Search results for "signalling pathway"
showing 3 items of 13 documents
Nitric oxide: a new player in plant signalling and defence responses.
2004
There is increasing evidence that nitric oxide (NO), which was first identified as a unique diffusible molecular messenger in animals, plays important roles in diverse (patho)physiological processes in plants. NO functions include the modulation of hormonal, wounding and defence responses, as well as the regulation of cell death. Enzymes that catalyse NO synthesis and signalling cascades that mediate NO effects have recently been discovered, providing a better understanding of the mechanisms by which NO influences plant responses to various stimuli. Additionally, growing evidence suggests that NO signalling interacts with the salicylic acid and jasmonic acid signalling pathways.
Cancer: Clinical Background and Key Challenges
2011
This chapter is aimed at a wide audience ranging from biologists to medical students and cancer specialists. It provides a comprehensive overview of systems approaches to the pathology and treatment of cancer. In particular, it addresses diagnosis and therapy by interconnecting various aspects of cancer at both the molecular and clinical level, and contrasts the unifying features of malignancies with the daunting diversity of cancer types, stages, and evolutionary processes during treatment. The importance is emphasized of both prevention and innovative treatments in reducing the cancer burden, and of early detection as the link between these two major areas. It sets the stage for analysis …
Systems Biology, Bioinformatics and Medicine Approaches to Cancer Progression Outcomes
2011
Because of the complexity of carcinogenesis and tumour development, it is critical to understand the underlying organizing principles. In this chapter a possible approach is illustrated, starting with a description of breast cancer prognosis as a function of three powerful biological motifs derived from gene expression profiling. A proliferation metagene describing the transition from slow to fast proliferation leads to the most dramatic aggravation of prognosis. A second immune cell metagene represents an opponent of tumour evolution, whereby only fast-proliferating tumours that are not recognized and eliminated by immune cells can progress. In the absence of endocrine treatment, a third m…