā arī apskatīt lietotnes satura izstrādātāja ieteiktajos citātos, vai arī ieteikt c…