Search results for "skeleta"

Verifying the predicted risk of extinction based on ecological characteristics

2021

Red List status of species should reflect species extinction risk. Because data are limited and species response has a time lag, species may be threatened by extinction even if they are not Red‐Listed. The ability to predict species risk of extinction from ecological characteristics holds promises for proactively targeting conservation measures to species at high risk. In 2005, the risk of extinction from ecological characteristics was predicted for 81 species of Finnish butterflies. Now, after 15 years and two additional national Red List assessments, these predictions are verified. Species with a higher risk of extinction according to the original ecological extinction risk rank (EERR) ha…

Endurance Training and Heart Agiogenesis: new insights

2009

Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments

2021

Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting quality of life and overall survival in cancer patients. Pre-clinical studies have shown that blocking activin receptor type 2 (ACVR2) or its ligands and their downstream signaling can preserve muscle mass in rodents bearing experimental cancers, as well as in chemotherapy-treated animals. In tumor-bearing mice, the prevention of skeletal and respiratory muscle wasting was also associated with improved survival. However, the definitive proof tha…

Musculoskeletal disorders and disability among forest industry workers in lower and higher sickness absence groups: a case-control study

2019

Background: Musculoskeletal wellbeing and disorders and explanatory factors were investigated among forest industry employees. Methods: A new positive approach to maintenance of working ability focuses on being present at work. 140 individuals with low sickness absence (≤1.5% in hours during the past 6.5 years) and 140 controls with higher sickness absence (>1.5%), randomly selected from the source population (n = 636) in workplace clusters (n = 5), were studied. Questionnaire data on functioning, musculoskeletal disorders (MSD) and disability, work ability and wellbeing were collected (response rate 65%) during December 2012–January 2013. 183 employees (mean age 48.5; females 32%) particip…

Perimenopausal women show modulation of excitatory and inhibitory neuromuscular mechanisms.

2021

Background Menopausal transition exposes women to an early decline in muscle force and motor function. Changes in muscle quality and function, especially in lower limbs, are crucial, as they expose individuals to increased risk of falls. To elucidate some of the related neuromuscular mechanisms, we investigated cortical inhibition and peripheral muscle twitch force potentiation in women during the early and late stages of perimenopause. Methods Participants were 63 women aged 48–55 years categorized as early (EP, n = 25) or late (LP, n = 38) perimenopausal according to serum follicle-stimulating hormone (FSH) levels and menstrual diaries. EP women had an irregular menstrual cycle and FSH  2…

Veselības aprūpes darbinieku skeleta, muskuļu un saistaudu sistēmas traucējumi saistībā ar psihoemocionāliem riska faktoriem darba vietā

2018

„Veselības aprūpes darbinieku skeleta, muskuļu un saistaudu sistēmas traucējumi saistībā ar psihoemocionāliem riska faktoriem darba vietā”. Darba autore: Ilze Brizga. Darba zinātniskā vadītāja: asoc. profesore, Dr. med. Ženija Roja. Darbs izklāstīts uz 87 lpp., ietver 21 attēlu, 27 tabulas, 12 pielikumus, 48 informatīvos avotus. Pētījums sastāv no 4 daļām. Pirmajā daļā ir apkopota informācija par veselības aprūpes darbinieku ergonomiskiem un psiho-emocionāliem riska faktoriem, skeleta, muskuļu un saistaudu sistēmas traucējumiem un to cēloņiem. Otrajā daļā ir aprakstītas pētījumā pielietotās metodes. Trešajā daļā aprakstīti iegūtie rezultāti. Darbā izstrādāti preventīvie pasākumi skeleta, mu…

Adventiv-Embryonen aus Nicotiana-kallus, der bei Hohen Lichtintensitäten Kultiviert wurde

1965

The formation of embryonic structures in Nicotiana callus tissue has been reported. High intensity of light as a stimulating factor in differentiation is discussed.

The Nasal Epithelium as a Factory for Systemic Protein Delivery

2002

We have previously shown that recombinant Sendai virus (SeV) produces efficient in vivo airway epithelial gene transfer. The ability to produce therapeutic levels of circulating proteins following noninvasive gene transfer would have widespread clinical application. Here, we compared nose, lung, and skeletal muscle for the ability to produce circulating levels of the secreted mouse antiinflammatory cytokine interleukin-10 (IL10) following SeV-mediated gene transfer. High levels of serum IL10 were obtained from each site with a potency order of lung > nose > muscle for a given viral titer. Serum levels from each site were within the likely required range for anti-inflammatory effects. The co…

PTC124-mediated translational readthrough of a nonsense mutation causing Usher syndrome type 1C.

2011

We investigated the therapeutic potential of the premature termination codon (PTC) readthrough-inducing drug PTC124 in treating the retinal phenotype of Usher syndrome, caused by a nonsense mutation in the USH1C gene. Applications in cell culture, organotypic retina cultures, and mice in vivo revealed significant readthrough and the recovery of protein function. In comparison with other readthrough drugs, namely the clinically approved readthrough-inducing aminoglycoside gentamicin, PTC124 exhibits significant better retinal biocompatibility. Its high readthrough efficiency in combination with excellent biocompatibility makes PTC124 a promising therapeutic agent for PTCs in USH1C, as well a…

Osteonecrosis of the jaw as an adverse bisphosphonate event: Three cases of bone metastatic prostate cancer patients treated with zoledronic acid

2007

Bisphosphonates offer a significant improvement in the quality of life for cancer patients; these potent inhibitors of bone resorption have been shown to markedly reduce the morbidity frequently resulting from bone metastases. Despite the success of bisphosphonates as therapeutic agents, however, toxicity in the form of osteonecrosis of the jaw (ONJ) is a rare complication whose incidence rate has climbed in recent years. ONJ is defined as an unexpected development of necrotic bone in the oral cavity, and is commonly associated with administration of the bisphosphonates Pamidronate and Zoledronate. Clinical features include local pain, soft-tissue swelling, and/or loose teeth; ONJ is also o…