Search results for "second"
showing 10 items of 3671 documents
The Evidence Base for an Ideal Care Pathway for Frail Multimorbid Elderly : Combined Scoping and Systematic Intervention Review
2019
Source at https://doi.org/10.2196/12517. Background: There is a call for bold and innovative action to transform the current care systems to meet the needs of an increasing population of frail multimorbid elderly. International health organizations propose complex transformations toward digitally supported (1) Person-centered, (2) Integrated, and (3) Proactive care (Digi-PIP care). However, uncertainty regarding both the design and effects of such care transformations remain. Previous reviews have found favorable but unstable impacts of each key element, but the maturity and synergies of the combination of elements are unexplored. Objective: This study aimed to describe how the literature o…
Transition to turbulence in serpentine pipes
2017
Abstract The geometry considered in the present work (serpentine pipe) is a sequence of U-bends of alternate curvature. It is characterized by pipe diameter, d = 2a and bend diameter, D = 2c. The repeated curvature inversion forces the secondary flow pattern, typical of all flows in curved ducts, to switch between two mirror-like configurations. This causes (i) pressure drop and heat or mass transfer characteristics much different from those occurring either in a straight pipe or in a constant-curvature pipe, and (ii) an early loss of stability of the base steady-state flow. In the present work, four values of the curvature δ = a/c (0.2, 0.3, 0.4 and 0.5) were considered. For each value of …
Characterization of renewable reductants and charcoal-based pellets for the use in ferroalloy industries
2018
This study investigates the effect of high-temperature pyrolysis and post-treatment processes on spruce and oak charcoal yields and CO2 reactivity in a slow pyrolysis reactor. Post-treatment processes such as co-pyrolysis of biomass and recirculated tar mixture with that to the distillation of the charcoal-tar blend gave similar increase in charcoal yields. From a technological standpoint, co-pyrolysis of charcoal and tar mixture decreased the CO2 reactivity of the charcoal approaching that of fossil-based coke. This emphasize the importance of tar addition and high temperature treatment on charcoal properties. Moreover, the findings of this work show the potential use of the tar organic fr…
Sliding solutions of second-order differential equations with discontinuous right-hand side
2017
We consider second-order ordinary differential equations with discontinuous right-hand side. We analyze the concept of solution of this kind of equations and determine analytical conditions that are satisfied by typical solutions. Moreover, the existence and uniqueness of solutions and sliding solutions are studied. Copyright © 2017 John Wiley & Sons, Ltd.
Collaborative Systems and Environments for Future Working Life: Towards the Integration of Workers, Systems and Manufacturing Environments
2017
While the industrial sector in Europe was previously strongly based on mass production technology, it is now moving towards highly customised products and thus to lot-size-one production. The change in production paradigm is strengthened by the emerging technologies. In small- and medium-sized enterprises (SMEs), this means, for example, the increased use of modern digital manufacturing tools, new additive manufacturing processes and novel engineering intelligence solutions. As a direct result, workers need to develop new skills and competences to effective work. From an educational perspective, it is especially critical that people with few prior successful experiences with fully applying …
Novel concept for stabilising a hydraulic circuit containing counterbalance valve and pressure compensated flow supply
2016
In this paper, a novel concept for stabilising a hydraulic system containing a counterbalance valve and a pressure compensated flow supply is presented. The concept utilizes a secondary circuit where a low-pass filtered value of the load pressure is generated and fed back to the compensator of the flow supply valve. The novel concept has been investigated theoretically and experimentally. A linear model has been developed to verify the improved stability conditions. The novel concept has been implemented on a single boom actuated by a cylinder. The results show that the pressure oscillations in an otherwise unstable system can be suppressed with the novel concept. This happens without any c…
Integrating refugees into higher education – the impact of a new online education program for policies and practices
2018
Gaining access to higher education (HE) is a serious concern for refugees. Although studies on the integration and success of refugees in HE are scarce, the challenges associated with this issue as...
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
2017
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
2016
International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
Unity Makes Strength: A Review on Mutualistic Symbiosis in Representative Insect Clades
2019
Settled on the foundations laid by zoologists and embryologists more than a century ago, the study of symbiosis between prokaryotes and eukaryotes is an expanding field. In this review, we present several models of insect–bacteria symbioses that allow for the detangling of most known features of this distinctive way of living, using a combination of very diverse screening approaches, including molecular, microscopic, and genomic techniques. With the increasing the amount of endosymbiotic bacteria genomes available, it has been possible to develop evolutionary models explaining the changes undergone by these bacteria in their adaptation to the intracellular host environment. The establishmen…