Search results for "second-generation"
showing 10 items of 69 documents
Serum concentrations of hydroxybupropion for dose optimization of depressed patients treated with bupropion.
2014
Background Bupropion is a dopamine and norepinephrine reuptake inhibitor approved for the treatment of depression and smoking cessation. According to the recently published reviews, it is a candidate for therapeutic drug monitoring (TDM) to improve therapeutic outcomes and reduce risks of intolerability or intoxication. In practice, however, the use of TDM is limited due to the chemical instability of bupropion. This investigation sought to determine if the major, active, and chemically stable metabolite 4-hydroxybupropion is a suitable measure to guide antidepressant drug therapy with bupropion. Methods 4-Hydroxybupropion serum levels were measured using a newly developed and validated hig…
Bupropion induces social anxiety in adolescent mice: Influence of housing conditions
2016
Abstract Background The antidepressant bupropion has received increasing attention as a pharmacological tool to treat addiction although little is known about its effects on social behaviour in adolescents. The present study aimed to evaluate if environmental housing conditions influence bupropion’s actions on social behaviour of adolescent mice. Methods Mice were either group- or individually housed for 2-weeks and then randomly divided into 2 cohorts: half of the mice remained in the initial housing condition and the other half were changed to isolated conditions for further 2-weeks. The following groups were compared: isolated/isolated (ISO/ISO), isolated/group-housed (ISO/GR), group-hou…
Fluvoxamine but not sertraline inhibits the metabolism of olanzapine: evidence from a therapeutic drug monitoring service.
2001
Therapeutic drug monitoring data of the new atypical neuroleptic drug olanzapine were used to study interactions with the selective serotonin reuptake inhibitors fluvoxamine and sertraline. The distribution of the ratio of concentration/daily dose (C/D; ng/mL per mg/d) of olanzapine was compared in three groups: patients treated with olanzapine (n = 134), patients treated with olanzapine plus fluvoxamine (n = 10) concomitantly, and patients treated with olanzapine plus sertraline (n = 21) concomitantly. No significant difference was seen between the olanzapine and the olanzapine plus sertraline groups. Patients receiving fluvoxamine in addition to olanzapine had C/D ratios that were in the …
Usability of Programming Languages
2016
Programming languages form the interface between programmers (the users) and the computation that they desire the computer to execute. Although studies exist for some aspects of programming language design (such as conditionals), other aspects have received little or no human factors evaluations. Designers thus have little they can rely on if they want to make new languages highly usable, and users cannot easily chose a language based on usability criteria. This SIG will bring together researchers and practitioners interested in increasing the depth and breadth of studies on the usability of programming languages, and ultimately in improving the usability of future languages. nonPeerReviewed
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety,…
2011
Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is expressed in the CNS, where its function is unknown. Here, we show, for the first time, the relevance of MIF expression for adult hippocampal neurogenesis. We identify MIF expression in neurogenic cells (in stem cells, cells undergoing proliferation, and in newly proliferated cells undergoing maturation) in the subgranular zone of the rodent dentate gyrus. A causal function for MIF in cell proliferation was shown using genetic (M…
SECOND-GENERATION MIGRANTS: IDENTIFICATION PROBLEMS
2022
The expression “second-generation” is particularly complex for several reasons. First of all, because of the link with the term “generation,” the use of the adjective “second,” and the meanings attributed to it by those so defined. Moreover, the conceptual category refers to different situations, each with different issues that are difficult to compare. The condition of the second generation or of the set of second-generation migrants appears ambiguous because it oscillates between forms of alienation and forms of belonging, between situations of marginality and situations of activism and protagonism. Therefore, the expression “second-generation” often appears reductive for a number of reas…
Children of migrants in French and Norwegian schools. A comparative analysis of educational attainment of second-generation students and reflections …
2021
International audience
Differential Effects of Fluvoxamine and Other Antidepressants on the Biotransformation of Melatonin
2001
Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19. Both reactions were potently in…
Counter-Narratives Against Prejudice. How Second-Generation Youth Reverse Media Representations
2022
This paper deals with the OLTRE project (ISF - DG Migration and Home Affairs, EU), funded to counter the radicalization of second-generation migrants in Italy and created by a network made up of universities and private companies. This article shows the results of a study regarding the involvement of second-generation youth in the co-production of the social campaign for online communication, representing the outcome of the OLTRE project. The guidelines for the campaign came from our in-depth sociological field research (42 qualitative interviews of 2G youths, 18-30 years, in 7 Italian towns (Palermo, Cagliari, Rome, Bologna, Milan, Padua, Turin) and from theatre laboratories created by sec…
Il movimento Black Lives Matter
2021
The chapter starts with an analysis of unconventional forms of political participation and illustrates the case of the Black Live Matter movement, with a specific focus on the movement in Italy and Sicily and the contribution of second-generation youth.