Search results for "selection"

Data from: Chironomus riparius (Diptera) genome sequencing reveals the impact of minisatellite transposable elements on population divergence

2017

Active transposable elements (TEs) may result in divergent genomic insertion and abundance patterns among conspecific populations. Upon secondary contact, such divergent genetic backgrounds can theoretically give rise to classical Dobzhansky-Muller incompatibilities (DMI), thus contributing to the evolution of endogenous genetic barriers and eventually cause population divergence. We investigated differential TE abundance among conspecific populations of the non-biting midge Chironomus riparius and evaluated their potential role in causing endogenous genetic incompatibilities between these populations. We focussed on a Chironomus-specific TE, the minisatellite-like Cla-element, whose activi…

Defining poor prognosis markers of implantation for embryo selection by time-lapse

2012

The multiple directions of evolutionary change.

2008

The theory of Punctuated Equilibria challenges the neo-Darwinian tenet that evolution is a uniform process. Recently, an article by Hunt1 has found that directional change during the evolution of a lineage is relatively small (occurring only in 5% of 250 analyzed traits). Of those traits that were shown to follow a trend, size was more likely to show gradual changes, whereas shape changes were more random. Here, we provide a short view of the nature of evolutionary trends, showing that directional change within lineages and among clades provides valuable evolutionary information about the processes involved in their generation. BioEssays 30:521–525, 2008. © 2008 Wiley Periodicals, Inc.

Darwinism and pharmacogenomics: from 'one treatment fits all' to 'selection of the richest'?

2004

Pharmacogenomics and pharmacogenetics are relatively new fields, and have arisen from recent advances in genetic research. They offer new perspectives on the development of pharmaceuticals, allowing drug design to be targeted specifically to the genotype of selected populations. The discussion of who will be considered for the development of these tailored drugs and who will be excluded, in a situation in which both research resources and public expenditure are limited, is provoking and has led to several, still unanswered ethical questions and concerns about fairness and the potential discrimination of fringe groups. Based on the statistical analyses of population averages, patient groups …

Genetic and Biochemical Characterization of Field-Evolved Resistance to Bacillus thuringiensis Toxin Cry1Ac in the Diamondback Moth, Plutella xyloste…

2004

ABSTRACT The long-term usefulness of Bacillus thuringiensis Cry toxins, either in sprays or in transgenic crops, may be compromised by the evolution of resistance in target insects. Managing the evolution of resistance to B. thuringiensis toxins requires extensive knowledge about the mechanisms, genetics, and ecology of resistance genes. To date, laboratory-selected populations have provided information on the diverse genetics and mechanisms of resistance to B. thuringiensis , highly resistant field populations being rare. However, the selection pressures on field and laboratory populations are very different and may produce resistance genes with distinct characteristics. In order to better…

Cost of host radiation in an RNA virus.

2000

Abstract Although host radiation allows a parasite to expand its ecological niche, traits governing the infection of multiple host types can decrease fitness in the original or alternate host environments. Reasons for this reduction in fitness include slower replication due to added genetic material or modifications, fitness trade-offs across host environments, and weaker selection resulting from simultaneous adaptation to multiple habitats. We examined the consequences of host radiation using vesicular stomatitis virus (VSV) and mammalian host cells in tissue culture. Replicate populations of VSV were allowed to evolve for 100 generations on the original host (BHK cells), on either of two …

The population genetics and evolutionary epidemiology of RNA viruses.

2004

Key Points The authors discuss the main mechanisms of RNA virus evolution — mutation, recombination, natural selection, genetic drift and migration, and how these interact to shape the genetic structure of populations.The quasispecies model of RNA virus evolution is explained and the question of whether this model provides an accurate description of RNA virus evolution is discussed.Experiments that can be carried out to test the basic principles of evolutionary theory are briefly described. The authors review what such experiments have told us about virus evolution and, more widely, what these experiments have revealed in terms of general evolutionary principles.RNA viruses evolve quickly, …

Selezione di Portafoglio e Metaeuristiche

2013

Il problema della selezione del portafoglio (PSP) ha come obiettivo quello di determinare, disponendo di un dato insieme di titoli, il portafoglio che minimizza una misura di rischio per un dato livello di rendimento minimo richiesto. Sebbene nella sua formulazione originaria il PSP può essere risolto utilizzando algoritmi di programmazione lineare o quadratica, l'inclusione di ulteriori vincoli ed obiettivi rende il problema computazionalmente difficile. Nel presente lavoro viene proposto un approccio metaeuristico al PSP in cui vengono considerate diverse misure di distanza tra i portafogli della frontiera efficiente (Mean-Variance) ed il portafoglio ottimo che si ottiene in corrispondenz…

Mutagenesis scanning uncovers evolutionary constraints on tobacco etch Potyvirus membrane-associated 6K2 protein

2019

RNA virus high mutation rate is a double-edged sword. At the one side, most mutations jeopardize proteins functions; at the other side, mutations are needed to fuel adaptation. The relevant question then is the ratio between beneficial and deleterious mutations. To evaluate this ratio, we created a mutant library of the 6K2 gene of tobacco etch potyvirus that contains every possible single-nucleotide substitution. 6K2 protein anchors the virus replication complex to the network of endoplasmic reticulum membranes. The library was inoculated into the natural host Nicotiana tabacum, allowing competition among all these mutants and selection of those that are potentially viable. We identified 1…

KAMA: A Temperature-Driven Model of Mate Choice Using Dynamic Partner Representations

2008

KAMA is a model of mate-choice based on a gradual, stochastic process of building up representations of potential partners through encounters and dating, ultimately leading to marriage. Individuals must attempt to find a suitable mate in a limited amount of time with only partial knowledge of the individuals in the pool of potential candidates. Individuals have multiple-valued character profiles, which describe a number of their characteristics (physical beauty, potential earning power, etc.), as well as preference profiles, that specify their degree of preference for those characteristics in members of the opposite sex. A process of encounters and dating allows individuals to gradually bui…