Search results for "secret"

Family and values in three novels by Almudena Grandes : Malena es un nombre de tango, Los aires difíciles and El corazón helado

2017

Family has always inspired great novels which often highlight the relationship between the different generations. The subject of family is indeed constantly reinvested by authors regardless of their nationality or the period they depict. Almudena Grandes belongs to such category of writers and gives a paramount role to the family unit. Although a recurring topic in her literary trajectory, it has never been thoroughly studied by critics who yet analyzed many aspects of her work. Because such topic seemed crucial to us in Grandes’s writing, we focused on the family unit in three of her novels, Malena es un nombre de tango, Los aires difíciles and El corazón helado. In our corpus, family is, …

L'image des écrivaines dans l'univers de Pedro Almodovar. De Patty Diphusa (1984) à Amanda Gris (1995)

2012

Pedro Almodovar, qui a toujours été intéressé par l'écriture, a fréquemment représenté la littérature dans son œuvre, soit par des citations, soit par la création de personnages d'écrivains, qu'il montre à l'écran en train d'écrire des articles, des scénarios ou des romans. Trois personnages d'écrivaines sont particulièrement importants. Patty Diphusa est le nom d'une romancière et essayiste qui apparaît dans la revue la plus célèbre de la Movida madrilène du début des années 80, La Luna de Madrid, où Almodovar signait de ce pseudonyme des articles provocants qui exprimaient l'ivresse de la liberté des mœurs qui régnait dans l'Espagne nouvellement démocratique. Viennent ensuite deux personn…

Secrets de famille, famille de secrets dans Reading in the Dark de Seamus Deane

2006

« La Fortune des Rougon, roman de la connivence » et « La belle nuit, messieurs ! » et « Le théâtre d’ombre »

2015

OS nat; National audience; no abstract

« Cacher son jeu : la poésie frostienne à l'épreuve du sibyllin »

2013

International audience

Confidencialitat en Treball Social

2022

El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València. La confidencialitat en Treball Social és un element clau en les intervencions professionals i és d'obligat compliment segons Codi Deontològic del Consejo General de Trabajo Social Confidentiality in Social Work is a key element in professional interventions and is mandatory according to the Code of Ethics of the General Council of Social Work

Distinctive amino acid residue periodicities in terminal sequences of type III and type I secreted proteins from proteobacteria

2007

AbstractThe Fourier transform (FT) method was applied to specify the distribution of 14 predefined groups of amino acids (64 residues) at both termini of annotated type III and type I secreted proteins from proteobacteria. Type I proteins displayed a higher occurrence of significant periodicities at both C-and N-termini, indicating potent features to discriminate between secretion types, particularly by the use of variables selected from the full periodicity profiles at 19 orders of FT. The Fishers linear discriminant analysis, together with the stepwise selection of variables throughout equal pairs of combinations for all predefined groups of residues, revealed the C-terminal harmonics of …

Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.

2001

SPECIFIC AIMSTo identify the proprotein convertases responsible for maturation of the α-secretase ADAM10, we investigated the influence of PC7 and furin on ADAM10 processing and the resulting effect on amyloid precursor protein cleavage. We also examined the functional role of the ADAM10 prodomain by coexpression of a prodomain-deleted ADAM10 mutant together with its prodomain in trans.PRINCIPAL FINDINGS1. ADAM10 is proteolytically processed by PC7 and furinThe disintegrin metalloproteinase ADAM10 possesses α-secretase activity as well as a potential proprotein convertase recognition sequence (RKKR) after its prodomain. By amino-terminal sequencing of ADAM10 purified from bovine kidney plas…

Potential anticarcinogenic peptides from bovine milk.

2012

Bovine milk possesses a protein system constituted by two major families of proteins: caseins (insoluble) and whey proteins (soluble). Caseins (αS1,αS2,β, andκ) are the predominant phosphoproteins in the milk of ruminants, accounting for about 80% of total protein, while the whey proteins, representing approximately 20% of milk protein fraction, includeβ-lactoglobulin,α-lactalbumin, immunoglobulins, bovine serum albumin, bovine lactoferrin, and lactoperoxidase, together with other minor components. Different bioactivities have been associated with these proteins. In many cases, caseins and whey proteins act as precursors of bioactive peptides that are released, in the body, by enzymatic pro…

Chaperonopathies and chaperonotherapy. Hsp60 as therapeutic target in cancer: potential benefits and risks.

2013

In this minireview we focus on Hsp60 as a target for anticancer therapy. We discuss the new concepts of chaperonopathies and chaperonotherapy and present information on Hsp60 localization in the cell membrane of human tumor cells. We describe novel mechanisms for Hsp60 reaching the extracellular environment that involve membrane-associated stages, as well as data on anti-Hsp60 antibodies found in human sera, both in normal subjects and patients affected by autoimmune diseases. Finally, we discuss possible therapeutic applications of anti-Hsp60 antibodies in cancer treatment, evaluating also side effects on non-tumor cells. In conclusion, the way for investigating Hsp60-targeted anti-tumor t…