Search results for "skitsofrenia"
showing 4 items of 34 documents
Ensi kertaa psykoosiin sairastuneen potilaan sosiaalinen verkosto ja siinä hoitoon tulon jälkeen tapahtuva muutos
2000
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
2019
A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…
Cognition, metacognition and the patient perspective : new ways to evaluate and rehabilitate schizophrenia patients in forensic psychiatric care
2016
This research focused on factors associated with schizophrenia as well as on the feasibility and effectiveness of group metacognitive training (MCT) in schizophrenia patients with a history of violence in a high-security forensic hospital setting. One of the aims was to scrutinize reasoning ability in regards to jumping to conclusions (JTC) cognitive bias and the expression of cognitive insight (insight into one’s own thinking), a metacognitive ability. A second aim was to examine the associations of these factors with each other and with insight into illness and delusions. Moreover, the patients’ health-related quality of life (HRQOL) was explored. A further objective was to study the pote…