Search results for "severity"

showing 10 items of 1287 documents

Mediterranean Diet Adherence and Congestive Heart Failure: Relationship With Clinical Severity and Ischemic Pathogenesis

2020

Abstract Objectives To our knowledge, no study has addressed the relationship between adherence to a Mediterranean diet style and severity of heart failure. The aim of this retrospective study was to evaluate the relationship between adherence to the Mediterranean diet assessed using the calculation of Mediterranean diet score and congestive heart failure (CHF), its severity, and pathogenesis. Methods We analyzed charts and collected data of all consecutive patients with a diagnosis of CHF at admission to our Internal Medicine Ward from 2008 to 2014. Results We analyzed 209 patients with CHF and 200 controls. Patients with CHF showed a significantly lower mean MeDi score than controls. At r…

Male0301 basic medicinemedicine.medical_specialtySettore MED/09 - Medicina InternaMediterranean dietEndocrinology Diabetes and MetabolismMyocardial Ischemia030209 endocrinology & metabolismDiseaseDiet MediterraneanSeverity of Illness IndexNew york heart associationPathogenesis03 medical and health sciences0302 clinical medicineInternal medicineMediterranean dietmedicineHumansClinical severityCADcardiovascular diseasesAgedRetrospective StudiesAged 80 and overHeart Failure030109 nutrition & dieteticsNutrition and DieteticsReceiver operating characteristicNYHA.business.industryRetrospective cohort studyMiddle Agedmedicine.diseasehumanitiesAdherenceHeart failurePatient ComplianceFemalebusinessCHF
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Is physician assessment of alcohol consumption useful in predicting risk of severe liver disease among people with HIV and HIV/HCV co-infection?

2019

AbstractBackgroundAlcohol consumption is a known risk factor for liver disease in HIV-infected populations. Therefore, knowledge of alcohol consumption behaviour and risk of disease progression associated with hazardous drinking are important in the overall management of HIV disease. We aimed at assessing the usefulness of routine data collected on alcohol consumption in predicting risk of severe liver disease (SLD) among people living with HIV (PLWHIV) with or without hepatitis C infection seen for routine clinical care in Italy.MethodsWe included PLWHIV from two observational cohorts in Italy (ICONA and HepaICONA). Alcohol consumption was assessed by physician interview and categorized ac…

Male030508 substance abuseHIV InfectionsSeverity of Illness IndexCohort StudiesLiver disease0302 clinical medicineRisk FactorsEpidemiologyMedicineHIV InfectionAlcohol consumptionAlcohol consumption HIV-infected HIV/HCV co-infection Severe liver disease030212 general & internal medicineeducation.field_of_studyCoinfectionLiver Diseaselcsh:Public aspects of medicineLiver DiseasesHazard ratioHepatitis CMiddle AgedHepatitis CItalyalcohol consumption; HIV-infected; HIV/HCV co-infection; severe liver diseaseCoinfectionFemale0305 other medical scienceHumanCohort studyResearch ArticleAdultmedicine.medical_specialtyAlcohol DrinkingPopulationSevere liver diseaseHIV/HCV co-infectionNO03 medical and health sciencesEnvironmental healthHumansRisk factorAlcohol consumption; HIV-infected; HIV/HCV co-infection; Severe liver disease; Adult; Alcohol Drinking; Cohort Studies; Female; HIV Infections; Hepatitis C; Humans; Italy; Liver Diseases; Male; Middle Aged; Risk Factors; Severity of Illness Index; CoinfectioneducationHIV-infectedbusiness.industryRisk FactorPublic Health Environmental and Occupational Healthlcsh:RA1-1270medicine.diseaseCohort StudiebusinessBMC Public Health
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A brief online transdiagnostic measure: Psychometric properties of the Overall Anxiety Severity and Impairment Scale (OASIS) among Spanish patients w…

2018

The Overall Anxiety Severity and Impairment Scale (OASIS) is a self-report questionnaire designed to evaluate the severity and functional impairment associated with anxiety. Given its transdiagnostic nature, it can be used indistinctly across anxiety and depressive disorders. In this study, the psychometric properties of the online version of the OASIS were evaluated in a Spanish clinical sample with emotional disorders. Patients (n = 583) with anxiety (n = 250) and depression (n = 333) with a mean age of 37.21 (SD = 12.22), underwent a diagnostic interview and questionnaires assessing anxiety, depression, positive and negative affect, and quality of life. Factorial structure, internal cons…

Male050103 clinical psychologyPsychometricsEmotionsSocial Scienceslcsh:MedicineTest validityAnxietySeverity of Illness Index0302 clinical medicineQuality of lifeMedicine and Health SciencesCutoffPsychologyDiagnosis Computer-AssistedComputer Networkslcsh:ScienceMultidisciplinaryDepression05 social sciencesMiddle AgedAnxiety DisordersConfirmatory factor analysisAnxietyFemalemedicine.symptomPsychologyClinical psychologyResearch ArticleAdultComputer and Information SciencesAdolescentPsychometricsNeuropsychiatric DisordersNeurosesSensitivity and Specificity03 medical and health sciencesYoung AdultRating scaleDiagnostic MedicineMental Health and PsychiatrymedicineHumans0501 psychology and cognitive sciencesAgedPsychiatric Status Rating ScalesDepressive DisorderInternetMood Disorderslcsh:RDiscriminant validityBiology and Life Sciences030227 psychiatryHealth CareSpainQuality of Lifelcsh:QFactor Analysis StatisticalPLoS ONE
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Prospective associations of early-onset Axis I disorders with developing eating disorders

2009

Objective: The purpose of this study is to analyze the developmental relationships of adolescent-onset Axis I mental disorders and eating disorders (EDs).Method: One thousand three hundred eighteen adolescent twins born from 1983 to 1987 completed a professionally administered semistructured psychiatric interview at the age of 14 years and a questionnaire follow-up at the age of 17.5 years.Results: Eating disorders at the age of 17.5 years were significantly predicted by major depressive disorder (odds ratio, 5.9; 95% confidence interval, 2.6-15.3) and generalized anxiety disorder (GAD) (odds ratio, 4.7; 95% confidence interval, 1.8-15.6) at the age of 14 years, when baseline EDs were exclu…

Male050103 clinical psychologySYMPTOMSSeverity of Illness Index0302 clinical medicineSurveys and Questionnaireslcsh:PsychiatryADOLESCENTSProspective StudiesRegistriesFinlandBulimia nervosa05 social sciencesAnxiety Disorders3. Good healthPsychiatry and Mental healthClinical PsychologyEating disordersTWINSGIRLSMajor depressive disorderAnxietyFemalemedicine.symptomPsychologymedicine.medical_specialtyANOREXIA-NERVOSAGeneralized anxiety disorderAdolescentlcsh:RC435-571generalized anxietyAGE 14QUESTIONNAIREArticleFeeding and Eating Disorders03 medical and health sciencesPrevalence of mental disordersBULIMIA-NERVOSAmedicineHumans0501 psychology and cognitive sciencesPsychiatryDepressive Disorder Majorfamilial factorsmedicine.diseaseComorbidity030227 psychiatryRISK-FACTORSadolescencesyömishäiriötAge of onsetmajor depressionCOMORBIDITYComprehensive Psychiatry
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Correction to: The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome

2021

Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting a unique immunopathogenesis.Thirty-six immunocompetent non-COVID-19 and 27 COVID-19 patients with severe pneumonia were prospectively enrolled in a single center, most requiring intensive care. Clinical and biological characteristics (including T cell phenotype and function and plasma concentrations of 30 cytokines) and outcomes were compared.At similar baseline respiratory severity, COVID-19 patients required mechanical ventilation for significantly longer than non-COVID-19 patients …

Male2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Critical CareSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralMEDLINElcsh:MedicineLymphocyte ActivationSeverity of Illness IndexGeneral Biochemistry Genetics and Molecular BiologyImmunophenotypingmedicineHumansAgedAged 80 and overInnate immune systembusiness.industrySARS-CoV-2lcsh:RCorrectionCOVID-19General MedicineMiddle Agedmedicine.diseasePrognosisRespiration ArtificialImmunity InnatePneumoniaImmunologyFemaleFrancebusinessJournal of Translational Medicine
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Clinical Frailty Scale for Risk Stratification in Patients with Sars-Cov-2 Infection

2020

Predictive factors for adverse outcomes in patients with COVID-19 are urgently needed. Data related to the applicability of the Clinical Frailty Scale (CFS) for risk stratification in patients with COVID-19 are currently lacking. We investigated the ability of CFS to predict need for mechanical ventilation and the duration of hospital stays in European patients with COVID-19. In total, 42 patients with confirmed COVID-19 infection admitted to the University Medical Center Mainz between March 3 and April 15 2020 were included into this validation study and data were retrospectively analyzed. CFS was assessed at admission in all patients. Patients were followed for need for mechanical ventil…

Male2474medicine.medical_specialtyTime FactorsMultivariate analysisintensive care unitsmedicine.medical_treatmentPneumonia ViralRisk AssessmentSeverity of Illness IndexGeneral Biochemistry Genetics and Molecular BiologyBetacoronavirusGermanyInternal medicineSeverity of illnessHumansMedicineIn patientPandemicsAgedRetrospective StudiesMechanical ventilationRespiratory Distress SyndromeFrailtySARS-CoV-2business.industryProportional hazards modelBrief ReportAge FactorsCOVID-19Retrospective cohort studyGeneral MedicineLength of StayMiddle AgedRespiration ArtificialPatient DischargeMultivariate AnalysisRisk stratificationFemaleCoronavirus InfectionsRisk assessmentbusinessJournal of Investigative Medicine
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Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

2019

Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early pr…

Male:Medicina Básica [Ciências Médicas]030230 surgeryLogistic regression0302 clinical medicineInjury Severity ScoreInterquartile rangeRisk FactorsAntibioticsAbdomenDiagnosisAcute peritonitis; Early warning score; Emergency surgery; Source control; Abdomen; Adult; Aged; Chi-Square Distribution; Female; Hospital Mortality; Humans; Injury Severity Score; Logistic Models; Male; Middle Aged; Risk Factors; Sepsis; PrognosisHospital MortalityMortality rateAcute peritonitilcsh:Medical emergencies. Critical care. Intensive care. First aidaarly warning scoreAcute peritonitisMiddle AgedEarly warning scorePrognosisacute peritonitis; aarly warning score; emergency surgery; source control; abdomen; adult; aged; chi-square distribution; female; hospital mortality; humans; injury severity score; logistic models; male; middle aged; risk factors; sepsis; prognosis3. Good healthManagementCiências Médicas::Medicina BásicaEmergency MedicineEmergency surgeryInjury Severity ScoreFemaleResearch ArticleHumanAdultmedicine.medical_specialtyLogistic ModelSepsilcsh:SurgeryNO03 medical and health sciencesSource controlInternal medicineSepsismedicineHumansAgedAcute appendicitisScience & TechnologyChi-Square Distributionbusiness.industryAcute peritonitis; Early warning score; Emergency surgery; Source controlRisk FactorAcute appendicitis; Antibiotics; Diagnosis; Management; SurgeryEarly warning scorelcsh:RD1-811lcsh:RC86-88.93126 Surgery anesthesiology intensive care radiologymedicine.diseaseAcute peritonitis ; Early warning score ; Emergency surgery ; Source controlLogistic ModelsObservational studySurgerybusinessChi-squared distributionKidney disease
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Prevention of Hereditary Angioedema Attacks with a Subcutaneous C1 Inhibitor

2017

Prevenció; Atac d'angioedema; Inhibidor C1 Prevención; Ataque de angioedema; Inhibidor C1 Prevention; Angioedema attack; C1 inhibitor BACKGROUND: Hereditary angioedema is a disabling, potentially fatal condition caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use of CSL830, a nanofiltered C1 inhibitor preparation that is suitable for subcutaneous injection, resulted in functional levels of C1 inhibitor activity that would be expected to provide effective prophylaxis of attacks. METHODS: We conducted an international, prospective, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, phase 3 trial to evaluate the …

Male:aminoácidos péptidos y proteínas::péptidos::serpinas::proteínas inactivadoras del complemento C1::proteína inhibidora del complemento C1 [COMPUESTOS QUÍMICOS Y DROGAS]0301 basic medicine:Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores]Enzims proteolítics - InhibidorsSelf AdministrationSeverity of Illness Indexlaw.inventionC1-inhibitorSubcutaneous injection0302 clinical medicineRandomized controlled triallawCross-Over StudiesHereditary Angioedema Types I and IIbiologyEdema - PrevencióGeneral Medicine:Cardiovascular Diseases::Vascular Diseases::Angioedema::Angioedemas Hereditary [DISEASES]AnesthesiaHereditary angioedema:Other subheadings::Other subheadings::/administration & dosage [Other subheadings]Female:Amino Acids Peptides and Proteins::Peptides::Serpins::Complement C1 Inactivator Proteins::Complement C1 Inhibitor Protein [CHEMICALS AND DRUGS]medicine.symptomComplement C1 Inhibitor Protein:enfermedades cardiovasculares::enfermedades vasculares::angioedema::angioedemas hereditarios [ENFERMEDADES]AdultRiskmedicine.medical_specialtyInjections Subcutaneous:Aminoácidos Péptidos y Proteínas::Péptidos::Serpinas::Proteínas Inactivadoras del Complemento 1::Proteína Inhibidora del Complemento C1 [COMPUESTOS QUÍMICOS Y DROGAS]Placebo:Other subheadings::Other subheadings::/prevention & control [Other subheadings]03 medical and health sciencesDouble-Blind MethodInternal medicinemedicineHumans:Therapeutics::Drug Therapy::Drug Administration Routes::Injections::Injections Subcutaneous [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]:Otros calificadores::Otros calificadores::/administración & dosificación [Otros calificadores]Dose-Response Relationship DrugAngioedemabusiness.industry:Terapéutica::Tratamiento Farmacológico::Vías de Administración de Medicamentos::Inyecciones::Inyecciones Subcutáneas [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Injeccions hipodèrmiquesmedicine.diseaseCrossover studyClinical trial:terapéutica::farmacoterapia::vías de administración de medicamentos::inyecciones::inyecciones subcutáneas [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]030104 developmental biology030228 respiratory systembiology.proteinbusinessNew England Journal of Medicine
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Occult hepatitis B virus infection

2000

Many studies have shown that hepatitis B virus infection may also occur in hepatitis B surface antigen-negative patients. This occult infection has been identified both in patients with cryptogenic liver disease and in patients with hepatitis C virus-related chronic hepatitis, and much evidence suggests that it may be a risk factor of hepatocellular carcinoma development. However several aspects of this occult infection remain unclear such as its prevalence and the factor(s) involved in the lack of circulating hepatitis B surface antigen. Moreover, it is uncertain whether the occult hepatitis B virus infection may contribute to chronic liver damage, considering that it is usually associated…

MaleACUTE VIRAL-HEPATITISPOSTTRANSFUSION HEPATITISHBV SURFACE-ANTIGENComorbidityHBV genome HBsAg-negative liver DNA liver diseasemedicine.disease_causeSeverity of Illness IndexSEROLOGICAL MARKERS; TRANSPLANT RECIPIENTS; POSTTRANSFUSION HEPATITIS; HEPATITIS C VIRUS; HEPATOCELLULAR-CARCINOMA; HBV SURFACE-ANTIGEN; ACUTE VIRAL-HEPATITIS; CHRONIC LIVER-DISEASE; POLYMERASE CHAIN-REACTION; occult hepatitis B virus infectionLiver diseaseCHRONIC LIVER-DISEASEHEPATOCELLULAR-CARCINOMAChronic/diagnosis* Hepatitis BDifferential Disease Progression Female Hepatitis B Surface Antigens/analysis* Hepatitis Bhbsag-negative; hbv genome; liver disease; liver dnaIncidenceHepatocellular/diagnosis CarcinomaLiver NeoplasmsGastroenterologyHepatitis CHepatitis BPOLYMERASE CHAIN-REACTIONPrognosisChronic/epidemiology* Humans Incidence Liver Neoplasms/diagnosis Liver Neoplasms/epidemiology* Male Prognosis Risk Assessment Severity of Illness IndexCarcinoma Hepatocellular/diagnosis Carcinoma Hepatocellular/epidemiology* Comorbidity DNA Viral/analysis Diagnosis Differential Disease Progression Female Hepatitis B Surface Antigens/analysis* Hepatitis B Chronic/diagnosis* Hepatitis B Chronic/epidemiology* Humans Incidence Liver Neoplasms/diagnosis Liver Neoplasms/epidemiology* Male Prognosis Risk Assessment Severity of Illness IndexHepatocellular carcinomaDisease Progressionhbv genomeFemaleliver diseaseCarcinoma HepatocellularTRANSPLANT RECIPIENTSRisk AssessmentDiagnosis Differentialoccult hepatitis B virus infectionHepatitis B ChronicViral/analysis DiagnosismedicineHumansRisk factorHepatitis B virusHepatitis B Surface AntigensHepatologybusiness.industryCarcinomaHEPATITIS C VIRUShbsag-negativeliver dnamedicine.diseaseOccultVirologyHepatocellular/epidemiology* Comorbidity DNASEROLOGICAL MARKERSViral replicationImmunologyDNA Viralbusiness
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Association between the polymorphisms of TLR4 and CD14 genes and Alzheimer's disease.

2008

Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia. Inflammation plays a key role in AD and dissecting the genetics of inflammation may provide an answer to the possible treatment. Hence, the better understanding of different molecular and cellular inflammatory mechanisms is crucial for complete knowledge of AD pathophysiology, and for its prevention and drug therapy. Accordingly, in the present study we evaluated whether the pro-inflammatory polymorphisms of lipopolysaccaride-receptors, +896A/G Toll-Like Receptor (TLR4) and -260C/T CD14, are risk factors for AD. The study included both 626 AD …

MaleALZHEIMER'S DISEASEINFLAMMATIONINNATE IMMUNITYTLR4CD14Lipopolysaccharide ReceptorsInflammationSingle-nucleotide polymorphismDiseaseSystemic inflammationPolymorphism Single NucleotideSeverity of Illness IndexDegenerative diseaseINFLAMMATIONAlzheimer DiseaseRisk FactorsDrug DiscoverymedicineDementiaSNPHumansTLR4AgedPharmacologyAged 80 and overbusiness.industryMiddle Agedmedicine.diseaseToll-Like Receptor 4ItalyALZHEIMER'S DISEASEImmunologyINNATE IMMUNITYFemalemedicine.symptomAlzheimer's diseasebusinessCD14
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