Search results for "shortening"

Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence.

2019

Abstract Telomere shortening rates must be regulated to prevent premature replicative senescence. TERRA R‐loops become stabilized at critically short telomeres to promote their elongation through homology‐directed repair (HDR), thereby counteracting senescence onset. Using a non‐bias proteomic approach to detect telomere binding factors, we identified Npl3, an RNA‐binding protein previously implicated in multiple RNA biogenesis processes. Using chromatin immunoprecipitation and RNA immunoprecipitation, we demonstrate that Npl3 interacts with TERRA and telomeres. Furthermore, we show that Npl3 associates with telomeres in an R‐loop‐dependent manner, as changes in R‐loop levels, for example, …

Age-associated telomere shortening in mouse oocytes

2013

Abstract Background Oocytes may undergo two types of aging. The first is induced by exposure to an aged ovarian microenvironment before being ovulated, known as ‘reproductive or maternal aging’, and the second by either a prolonged stay in the oviduct before fertilization or in vitro aging prior to insemination, known as ‘postovulatory aging’. However, the molecular mechanisms underlying these aging processes remain to be elucidated. As telomere shortening in cultured somatic cells triggers replicative senescence, telomere shortening in oocytes during reproductive and postovulatory aging may predict developmental competence. This study aimed to ascertain the mechanisms underlying altered te…

EMG amplitude of the biceps femoris during jumping compared to landing movements.

2013

Abstract Hamstrings injury is a common occurrence in athletic performance. These injuries tend to occur during a deceleration or landing task suggesting the negative work may be a key component in hamstrings injury. The purpose of this study was to investigate the muscular activity (EMG) of the biceps femoris (BF) in different phases (concentric vs. eccentric) of a Counter Movement Jump (CMJ), Squat Jump (SJ) and the Braking Phase (BP) of a landing task. Twelve female volleyball players performed 5 CMJs, SJs and BPs while surface EMG was recorded using a MuscleLab (BoscoSystemTM, Norway). EMG values were normalized to an maximal voluntary contraction. A repeated measures analysis of varianc…

Short telomeres drive pessimistic judgement bias in zebrafish.

2021

The role of telomerase reverse transcriptase has been widely investigated in the contexts of ageing and age-related diseases. Interestingly, decreased telomerase activities (and accelerated telomere shortening) have also been reported in patients with emotion-related disorders, opening the possibility for subjective appraisal of stressful stimuli playing a key role in stress-driven telomere shortening. In fact, patients showing a pessimistic judgement bias have shorter telomeres. However, in humans the evidence for this is correlational and the causal directionality between pessimism and telomere shortening has not been established experimentally yet. We have developed and validated a judg…

Stretch‐Shortening Cycle Fatigue

2010

Effects of marathon fatigue on running kinematics and economy

2007

International audience; The influence of marathon fatigue on both running kinematics and economy was investigated with 8 subjects. The measurements included a treadmill test at 3 steady submaximal speeds performed before and after the marathon. One complete left leg cycle was videotaped at 100 Hz from the left side at each speed. The analysis included contact time (braking and push-off') and flight time as well as displacements and angular velocities of the left hip and knee. This analysis was complemented by the measurements of the electromyographic (EMG) activity of the gastrocnemius muscle at each running velocity, and energy expenditure (E) of the last 30.s at the 2 slowest speeds. The …

Concentric force enhancement during human movement

2001

In order to understand the possible mechanisms contributing to enhanced concentric performance in stretch-shortening cycle exercises in vivo the present study examined knee extension torque, EMG activity and fascicle length of the vastus lateralis muscle in maximal and submaximal human movements. Maximal concentric knee extensions (120 s-1) were done after pre-stretch and pre-isometric conditions by nine volunteers. During shortening at the knee angle of 115 (180 = extended) the knee extension torque was found to be greater in pre-stretch condition (272 vs. 248 Nm, p < 0.05) although the torque level prior to shortening was smaller than in pre-isometric condition (268 vs. 314 Nm, p< 0.05…

Functional muscle architecture in aging

2014

El problema del acortamiento de curvas asociado a una densidad

2016

A lo largo de la presente Tesis, se estudia el flujo por la curvatura media asociado a una densidad (FCMpsi) de una hipersuperficie, en una variedad riemanniana con densidad. Los principales resultados se obtienen para el caso particular en el que la dimensión de la variedad ambiente es dos y las subvariedades son curvas. A dicho problema, se le llamará problema del acortamiento de curvas asociado a una densidad (PACpsi). En el capítulo uno, se presentan los conceptos básicos para desarrollar y comprender el trabajo de la Tesis. Se da la definición del problema a abordar, se introducen las herramientas necesarias para su estudio y se calculan las fórmulas de variación de las cantidades geom…

Concentric force enhancement during human movement

2001

In order to understand the possible mechanisms contributing to enhanced concentric performance in stretch-shortening cycle exercises in vivo the present study examined knee extension torque, electromyogram (EMG) activity and fascicle length of the vastus lateralis muscle in maximal and submaximal human movements. Maximal concentric knee extensions (120 degrees s(-1)) were done after pre-stretch and pre-isometric conditions by nine volunteers. During shortening at the knee angle of 115 degrees (180 degrees = extended) the knee extension torque was found to be greater in pre-stretch condition (272 vs. 248 N m, P < 0.05) although the torque level prior to shortening was smaller than in pre-iso…