Search results for "sif"
showing 10 items of 30916 documents
Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis
2019
Globally, there is increasing usage and legalization of cannabis. In addition to its reported therapeutic effects, cannabis has several health risks which are not clearly defined. Erectile dysfunction (ED) is the most common male sexual disorder and there are plausible mechanisms linking cannabis use to ED. No attempt has been made to collate the literature on this topic. The aim of this review was to summarize the prevalence and risk of ED in cannabis users compared to controls. A systematic review of major databases from inception to January 1, 2019, without language restriction, was undertaken to identify studies investigating cannabis use and presence of ED. The analysis compared the p…
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
2013
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…
Synthesis, antiproliferative activity, and in silico insights of new 3-benzoylamino-benzo[ b ]thiophene derivatives
2014
A new series of 3-benzoylamino-5-imidazol-5-yl-benzo[b]thiophenes and the parent amino derivatives were synthesized and screened as antitumor agents. All tested compounds showed concentration-dependent antiproliferative activity profile against HeLa cell line, exhibiting GI50 values in the low micromolar range. The most active compounds were tested in cell cycle perturbation experiments. A rapid accumulation of cells in the G2/M phase, with a concomitant reduction of cells in both the S and G0/G1 phases, was observed, suggesting that cell exposure to selected derivatives produces mitotic failure. To rationalize the biological results, the 3-benzoylamino-benzo[b]thiophenes were analyzed thro…
Improving statistical classification methods and ecological status assessment for river macroinvertebrates
2016
Aquatic ecosystems are facing a growing number of human-induced stressors and the need to implement more biomonitoring to assess the ecological status of water bodies is eminent. This dissertation aims at providing tools to reduce the costs and improve the accuracy of freshwater benthic macroinvertebrate biomonitoring. To improve the cost-e ciency, we consider automated classi cation and develop a novel classi er suitable for complex macroinvertebrate image data. To enhance the accuracy of macroinvertebrate biomonitoring, we study the statistical properties of the Percent Model A nity index crucial to current Finnish biomonitoring and the factors a ecting these statistics. Finally, we perfo…
L’approccio dell’etichettamento nello studio della devianza
2020
Il saggio in questione – inserito originariamente in un volume interdisciplinare dedicato alla classificazione dei bambini “con bisogni speciali” – indica come il processo sociale di classificazione sia esso stesso oggetto dell’analisi perché «concepire il problema dei bambini con bisogni speciali in questo modo ci porta a problematizzare il modo in cui è apparsa la stessa categoria», individuando la natura anche politica del processo di definizione del “deviante” che necessita di un approfondimento delle dinamiche storiche, culturali, sociali, politiche, giuridiche che producono le diverse categorie di “bambini con bisogni speciali”. Gli usi della classificazione all’interno delle agenzie …
Calcium mediated polyelectrolyte adsorption on like-charged surfaces.
2011
International audience; Monte Carlo simulations within the primitive model of calcium-mediated adsorption of linear and comb polyelectrolytes onto like-charged surfaces are described, focusing on the effect of calcium and polyion concentrations as well as on the ion pairing between polymers and calcium ions. We use a combination of Monte Carlo simulations and experimental data from titration and calcium binding to quantify the ion pairing. The polymer adsorption is shown to occur as a result of surface overcharging by Ca2+ and ion pairing between charged monomers and Ca2+. In agreement with experimental observations, the simulations predict that the polymer adsorption isotherm goes through …
Predicting Individual Differences from Brain Responses to Music using Functional Network Centrality
2022
Individual differences are known to modulate brain responses to music. Recent neuroscience research suggests that each individual has unique and fundamentally stable functional brain connections irrespective of the task they perform. 77 participants’ functional Magnetic Resonance Imaging (fMRI) responses were measured while continuously listening to music. Using a graph-theory-based approach, we modeled whole-brain functional connectivity. We then calculate voxel-wise eigenvector centrality and subsequently use it to classify gender and musical expertise using binary Support Vector Machine (SVM). We achieved a cross-validated classification accuracy of 97% and 96% for gender and musical exp…
The link of a finitely determined map germ from R 2 to R 2
2010
Let f: (R2, 0) → (R2, 0) be a finitely determined map germ. The link of f is obtained by taking a small enough representative f: U ⊂ R2 → R2 and the intersection of its image with a small enough sphere Sε1 centered at the origin in R2. We will describe the topology of f in terms of the Gauss word associated to its link.
Honey Bee Pollen in Meagre (Argyrosomus regius) Juvenile Diets: Effects on Growth, Diet Digestibility, Intestinal Traits, and Biochemical Markers Rel…
2020
This research aimed to evaluate the effects of the inclusion of honey bee pollen (HBP) in meagre (Argyrosoumus regius) juveniles&rsquo
Les sarcophages mérovingiens en trachyte. Des carrières aux lieux d'enfouissement (Massif central)
2018
A multi-disciplinary team is currently working on trachyte, a volcanic rock from the Chaîne des Puys (French massif central), within a research program supported by the French ministry of Culture. Although it has been known at least since the 19th century that this rock was used for construction and sculpture in antiquity, and in the making of sarcophagi in the middle ages, the systematisation of the research on trachyte, carried out since 2008, has enabled us to make significant advances in the knowledge of its exploitation and dissemination. Geologists have established a detailed identity card of the six volcanoes where massive lava is available, thereby allowing the classification of eac…