Search results for "silmätaudit"
showing 7 items of 7 documents
Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy
2016
PURPOSE. The role of R-Ras in retinal angiogenesis and vascular permeability was evaluated in an oxygen-induced retinopathy (OIR) model using R-Ras knockout (KO) mice and in human diabetic neovascular membranes. METHODS. Mice deficient for R-Ras and their wild-type (WT) littermates were subjected to 75% oxygen from postnatal day 7 (P7) to P12 and then returned to room air. At P17 retinal vascularization was examined from whole mounts, and retinal vascular permeability was studied using Miles assay. Real-time RT-PCR, Western blotting, and immunohistochemistry were used to assess the expression of R-Ras in retina during development or in the OIR model. The degree of pericyte coverage and vasc…
A genome-wide association study of corneal astigmatism: The CREAM Consortium
2018
Contains fulltext : 191261.pdf (Publisher’s version ) (Open Access) Purpose: To identify genes and genetic markers associated with corneal astigmatism. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software. Additionally, estimates of single nucleotide polymorphism (SNP)-based heritability for …
Update and guidance on management of myopia : European Society of Ophthalmology in cooperation with International Myopia Institute
2021
The prevalence of myopia is increasing extensively worldwide. The number of people with myopia in 2020 is predicted to be 2.6 billion globally, which is expected to rise up to 4.9 billion by 2050, unless preventive actions and interventions are taken. The number of individuals with high myopia is also increasing substantially and pathological myopia is predicted to become the most common cause of irreversible vision impairment and blindness worldwide and also in Europe. These prevalence estimates indicate the importance of reducing the burden of myopia by means of myopia control interventions to prevent myopia onset and to slow down myopia progression. Due to the urgency of the situation, t…
Myopia - maailmanlaajuinen epidemia
2021
• Myopian eli likinäköisyyden esiintyvyys on viime vuosikymmeninä lisääntynyt voimakkaasti. • Tähän ovat ilmeisesti vaikuttaneet voimakkaimmin lähikatselun lisääntyminen ja ulkona vietetyn ajan väheneminen. Perintötekijät selittävät myopiasta vain pienen osan. • Ulkoilun lisäämisellä ja pitkäkestoisen lähikatselun välttämisellä on voitu vähentää lasten myopian ilmaantuvuutta. • Useiden silmäsairauksien ja näkövammaisuuden riski lisääntyy myopian voimistuessa. • Atropiinisilmätippojen käytöstä on raportoitu olevan hyötyä likinäköisyyden etenemisen hidastamisessa, mutta pidempiaikaisista hyödyistä ja mahdollisista haitoista tarvitaan seurantatietoa. The prevalence of myopia has increased sig…
Rare variant analyses across multiethnic cohorts identify novel genes for refractive error
2023
Refractive error, measured here as mean spherical equivalent (SER), is a complex eye condition caused by both genetic and environmental factors. Individuals with strong positive or negative values of SER require spectacles or other approaches for vision correction. Common genetic risk factors have been identified by genome-wide association studies (GWAS), but a great part of the refractive error heritability is still missing. Some of this heritability may be explained by rare variants (minor allele frequency [MAF] ≤ 0.01.). We performed multiple gene-based association tests of mean Spherical Equivalent with rare variants in exome array data from the Consortium for Refractive Error and Myopi…
Visual processing in patients with age-related macular degeneration performing a face detection test
2017
Purpose: People with age-related macular degeneration (AMD) have difficulties in familiar face recognition and facial expression discrimination. Our aim was to evaluate the visual processing of faces in AMD patients and whether this would be improved by anti-vascular endothelial growth factor therapy. This was a prospective interventional cohort study. Patients: Twelve patients with monocular wet AMD and 6 control subjects were recruited. Face detection processes were studied using cortical event-related potentials (ERPs). Patients received 3 bevacizumab intravitreal injections to the single affected eye. At baseline and 4–6 weeks after the last injection, clinical presentation and ERPs of …
Hoitoaika lyhenee - koti kutsuu : lyhythoitoinen kirurginen toiminta vanhusten itsensä kokemana
2003
Lyhythoitoinen kirurginen toiminta on ulotettu enimmäkseen nuorille ja työikäisille. Iäkkäistä päiväkirurgisesti leikatuista potilaista suurin osa on kaihipotilaita, joiden palautteet päiväkirurgiasta ovat erinomaisen hyviä.Lyhythoitoinen kirurginen toiminta vaatii toimintaa myös potilaalta. Hänen on osattava lääkitä itseään selvitäkseen kivusta. Hänen on osattava hoitaa kotona itseään ja leikkausaluettaan niin, ettei se infektoidu. Leikkauksen jälkeenkin omasta kunnosta on huolehdittava ja pidettävä yllä sosiaalisia suhteita ja jatkettava harrastuksia. The aim of this study was to examine the experiences of elderly patients who have undergone day surgery of the care process. The aim was to…