Search results for "second"
showing 10 items of 3671 documents
Detecting Protein Aggregation on Cells Surface: Concanavalin A Oligomers Formation
2009
A number of neurodegenerative diseases involve protein aggregation and amyloid formation. Recently evidence has emerged indicating small-transient prefibrillar oligomers as the primary pathogenic agents. Noteworthy, strict analogies exist between the behaviour of cells in culture treated with misfolded non-pathogenic proteins and in pathologic conditions, this instance together with the observation that the oligomers and fibrils are characterised by common structural features suggest that common mechanisms for cytotoxicity could exists and have to be perused in common interactions involved in aggregation.We here report an experimental study on ConcanavalinA (ConA) aggregation and its effect…
Robust and sensitive GFP-based cGMP sensor for real time imaging in intact Caenorhabditis elegans
2018
AbstractcGMP is a ubiquitous second messenger that plays a role in sensory signaling and plasticity through its regulation of ion channels and kinases. Previous studies that primarily used genetic and biochemical tools suggest that cGMP is spatiotemporally regulated in multiple sensory modalities, including light, heat, gases, salt and odor. FRET- and GFP-based cGMP sensors were developed to visualize cGMP in primary cell culture and Caenorhabditis elegans to corroborate these findings. While a FRET-based sensor has been used in an intact animal to visualize cGMP, the requirement of a multiple emission system limits its ability to be used on its own as well as with other sensors and fluores…
Effect of self-determined motivation in physical education on objectively measured habitual physical activity
2019
Grounded in the trans-contextual model, the purpose of the present study was to examine the role of self-determined motivation in Physical Education (PE) on self-determined motivation in Physical Activity (PA), PA intention, and accelerometer-measured habitual PA behavior among high-school aged adolescents. A sample of 394 Spanish high-school students (211 males and 183 females; aged 12-16 years) participated in the present study. The outcome measure of PA was established using accelerometry, whereas motivation toward PA and PE as well as PA intention were measured using validated questionnaires. Path analyses supported in part the central propositions of the trans-contextual model. Self-de…
Incivility in online news and Twitter: effects on attitudes toward scientific topics when reading in a second language
2021
Due to the participatory nature of Web 2.0, polite communication on social media and news sites can stand side by side with uncivil comments. Research on online incivility has been conducted with users reading in their mother tongues (L1), while the potential effects of incivility in a second language (L2) have been largely under- explored. This paper analyzes the effects of uncivil comments written in an L2 on attitudes around emerging technologies. Accordingly, study 1 replicates and extends a previous experiment on the effects of incivility to online news on risk perceptions of nanotechnology (Anderson et al., 2014), by adding an ‘L2 condition’ (uncivil comments written in an L2). Then, …
Awareness of language: literacy and second language learning of Spanish in Mexico
2017
This report presents findings from a follow-up exploratory study of the development of writing ability in an attempt to identify key component skills and competencies for elementary school literacy learners, grades 2nd, 4th and 6th. The first evaluation consisted in scoring first draft narrative texts for coherence, the second, an assessment of effective self-correction strategies. These two measures were compared to the results of a third test, of metalinguistic awareness related to children’s ability to distinguish between the two languages that they know, and those of a fourth measure of orthographic knowledge. Participants were bilingual elementary school students from an indigenous com…
El tratamiento de los phrasal verbs en los manuales de inglés lengua extranjera
2020
In this article we will study how phrasal verbs (PhVs) are dealt with in a representative sample of EFL student’s books of Secondary Education and Baccalaureate. From both a quantitative and qualitative point of view, the following aspects will be analysed: (i) whether PhVs are explicitly included into the index of each manual; (ii) whether there are any specific theoretical sections explaining their syntactic and semantic characteristics (and if so, what they consist of); (iii) whether there are any activities and/or exercises designed to practice and internalize these structures and, if any, to which methodological approach they attend; if any differences in the treatment of the PhVs may …
Typical symptom change patterns and their predictors in patients with social anxiety disorder: A latent class analysis
2020
Abstract Objectives The use of trajectories and analysis of change patterns is a promising way toward better differentiation of subgroups in psychotherapy studies. Research on change patterns in social anxiety disorder (SAD) are still rare, although SAD is one of the most common mental disorders. In a secondary analysis of data from the SOPHO-NET-trial (ISRCTN53517394) this study aimed to investigate change patterns and their predictors in a sample of SAD patients. Methods Patients with SAD (N = 357) were randomly assigned to cognitive-behavioral or psychodynamic therapy. The Liebowitz Social Anxiety Scale (LSAS) was assessed at 1st session (pre), 8th session, 15th session and at the end of…
Predicting response to transdiagnostic iCBT for emotional disorders from patient and therapist involvement
2021
Background Transdiagnostic iCBT has been shown to be effective for the treatment of emotional disorders. Less is known about the optimal level of therapist and patient involvement in these interventions. Specific characteristics of Internet-delivered interventions include treatment adherence (e.g., amount of review of the materials) and guidance (e.g., amount of therapist support). Exploring the importance of these elements in treatment outcome may help to maximize the efficiency of Internet-delivered psychological interventions. Aim In this study, we aimed to analyze the relationship between patient and therapist involvement (i.e., platform usage and amount of therapist guidance) in a samp…
Prevalence and determinants of secondary posttraumatic growth following trauma work among medical personnel: a cross sectional study.
2021
ABSTRACT Background: People helping trauma victims as a part of their work may experience positive results, known as Secondary Posttraumatic Growth (SPTG). Aim: The present study aimed to determine the prevalence and determinants of SPTG among medical personnel, considering occupational load, job satisfaction, social support, and cognitive processing of trauma, understood as cognitive coping strategies. Methods: Subjects comprised 419 representatives of the medical profession, including paramedics and nurses. The age of the subjects varied from 19 to 65 (M = 39.60; SD = 11.03). Four standard measurement tools were utilized: the Secondary Posttraumatic Growth Inventory, the Job Satisfaction …
L'accroissement de l'effet de l'origine sociale sur la performance scolaire : par où est-il passé ?
2017
International audience; L'ampleur considérable des inégalités sociales de performances scolaires interroge fortement l'équité de l'école. Nous cherchons, dans ce travail, à mettre en lumière les facteurs de l'accroissement récent de ces inégalités par le biais d'indicateurs disponibles dans les données des enquêtes PISA (2003 et 2012). Nous étudions d'abord l'évolution des différentes composantes de l'indicateur multicritère par lequel l'OCDE mesure le plus souvent le milieu social. Ensuite, nous modélisons, par une analyse en pistes causales, la décomposition de l'effet du statut professionnel des parents sur les performances afin de saisir par quoi il transite. Sont mobilisés des facteurs…