Search results for "site"

showing 10 items of 8388 documents

Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems

2019

Biomaterials 192, 612 - 620 (2019). doi:10.1016/j.biomaterials.2018.10.020

570Static ElectricityBiophysicsBioengineering02 engineering and technologyGene deliveryBiomaterials03 medical and health scienceschemistry.chemical_compoundDrug Delivery SystemsX-Ray DiffractionDynamic light scatteringddc:570Scattering Small AngleHumansRNA MessengerParticle Size030304 developmental biology0303 health sciencesMessenger RNAHeparinSmall-angle X-ray scatteringDEAE-DextranBiological activityDendritic CellsTransfection021001 nanoscience & nanotechnologySmall-angle neutron scatteringDextranchemistryMechanics of MaterialsCeramics and CompositesBiophysics0210 nano-technology

researchProduct

Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study

2021

The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines. An interesting feature of this enzyme comes from its regulation mechanism, which involves its binding to an activating dimer before it can be catalytically functional. Once the trimer is formed, the reaction mechanism proceeds through the deprotonation of the lysine followed by the methyl-transfer reaction. Here we present a detailed exploration of the activation mechanism through a QM/MM approach focusing on both steps of the reaction, aiming to provide new…

570StereochemistryLysineTrimerMolecular Dynamics Simulation01 natural sciencesBiochemistryMicrobiologyenzyme catalysisDFTArticleEpigenesis GeneticEnzyme catalysisQM/MM03 medical and health sciencesResidue (chemistry)Deprotonation0103 physical sciencesprotein regulationHumanscancerCàncerMolecular Biology030304 developmental biology0303 health sciencesBinding Sites010304 chemical physicsbiologyChemistryLysineNuclear ProteinsMethylation540QR1-502DNA-Binding ProteinsHistonebiology.proteinTyrosinemethyltransferaseProtein MultimerizationProtonsProteïnesTranscription Factors

researchProduct

Sheet Bending Modelling for AA 5083 Aluminium Alloy

1995

An extensive investigation of the V- and U-die bending processes of AA 5083 aluminium alloy has been performed by means of the finite element method and the experimental tests. The predicted results, in terms of elastic springback and loads, were compared with the experimental ones in similar conditions. At a given punch stroke, the springback ratio K increases with the sheet thickness, and, at a constant sheet thickness, K increases with the punch stroke. The comparison between predicted and experimental K values shows an excellent agreement in all the ranges of punch stroke and sheet thickness investigated. A very good agreement between the predicted bending forces and the experimental on…

6111 aluminium alloyMaterials science5083 aluminium alloy6063 aluminium alloyBendingComposite material5005 aluminium alloyFinite element method

researchProduct

Hydrogenolysis of hydroxymatairesinol on Y derived catalysts: a computational study

2010

Hydrogenolysis of 7-hydroxymatairesinol (HMR) to matairesinol (MAT) occurs on palladium supported acidic catalysts. HMR has three stereochemical centres and naturally exists as a mixture of two diastereoisomers, namely RRR-HMR and SRR-HMR. The latter is significantly more reactive than the former, in the reaction above. In order to elucidate the hydrogenolysis mechanism, simple surface events involving HMR derivatives on aluminated faujasite (H-Y) fragments were simulated by quantum chemical calculations. The metallic function of a Pd/H-Y acidic catalyst was also mimicked by a minimal palladium cluster. Stereochemical evidences pointed already out that water β-elimination on the epimeric ce…

7-HydroxymatairesinolProcess Chemistry and TechnologySupported catalystschemistry.chemical_elementDFT calculationFaujasiteengineering.materialHeterogeneous catalysisMedicinal chemistryHydrogenation/dehydration processeCatalysisCatalysisReaction rateHydroxymatairesinolchemistryHydrogenolysisengineeringOrganic chemistryReactivity (chemistry)Physical and Theoretical ChemistryPalladiumH-Y zeolite

researchProduct

A Multilayered Plate Theory with Transverse Shear and Normal Warping Functions

2016

A multilayered plate theory which takes into account transverse shear and normal stretching is presented. The theory is based on a seven-unknowns kinematic field with five warping functions. Four warping functions are related to the transverse shear behaviour, the fifth is related to the normal stretching. The warping functions are issued from exact three-dimensional solutions. They are related to the variations of transverse shear and normal stresses computed at specific points for a simply supported bending problem. Reddy, Cho-Parmerter and (a modified version of) Beakou-Touratier theories have been retained for comparisons. Extended versions of these theories, able to manage the normal s…

74K20 (Primary) 74Q99 (Secondary)Materials science[SPI] Engineering Sciences [physics][ SPI.MAT ] Engineering Sciences [physics]/MaterialsFOS: Physical sciencesPhysics - Classical PhysicsStatics02 engineering and technologySandwich panelBendingOrthotropic materialVibrationShellsdeformation-theory[SPI]Engineering Sciences [physics]Laminated composite0203 mechanical engineeringComposite plateComposite plates[ SPI ] Engineering Sciences [physics]Image warpingLaminateComputingMilieux_MISCELLANEOUSCivil and Structural EngineeringHigher-order theorybusiness.industryMathematical analysisIsotropyClassical Physics (physics.class-ph)Warping functionBending of platesStructural engineering021001 nanoscience & nanotechnology020303 mechanical engineering & transportsFormulationPlate theoryCeramics and CompositesPlate theorySandwich0210 nano-technologybusinessNormal stretchingFinite-elements

researchProduct

Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia

researchProduct

Ecologia d'ostracodes simbionts (Entocytheridae) de carrancs invasors a Europa

2014

Els entocitèrids són una família d'ostracodes (Crustacea) ectosimbionts (bàsicament comensals) d'altres crustacis, majoritàriament decàpodes d'aigua dolça. Gran part de les espècies d'entocitèrids són originàries d'Amèrica del Nord i Central, i d'Oceania, associades a carrancs de riu americans i australians. No s'han descobert espècies d'entocitèrids en els carrancs de riu natius d'Europa. Les darreres dècades, els carrancs natius europeus s'han vist greument perjudicats per la invasió de carrancs exòtics, degut a fenòmens d'exclusió competitiva i transmissió de simbionts parasitaris. En la present tesi, hem avaluat la presència d'entocitèrids associats a carrancs de riu (natius i exòtics) …

:CIENCIAS DE LA VIDA::Biología animal (Zoología)::Invertebrados [UNESCO]abundanceUNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología)::InvertebradosUNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología)::Parasitología animal:CIENCIAS DE LA VIDA::Biología animal (Zoología)::Parasitología animal [UNESCO]prevalenceUNESCO::CIENCIAS DE LA VIDA::Biología animal (Zoología)::Ecología animalparasite ecologycrustaceaexotic species:CIENCIAS DE LA VIDA::Biología animal (Zoología)::Ecología animal [UNESCO]

researchProduct

Different approaches to marriage downgrading : from an anti-elusive measure to an antidiscriminatory claim

2021

The essay focuses on the different mechanisms of marriage downgrading. Given the principle of ?cross-border continuity? of statuses, limits to this continuity are sometimes admitted and they are placed through downgrading mechanisms. That can occour in the case of same-sex marriages transcription in a Member State which does not allow such marriages, but which does allow samesex registered partnerships. Downgrading mechanism has an anti-elusive function, but it is not without problems in terms of discrimination on the grounds of sexual orientation. A different approach is taken in the case of an opposite-sex couple requesting the downgrading of their marriage, celebrated before the Member S…

:CIENCIAS JURÍDICAS [UNESCO]cross-border coupleregistered partnershippareja transfronterizadiscriminación. 130 147but which does allow samesex registered partnerships. Downgrading mechanism has an anti-elusive functiondowngradingRoberto The essay focuses on the different mechanisms of marriage downgrading. Given the principle of ?cross-border continuity? of statuseslimits to this continuity are sometimes admitted and they are placed through downgrading mechanisms. That can occour in the case of same-sex marriages transcription in a Member State which does not allow such marriagesbut it is not without problems in terms of discrimination on the grounds of sexual orientation. A different approach is taken in the case of an opposite-sex couple requesting the downgrading of their marriagedegradaciónUNESCO::CIENCIAS JURÍDICAScelebrated before the Member State allowed access to registered partnerships for all sex couples. The element of voluntariness seems to be the prerequisite for a proper anti-discrimination rule FamilyFamiliamatrimonio2386-4567 22661 Actualidad jurídica iberoamericana 587897 2021 15 8113553 Different approaches to marriage downgrading from an anti-elusive measure to an antidiscriminatory claim Garettouniones registradasmarriagediscrimination.

researchProduct

Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycl…

2009

Background The prevalence of and risk factors for central nervous system recurrence in patients with acute promyelocytic leukemia are not well established and remain a controversial matter. Design and Methods Between 1996 and 2005, 739 patients with newly diagnosed acute promyelocytic leukemia enrolled in two consecutive trials (PETHEMA LPA96 and LPA99) received induction therapy-with all-trans retinoic acid and idarubicin. Consolidation therapy comprised three courses of anthracycline monochemotherapy (LPA96), with all-trans retinoic acid and reinforced doses of idarubicin in patients with an intermediate or high risk of relapse (LPA99). Central nervous system prophylaxis was not given. Re…

researchProduct

Stress-strain analysis of specimens subjected to tensile loading during moisture uptake

2015

Abstract: A robust and efficient numerical method for the calculation of the internal stress state that develops within structures subjected to mechanical and steady state or transient hygroscopic loading conditions, has been developed. The method encompasses a layer by layer approach whereby the structure is discretised into plies with different material properties corresponding to the different ply moisture content. The proposed method has been validated against finite element solutions, and results from its application on a fully characterised EDT (technical name) polymer binder are presented. The impact of the moisture induced viscoelastic behaviour on the structural response of the cas…

:Engenharia mecânica [Ciências da engenharia e tecnologias]Materials scienceSteady stateMoistureStress–strain analysisMechanical engineering Mechanical engineeringViscoelasticityFinite element methodStress (mechanics)Engenharia mecânica Engenharia mecânica:Mechanical engineering [Engineering and technology]Ultimate tensile strengthComposite materialMaterial properties

researchProduct