Search results for "serp"

Oltre l'illusionismo pittorico: i teatrini prospettici nell'architettura siciliana tra Seicento e Settecento

2015

Durante i primi trentanni del XVI secolo l'uso in Sicilia di composizioni scultoree in prospettiva subì un significativo sviluppo grazie all'opera di Antonello Gagini (1478ca-1536) che conferì un vero e proprio effetto tridimensionale alle immagini scolpite nel marmo dando luogo ai cosiddetti "teatrini prospettici". L'inizio artistico di Giacomo Serpotta (1656-1732) diede il via ad una nuova, breve ma significativa fase orientata verso nuovi effetti prospettici. During the first thirty of the 16th century the use in Sicily of perspective compositions in sculptural reliefs underwent significanti development thanks to the work of Antonello Gagini (1478ca-1536) who passed previous models and l…

Growth patterns, sexual dimorphism, and maturation modeled in Pachypleurosauria from Middle Triassic of central Europe (Diapsida: Sauropterygia)

2018

Bone tissue, microanatomy, and growth are studied in humeri of the pachypleurosaurs Dactylosaurus from the early Anisian of Poland and of aff. Neusticosaurus pusillus from the Lettenkeuper (early Ladinian) of southern Germany. Histology and modeled growth curves are compared to already published data of other pachypleurosaurs. Therefore, we herein established growth curves for Anarosaurus from the middle Anisian of Winterswijk (the Netherlands) and for pachypleurosaurs from the Anisian/Ladinian of the Alpine Triassic (i.e., Neusticosaurus spp. and Serpianosaurus). Humeri of Dactylosaurus, Anarosaurus, and aff. N. pusillus, all from the Germanic Basin, usually display an inner ring of (pre-)…

la prospection systématique d’un fond de rivière : l’exemple du Doubs

2020

La présentation des méthodes mises en œuvre et des résultats obtenus à l’occasion d’une opération de prospection subaquatique systématique menée sur la rivière Doubs, en amont de Verdun-sur-le-Doubs (Saône-et-Loire), illustre en grandeur réelle l’intérêt de la démarche adoptée, fondée sur des principes simples, dans la perspective d’un inventaire systématique du patrimoine fluvial immergé. La diversité des vestiges découverts et leur répartition sur la longue durée en soulignent la pertinence mais également, s’il en était encore besoin, la réalité du formidable potentiel archéologique que recèlent les cours d’eau. The presentation of the methods used and results obtained during a systematic…

Transition to turbulence in serpentine pipes

2017

Abstract The geometry considered in the present work (serpentine pipe) is a sequence of U-bends of alternate curvature. It is characterized by pipe diameter, d = 2a and bend diameter, D = 2c. The repeated curvature inversion forces the secondary flow pattern, typical of all flows in curved ducts, to switch between two mirror-like configurations. This causes (i) pressure drop and heat or mass transfer characteristics much different from those occurring either in a straight pipe or in a constant-curvature pipe, and (ii) an early loss of stability of the base steady-state flow. In the present work, four values of the curvature δ = a/c (0.2, 0.3, 0.4 and 0.5) were considered. For each value of …

Dual proteotoxic stress accelerates liver injury via activation of p62‐Nrf2

2021

Protein accumulation is the hallmark of various neuronal, muscular, and other human disorders. It is also often seen in the liver as a major protein-secretory organ. For example, aggregation of mutated alpha1-antitrypsin (AAT), referred to as PiZ, is a characteristic feature of AAT deficiency, whereas retention of hepatitis B surface protein (HBs) is found in chronic hepatitis B (CHB) infection. We investigated the interaction of both proteotoxic stresses in humans and mice. Animals overexpressing both PiZ and HBs (HBs-PiZ mice) had greater liver injury, steatosis, and fibrosis. Later they exhibited higher hepatocellular carcinoma load and a more aggressive tumor subtype. Although PiZ and H…

The analysis of estrogen receptor-α positive breast cancer stem-like cells unveils a high expression of the serpin proteinase inhibitor PI-9: Possibl…

2016

Abstract Breast cancer stem cells seem to play important roles in breast tumor recurrence and endocrine therapy resistance, although the underlying mechanisms have not been well established. Moreover, in some tumor systems the immunosurveillance failure against cancer cells has been related to the presence of the granzyme B inhibitor PI-9. This study explored the status of PI-9 in tumorspheres isolated from estrogen receptor-α positive (ERα+) breast cancer MCF7 cells. Studies were performed in tertiary tumorspheres which possess high levels of stemness markers (Nanog, Oct3/4 and Sox2) and self-renewal ability. The exposure to estrogens (17-β estradiol and genistein) increased the number and…

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

2016

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10−11), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10−8) and 3q28 (rs9815073, LPP, P=3.62 × 10−8), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10−11) in the combined analysis. We find suggestive evidence (P<5 × 10−…

Thermomineral waters of Greece: geochemical characterization

2020

Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells.

2015

Abstract Background: The antihypertensive reserpine is an indole alkaloid from Rauwolfia serpentina and exerts also profound activity against cancer cells in vitro and in vivo. The present investigation was undertaken to investigate possible modes of action to explain its activity toward drug-resistant tumor cells. Material and methods: Sensitive and drug-resistant tumor cell lines overexpressing P-glycoprotein (ABCB1/MDR1), breast cancer resistance protein (ABCG2/BCRP), mutation-activated epidermal growth factor receptor (EGFR), wild-type and p53-knockout cells as well as the NCI panel of cell lines from different tumor origin were analyzed. Reserpine's cytotoxicity was investigated by res…

Treatment with C1 inhibitor concentrate in abdominal pain attacks of patients with hereditary angioedema

2005

BACKGROUND: Abdominal edema attacks in patients with hereditary angioedema are often extremely painful, associated with vomiting and diarrhea, and have a high potential for causing recurrent disability of the patient. STUDY DESIGN AND METHODS: Intraindividual comparison of retrospective data in 75 hereditary angioedema patients comprising 4,834 abdominal attacks treated with C1 inhibitor concentrate versus 17,444 untreated abdominal attacks. RESULTS: The mean duration of abdominal attacks was 92.0 hours (SD, 40.8 hr) when untreated compared to 39.9 hours (SD, 30.0 hr) when treated. Patients reported a mean maximal pain score of 8.6 (SD, 1.7; range, 1-10) for untreated attacks compared to 4.…