Search results for "secretions"
showing 10 items of 286 documents
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation
2015
Complement C1q is the activator of the classical pathway. However, it is now recognized that C1q can exert functions unrelated to complement activation. Here we show that C1q, but not C4, is expressed in the stroma and vascular endothelium of several human malignant tumours. Compared with wild-type (WT) or C3- or C5-deficient mice, C1q-deficient (C1qa−/−) mice bearing a syngeneic B16 melanoma exhibit a slower tumour growth and prolonged survival. This effect is not attributable to differences in the tumour-infiltrating immune cells. Tumours developing in WT mice display early deposition of C1q, higher vascular density and an increase in the number of lung metastases compared with C1qa−/− mi…
Genome-wide association study for milk production traits in an economically important local dairy sheep breed
2021
In this study, we conducted a genome-wide association study (GWAS) for five milk production traits in the Valle del Belice sheep. Repeated measurements for milk yield (MY), fat percentage and yield (F% and FY) and protein percentage and yield (P% and PY) on 481 ewes, were available for the analysis. The animals were genotyped using the Illumina Ovine 50k BeadChip. Weighted deregressed breeding values (DEBVw) were used as phenotypes for GWAS analysis. A total of 23 genome-wide significant SNPs were identified: 3 associated with MY, 9 with FY, and 11 with P%. Several SNPs mapped within known candidate genes or previously reported QTL for milk production traits in livestock species. Additional…
Utilización del Integrated Semen Analysis System (ISAS)® para el análisis morfométrico espermático humano y su significado en las técnicas de reprodu…
2005
Use of the integrated semen analysis system (ISAS ® ) for morphometric analysis and its role in assisted reproduction technologies
Psychometric Comparisons of Benevolent and Corrective Humor across 22 Countries: The Virtue Gap in Humor Goes International
2018
Recently, two instances of virtue-related humor: benevolent and corrective, have been introduced. Benevolent humor treats human weaknesses and wrongdoings benevolently, while corrective humor aims at correcting and bettering them. Twelve marker items for benevolent and corrective humor (BenCor) were developed, and it was demonstrated that they fill the gap between humor as temperament and virtue. The present study investigates responses to the BenCor from 25 samples in 22 countries (overall N = 7, 226). The psychometric properties of the BenCor were found to be sufficient in most of the samples, including internal consistency, unidimensionality, and factorial validity. Importantly, benevole…
Toxic and enzymatic activities of Vibrio vulnificus biotype 2 with respect to host specificity
1996
In this work, the enzymatic activities of selected strains of biotypes 1 and 2 of Vabrio vulnificus were analyzed by using conventional methods and the API ZYM system. The toxic activities of extracellular products (ECPs) were further evaluated by in vitro and in vivo experiments. The ECPs of both biotypes (i) showed high-level hydrolytic activities, (ii) displayed cytotoxicity for fish cell lines, and (iii) were lethal for eels. Exotoxins seem to be proteinaceous since heat treatment of ECP samples destroyed their toxicity. Only biotype 2 strains were virulent for cels, suggesting that host specificity must be related to differences in cell surface properties. Infectivity trials with other…
Effect of pasteurization on the bactericidal capacity of human milk.
2008
The use of human milk in milk banks requires thermal processing to eliminate microbiological hazards. An evaluation is made of the stability of overall human milk bactericidal capacity following 2 modalities of thermal pasteurization: 63°C/30 minutes and 75°C/15 seconds. Ten milk samples (mature milk) were analyzed. In each sample, the effect of both thermal treatments on bactericidal capacity against Escherichia coli was evaluated in relation to the capacity of fresh milk (control). All the samples analyzed possessed bactericidal capacity. Human milk pasteurization induced a significant loss of this capacity that was more pronounced after high-temperature treatment than after low-temperat…
Benevolent and corrective humor, life satisfaction, and broad humor dimensions : extending the nomological network of the BenCor across 25 countries
2020
Indexación: Scopus. Benevolent and corrective humor are two comic styles that have been related to virtue, morality, and character strengths. A previous study also supported the viability of measuring these two styles with the BenCor in 22 countries. The present study extends the previous one by including further countries (a total of 25 countries in 29 samples with N = 7813), by testing the revised BenCor (BenCor-R), and by adding two criterion measures to assess life satisfaction and four broad humor dimensions (social fun/entertaining humor, mockery, humor ineptness, and cognitive/reflective humor). As expected, the BenCor-R showed mostly promising psychometric properties (internal consi…
Benevolent and corrective humor, life satisfaction, and broad humor dimensions: Extending the nomological network of the BenCor across 25 countries
2019
Benevolent and corrective humor are two comic styles that have been related to virtue, morality, and character strengths. A previous study also supported the viability of measuring these two styles with the BenCor in 22 countries. The present study extends the previous one by including further countries (a total of 25 countries in 29 samples with N = 7813), by testing the revised BenCor (BenCor-R), and by adding two criterion measures to assess life satisfaction and four broad humor dimensions (social fun/entertaining humor, mockery, humor ineptness, and cognitive/reflective humor). As expected, the BenCor-R showed mostly promising psychometric properties (internal consistency and factorial…
Failure to Sustain Recovery of Na,K ATPase Function Is a Possible Mechanism for Striatal Neuron Necrosis in Hypoxic-Ischemic Newborn Piglets
1999
Failure to Sustain Recovery of Na,K ATPase Function Is a Possible Mechanism for Striatal Neuron Necrosis in Hypoxic-Ischemic Newborn Piglets
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
2005
Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes of Flt3 mutations occur: internal tandem duplications (ITDs) in the juxtamembrane and point mutations in the tyrosine kinase domain (TKD). We and others have shown that Flt3-ITD induced aberrant signaling including strong activation of signal transducer and activator of transcription 5 (STAT5) and repression of CCAAT/estradiol-binding protein α (c/EBPα) and Pu.1. Here, we compared the signaling properties of Flt3-ITD versus Flt3-TKD in myeloid progenitor cells. We demonstrate that Flt3-TKD mutations induced autonomous growth of 32D ce…