Search results for "seulonta"
showing 4 items of 14 documents
Testing for Lynch Syndrome in Endometrial Carcinoma: From Universal to Age-Selective MLH1 Methylation Analysis
2022
Simple Summary International guidelines recommend universal screening of endometrial carcinoma patients for Lynch syndrome, a hereditary cancer predisposition syndrome. Screening is based on mismatch repair protein immunohistochemistry and reflex MLH1 methylation analysis to exclude the likely sporadic cases of MMR deficiency. As sporadic MLH1 protein loss is common in endometrial carcinoma, the ability to target methylation testing would save efforts and costs. We discovered that limiting methylation testing to patients under 65 years would have significantly reduced the testing effort while maintaining a low false negative rate for MLH1-LS detection (0% and 3% in our clinic and registry-b…
Developmental pathways of language development : a longitudinal predictive study from prelinguistic stage to outcome at school entry
2017
This research focused on the pathways of development during the prelinguistic stage and from prelinguistic development to later language ability. The first goal was to follow and describe the development of several prelinguistic communication skills during the first two years of life (Studies I and II). The second goal was to examine the predictive relations between this development and language ability and difficulties, as well as memory, up to school age (Studies I, II, and III). The third goal evaluated the feasibility of parental screening in identifying children at risk for language and communication difficulties (Studies I, II, and III). Prelinguistic skills were followed with a paren…
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
2019
A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…
Kielen kehityksen polut : seurantatutkimus esikielellisen kehityksen vaiheesta koulun alkuun
2018
Lectio Praecursoria nonPeerReviewed