Search results for "script"
showing 10 items of 5143 documents
La relación entre las palabras clave aportadas por autores de artículos de revista y su indización en las bases de datos ISOC, IME e ICYT
2005
Se analizan las palabras clave proporcionadas por autores en sus artículos científicos y los descriptores asignados a dichos artículos en varias bases de datos para averiguar el papel que juegan esas palabras clave durante el proceso de indización de los mismos. Para ello, se seleccionaron 108 publicaciones periódicas repartidas proporcionalmente entre Ciencias Sociales y Humanidades (36 revistas), Ciencia y Tecnología (36) y Ciencias Médicas y de la Salud (36). De cada una de las 108 publicaciones se escogieron 10 artículos repartidos entre diferentes años, por lo que se trabajó con un total de 1080 que cumplían dos condiciones: poseer palabras clave y estar indizados en las bases de datos…
Barbara Godard, a Translator's Portrait: Analysing the Reception of Québec's Roman au Féminin (1960-1990) in Anglophone Canada
2021
The current dissertation is not only concerned with nourishing the Feminist Translation Studies field with an interdisciplinary perspective into Feminist Translator History. It strives for an understanding of Translation Studies, and Feminist Translation Studies in this particular case, as a cross-disciplinary space where the aims of various disciplines may converge (see Castro 2012). In the particular space of Feminist Translation/Translator History, and in line with Rundle's proposed synergies between Translation Studies and History (2014), the limitations of the so-called "discursive turn" in Feminist History" (Canning 1994) which, despite showing interest in how ideologies operate via h…
Creencias normativas en estrategias preventivas: una espada de doble filo. Efectos de la percepción de normas y normalidad en campañas informativas, …
2009
Las normas descriptivas representan aquellas creencias que relacionan cuántos amigos o compañeros usan drogas y perciben el uso de drogas como algo normal o aceptable. Las intervenciones y estrategias preventivas pueden directa o indirectamente influir sobre las creencias normativas, i.e. la percepción de normas descriptivas. Estas creencias a su vez son unos importantes predictores del consumo de drogas legales e ilegales. El artículo discute la importancia de influir positivamente sobre las normas sociales y su percepción a través de las políticas reguladoras del alcohol y tabaco. Por otra parte se abordan también los problemas éticos que las campañas informativas sobre drogas ilegales pu…
Epidemiological and molecular associations between central nervous system disorders and cancer
2021
The study of comorbidity is becoming a key topic in biomedical research, which is especially relevant in the context of population ageing. Comorbidity has profound implications for individuals, practitioners, and health care systems. As a consequence, increasing efforts are being made by the scientific community to characterize better how disorders relate to each other and to identify the factors producing these associations. Cancer and central nervous system (CNS) disorders are among the top leading causes of death and disease burden worldwide. In recent decades direct and inverse patterns of association between CNS disorders and cancer have been reported. However, observational studies ha…
Ēģiptē viss citādi: ceļojuma novērojumi un iespaidi Ēģiptē 1937. gadā
1937
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by su…
2010
Cholesterol-lowering drugs such as statins influence the proteolytic processing of the amyloid-beta protein precursor (AbetaPP) and are reported to stimulate the activity of alpha-secretase, the major preventive secretase of Alzheimer's disease. Statins can increase the alpha-secretase activity by their cholesterol-lowering properties as well as by impairment of isoprenoids synthesis. In the present study, we elucidate the contribution of these pathways in alpha-secretase activation. We demonstrate that zaragozic acid, a potent inhibitor of squalene synthase which blocks cholesterol synthesis but allows synthesis of isoprenoids, also stimulates alpha-secretase activity. Treatment of human n…
Alpha-secretase as a therapeutic target.
2007
In the non-amyloidogenic pathway the alpha-secretase cleaves the amyloid precursor protein (APP) within the sequence of Abeta-peptides and precludes their formation. In addition, alpha-secretase cleavage releases an N-terminal extracellular domain with neurotrophic and neuroprotective properties. The disintegrin metalloproteinase ADAM10 has been shown to act as alpha-secretase in vivo, to prevent amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. An increase in alpha-secretase activity therefore is an attractive strategy for treatment of AD and may be achieved by modulating selective signalling pathways. Functional characterization of the human ADAM10 prom…
Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristal…
2007
Cannabinoid-1 (CB1) receptor activation affects gastrointestinal propulsion in vivo. It was our aim to further characterize the involved myenteric mechanisms in vivo and in vitro. In CB1(-/-) mice and wild-type littermates we performed in vivo transit experiments by charcoal feeding and in vitro electrophysiological recordings in mouse small intestinal smooth muscle. Ascending neuronal contraction (ANC) following electrical field stimulation was studied in rat ileum in a partitioned organ bath separating the aboral stimulation site from the oral recording site. The knockout animals displayed an accelerated upper gastrointestinal transit compared to control animals. The CB1 receptor antagoni…
Description de la typicite aromatique de vins de bourgogne issus du cepage chardonnay
1993
<p style="text-align: justify;">La typicité aromatique de 23 vins blancs de Bourgogne issus du cépage Chardonnay est évaluée par 32 oenologues au cours de 3 séances. De manière indépendante, une caractérisation de l'odeur et de l'arôme de chaque vin est fournie par chaque sujet sous la forme d'un choix libre de 5 descripteurs au plus.</p><p style="text-align: justify;">Les vins se répartissent selon 3 groupes de typicité croissante sans rapport net avec les appellations. Sept descripteurs-clefs de l'odeur et de l'arôme du Chardonnay de Bourgogne s'imposent: miel, vanille, pain grillé, beurre frais, boisé, floral et noisette. De plus, une liste de 9 autres descripteurs auxi…