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showing 10 items of 6731 documents
Synthesis of 131I-labeled glucose-conjugated inhibitors of O6-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors…
2006
O 6 -Substituted guanine derivatives are powerful agents used for tumor cell sensitization by inhibition of the DNA repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT). To provide targeted accumulation of MGMT inhibitors in tumor tissue as well as tools for in vivo imaging, we synthesized iodinated C 8 -alkyl-linked glucose conjugates of 2-amino-6-(5-iodothenyl)-9H-purine (O 6 -(5-iodothenyl) guanine, ITG) and 2-amino-6-(3-iodobenzyloxy)-9H-purine (O 6 -(5-iodobenzyl) guanine, IBG). These compounds have MGMT inhibitor constants (IC 5 0 values) of 0.8 and 0.45 μM for ITGG and IBGG, respectively, as determined in HeLa S3 cells after 2-h incubation with inhibitor. To substantiate tha…
Prenatal cocaine exposure alters spontaneous and cocaine-induced motor and social behaviors.
2005
The abuse of cocaine in pregnant women could affect emotional behaviors in their descendents. The aim of this work was to evaluate the effects of prenatal cocaine exposure on spontaneous and cocaine-induced motor and social behaviors in mice. Three kinds of prenatal treatment were used: non-treated animals; mice treated daily with physiological saline during the last week of pregnancy; and finally, those treated with cocaine (25 mg/kg) during the same period. Behavioral studies took place on adult males, which were housed in two different conditions: grouped (non-aggressive), or isolated (aggressive). Cocaine-pretreated animals exhibited slight differences in spontaneous motor activity, but…
Mammary pheromone-induced odour learning influences sucking behaviour and milk intake in the newborn rabbit
2016
Newborn rabbits, Oryctolagus cuniculus, locate their mother's nipples through typical orocephalic movements elicited by odour stimuli, in particular by the mammary pheromone (MP). The MP also promotes neonatal odour learning: after single pairing with the MP, an initially neutral odorant becomes able to elicit sucking-related head-searching/oral-grasping movements. However, the behavioural significance of the MP-induced odour learning remains poorly understood. We carried out three experiments to explore its influence on milk intake and compare its consequences with those resulting from nursing-induced conditioning. First, pups conditioned to an odorant by pairing with the MP on postnatal d…
The rise of the middle author: Investigating collaboration and division of labor in biomedical research using partial alphabetical authorship
2017
Contemporary biomedical research is performed by increasingly large teams. Consequently, an increasingly large number of individuals are being listed as authors in the bylines, which complicates the proper attribution of credit and responsibility to individual authors. Typically, more importance is given to the first and last authors, while it is assumed that the others (the middle authors) have made smaller contributions. However, this may not properly reflect the actual division of labor because some authors other than the first and last may have made major contributions. In practice, research teams may differentiate the main contributors from the rest by using partial alphabetical author…
Evolution of Cooperation Patterns in Psoriasis Research: Co-Authorship Network Analysis of Papers in Medline (1942–2013)
2015
BackgroundAlthough researchers have worked in collaboration since the origins of modern science and the publication of the first scientific journals in the eighteenth century, this phenomenon has acquired exceptional importance in the last several decades. Since the mid-twentieth century, new knowledge has been generated from within an ever-growing network of investigators, working cooperatively in research groups across countries and institutions. Cooperation is a crucial determinant of academic success.ObjectiveThe aim of the present paper is to analyze the evolution of scientific collaboration at the micro level, with regard to the scientific production generated on psoriasis research.Me…
Analysis of Production, Impact, and Scientific Collaboration on Difficult Airway Through the Web of Science and Scopus (1981-2013).
2017
Bibliometrics, the statistical analysis of written publications, is an increasingly popular approach to the assessment of scientific activity. Bibliometrics allows researchers to assess the impact of a field, or research area, and has been used to make decisions regarding research funding. Through bibliometric analysis, we hypothesized that a bibliometric analysis of difficult airway research would demonstrate a growth in authors and articles over time.Using the Web of Science (WoS) and Scopus databases, we conducted a search of published manuscripts on the difficult airway from January 1981 to December 2013. After removal of duplicates, we identified 2412 articles. We then analyzed the art…
Phosphorylation of serine residues is fundamental for the calcium-binding ability of Orchestin, a soluble matrix protein from crustacean calcium stor…
2003
International audience; Orchestia cavimana is a terrestrial crustacean, which cyclically stores calcium in diverticula of the midgut, in the form of calcified amorphous concretions. These concretions are associated with a proteinaceous matrix, the main constituent of the soluble matrix is Orchestin, an acidic calcium-binding protein [Testenière et al., Biochem. J. 361 (2002) 327-335]. In the present paper, we clearly demonstrate that Orchestin is phosphorylated on serine and tyrosine residues, but that calcium binding only occurs via the phosphoserine residues. To our knowledge, this is the first example of an invertebrate mineralization for which a post-translational modification is clearl…
INTERRELATIONSHIP BETWEEN SELF-MANAGEMENT OF BIOPSYCHOSOCIAL DEVELOPMENT OF STUDENT’S PERSONALITY AND HEALTH HABITS. THEORETICAL ASPECT
2018
Until now, there has been done little research on the purposeful biopsychosocial development of student personality in Latvia. Also, in pedagogical science there has been little done on the formation of balanced development self-management skills in humans. Each person's biopsychosocial development is in harmony with its health or lifestyle habits. The quality of student life and studies depends on their health which is affected by health habits. Their formation is closely linked to the formation of biopsychosocial development self-management skills in students. The objective of this paper is to analyse the interrelationship between personality biopsychosocial development self-management sk…
A case of possible vocal convergence between frogs and a bird in Himalayan torrents
1984
Several species of frogs of the subgenusRana (Paa) and one species of bird of the genusPhylloscopus, which are calling in or near torrents in the Himalayas, show striking similarities in their vocal signals: 1) The calls are composed of short sequences of notes separated by periods of silence; 2) the notes are pure, short, and have a narrow frequency band; 3) within each sequence, the notes are rhythmically emitted. We suggest that these characteristics may be adaptive, the convergence being caused by the selective pressure of the acoustic constraints of the biotope.
Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene.
2000
In human umbilical vein endothelial cells and in human umbilical vein endothelial cell-derived EA.hy 926 cells, staurosporine (Stsp) and its glycosidic indolocarbazole analogs 7-hydroxystaurosporine (UCN-01) and 4'-N-benzoyl staurosporine (CGP 41251) enhanced nitric-oxide synthase (NOS) III mRNA expression (analyzed by RNase protection assay), protein expression (determined by Western blot), and activity [measured by rat fetal lung fibroblast (RFL-6) reporter cell assay] in a concentration- and time-dependent manner. In contrast, the bisindolylmaleimide analogs GF 109203X, Ro 31-8220 and Go 6983 had no effect on NOS III expression, and Go 6976, a methyl- and cyanoalkyl-substituted nonglycos…