Search results for "sig"
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Filipinas en el marco del imperio español en el siglo XIX
2019
[EN] En este artículo se analiza la evolución de Filipinas en las últimas décadas del siglo XVIII y en el transcurso del siglo XIX a través de diferentes epígrafes: la obligada transformación del secular modelo colonial volcado hacia el tráfico del Galeón y las relaciones transpacíficas; la renovada inclinación hacia Asia, el océano Índico y el mar de China; el desarrollo de un sistema económico basado en la exportación de productos filipinos y en la apertura de las islas al exterior; la evolución de la vida política; el camino hacia la modernización; el peso de las órdenes religiosas, la importancia de la población china y la colaboración con élites indígenas como rasgos singulares de Fili…
Roland Barthes. El sentido de la moda
2021
Roland Barthes devoted much of his intellectual interest to the phenomenon of fashion. Long before his famous Système de la Mode, he wrote numerous essays on the subject, mainly of a methodological nature, both to elaborate a coherent historiography of dress and to establish a semiology of dress itself, distinguishing –with Saussure– between costume (langue) and clothing (parole). Indeed, if dress is a heteroclite whole, like language for Saussure, the semiologist’s task is to reconstruct its functioning as a system of signs, not only in the dress described by the magazines (as he does in Système), but also in the dress actually worn. A set of essays, in short, of extreme importance for any…
Il primo concorso per il Palazzo di Giustizia a Roma del 1884. Ricostruzione critica del progetto di Ernesto Basile
2019
1. Breve descrizione dell’oggetto di studio Il concorso del Palazzo di Giustizia di Roma si svolge in quattro fasi svolte tra il 1884 e il 1887. Il progetto per il primo concorso, del 1884, redatto dall’allora giovanissimo Ernesto Basile (Palermo 1857-1932), rivela una grande perizia progettuale che trasforma il complesso programma funzionale in un austero edificio in stile neofiorentino. I disegni originari dell’opera, non realizzata, conservati presso la Dotazione Basile del Dipartimento di Architettura dell’Università di Palermo, sono stati oggetto di studio propedeutico alle fasi di analisi, interpretazione e ricostruzione congetturale del modello digitale. 2. Stato dell’arte e riferime…
Un approccio design-driven alla validazione delle pratiche collaborative per l’economia circolare urbana
2022
L’articolo esplora i metodi e i processi seguiti nella validazione di pratiche collaborative per l’economia circolare urbana. I contenuti presentati sono il risultato dell’attività di ricerca condotta nell’ambito di Reflow, un progetto di ricerca europeo H2020 focalizzato sullo sviluppo di pratiche innovative dedicate a metabolismi urbani circolari. A partire dalla revisione della letteratura e dall’analisi di pratiche relative ai processi collaborativi per l’economia circolare, la pubblicazione identifica una serie di concetti chiave per l’implementazione di progetti di circolarità urbana, evidenziando l’assenza di metodi e strumenti condivisi per la validazione di azioni circolari su larg…
On the Choice of the Extracellular Vesicles for Therapeutic Purposes
2019
Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Thermal anomalies detection in a photovoltaic plant using artificial intelligence: Italy case studies
2021
This paper proposes the application of artificial intelligence techniques for the identification of thermal anomalies that occur in a photovoltaic system due to malfunctions or faults, with the aim to limit the energy production losses by detecting faults at an early stage. The proposed approach is based on a Thermographic Non-Destructive Test conducted with Unmanned Aerial Vehicles equipped with a thermal imaging camera, which allows the detection of abnormal operating conditions without interrupting the normal operation of the PV system rapidly and cost-effectively. The thermographic images and videos are automatically inspected using a Convolutional Neural Network, developed by an open-s…
Laser fluence, repetition rate and pulse duration effects on paint ablation
2006
Abstract The efficiency (mm3/(J pulse)) of laser ablation of paint was investigated with nanosecond pulsed Nd:YAG lasers (λ = 532 nm) as a function of the following laser beam parameters: pulse repetition rate (1–10,000 Hz), laser fluence (0.1–5 J/cm2) and pulse duration (5 ns and 100 ns). In our study, the best ablation efficiency (η ≅ 0.3 mm3/J) was obtained with the highest repetition rate (10 kHz) at the fluence F = 1.5 J/cm2. This ablation efficiency can be associated with heat accumulation at high repetition rate, which leads to the ablation threshold decrease. Despite the low thermal diffusivity and the low optical absorption of the paint (thermal confinement regime), the ablation th…
Formation structure of optimality by thermoeconomics: disassembling thermodynamic and external influences in energy systems’ design
2009
In this paper an original thermoeconomic approach for the optimization of complex energy systems is presented, based on a revitalized concept of “scope”, and therefore indicated as Scope Oriented Thermoeconomics (SOT). In plants including dissipative components, it allows to formulate non-arbitrary allocation criteria as concerns marginal costs; consequently, the optimization process is disassembled to recognize the Formation Structure of Optimality, i.e. the specific influences of thermodynamic and economic parameters in the path toward the optimal design. The method is applied to a very didascalic example, that is the optimization of the condensation temperature in a vapour compression ch…
ACTO II / ACT II Mujeres / Women ¿Es gay la música de Chopin? Aspectos de la recepción de la música de Chopin en el siglo XIX
2021
Considering that it is difficult, if not impossible, for an analysis of Chopin?s music to unmask some aspects of his private life (such as an alleged sexual and affective attraction for individuals of his own sex), we can however argue that, throughout the 19th century, a connection was established between his work and a ?feminine universe.? That connection might have had implications in the way in which the feminized image of its author was constructed. The analysis of certain aesthetic and stylistic traits of Chopin?s music can help understand the causes of that perception.