Search results for "second-generation"

Chronic fluoxetine treatment in middle-aged rats induces changes in the expression of plasticity-related molecules and in neurogenesis

2012

Abstract Background Antidepressants promote neuronal structural plasticity in young-adult rodents, but little is known of their effects on older animals. The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these structural changes through its anti-adhesive properties. PSA-NCAM is expressed in immature neurons and in a subpopulation of mature interneurons and its expression is modulated by antidepressants in the telencephalon of young-adult rodents. Results We have analyzed the effects of 14 days of fluoxetine treatment on the density of puncta expressing PSA-NCAM and different presynaptic markers in the medial prefrontal cortex, hippocampus and amygdala of mi…

Influence of concomitant medications on the total clearance and the risk for supra-therapeutic plasma concentrations of Citalopram. A population-base…

2014

Introduction: The main objective of this study was to investigate the influence of the use of multiple medications and other risk factors on citalopram plasma concentrations. Methods: A retrospective cohort study with a naturalistic population of 957 patients for whom routine therapeutic drug monitoring (TDM) of citalopram had been requested between 2006 and 2013 was conducted. Results: Concomitant drugs inhibiting at least 2 different CYP subtypes involved in the metabolism of citalopram decreased statistically significantly the total clearance (Clt). Compared to younger patients over 64-year-old patients had on average a 4.5 times higher risk rate of supra-therapeutic plasma concentration…

Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics.

2016

Second-generation antipsychotics (SGAs) are frequently co-prescribed with drug metabolic inducers and inhibitors. SGA pharmacokinetic drug-drug interactions (DDIs) with inducers and inhibitors have not received enough attention in the literature but can be studied in by using therapeutic drug monitoring (TDM).The limited information available on oral SGA pharmacokinetic DDIs is reviewed. A systematic literature search on the available oral SGA TDM studies is completed. By integrating TDM studies with the information on in vitro metabolism studies, case report/series and prospective studies, a table is provided to manage average SGA patients taking inducers or inhibitors by using TDM and/or …

Choices and Enrollments in French Secondary and Higher Education: Repercussions for Second-Generation Immigrants

2013

En ligne sur http://www.jstor.org/discover/10.1086/670729?uid=16804784&uid=3738016&uid=2129&uid=2134&uid=2&uid=70&uid=3&uid=67&uid=16735408&uid=62&uid=5909928&sid=21102655856551; International audience; In France, the proportion of second-generation immigrants enrolling in tertiary education has increased as education has undergone a process of "democratization." This article analyzes their postsecondary choices, access to tertiary programs, dropout, and transition to the labor market, compared to those of students of French origin. Youths of Portuguese origin are more likely to enter vocational higher programs concordant with their preferences and have better chances of completing a tertia…

Bearing fault detection for drivetrains using adaptive filters based wavelet transform

2017

Predicting a localized defect on a rolling bearing during the degradation process before a complete failure is crucial to prevent system failures, unscheduled downtimes and substantial loss of productivity. During this process, impulses associated with the fault are weak, nonstationary or time-frequency varying, and contaminated by noises, which render the problem of extracting these impulses very difficult. This work investigates the effectiveness of common signal processing techniques on predicting incipient faults, e.g. Fast Fourier transform, Short-Time Fourier transform, Wavelet transform. It was found that an adaptive filter is required to enhance and reconstruct the signals during th…

Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

2018

Background For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. Methods The STAR Network "Depot" Study is an observational, longitudinal…

“Evidence of HIV-1 second-generation recombinant strains (SGRs) in Sicily: sequence analysis of gag, pol, and env genes.”

2007

Immigrant Writing: Jhumpa Lahiri and Monica Ali

2009

This paper investigates the importance of second-generation immigrant writing in America and England. The main focus is on a theoretical framework concerning the most typical features in migrant literature and on a literary analysis of Lahiri's collection "Interpreter of Maladies" and Ali's famous novel "Brick Lane".

Effects of acute administration of bupropion on behavior in the elevated plus-maze test by NMRI mice

2004

Bupropion attenuates some symptoms of nicotine abstinence, although its effects on anxiety are unclear. The present study investigates acute effects of bupropion (5, 10, 20 and 40 mg/kg) on anxiety as expressed in the elevated plus-maze test in male NMRI mice. Given the influence of locomotion in this test, effects of bupropion were also evaluated in an actimeter. Spontaneous motor activity remained significantly increased in mice treated with 10, 20 and 40 mg/kg of bupropion during the 60 min recorded. Results from the elevated plus-maze showed that 20 mg/kg increased total arm entries and 40 mg/kg increased total and open arm entries. Although the increase in the number of visits to the o…

Bupropion induced changes in exploratory and anxiety-like behaviour in NMRI male mice depends on the age

2013

The aim of this study was to assess the effects of the antidepressant bupropion on anxiety and novelty-seeking in adolescent mice of different ages and adults. Behavioural differences between early adolescent, late adolescent and adult NMRI mice were measured both in the elevated plus-maze and the hole-board tasks following acute administration of bupropion (5, 10, 15, 20 mg/kg) or saline. In the plus maze test, early and late adolescent mice treated with bupropion (10, 15 mg/kg, respectively) had lower percentages of entries in the open-arms compared to their vehicle controls. Adult mice treated with bupropion did not differ from their vehicle controls. These results suggest that the effec…