Search results for "sleep"

Predicting 19F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase–Inhibitor Complex

2020

Abstract The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been challenging due to the high electron density of the fluorine atom. Nonetheless, reliable 19F chemical‐shift predictions to deduce ligand‐binding modes hold great potential for in silico drug design. Herein, we present a systematic QM/MM study to predict the 19F NMR chemical shifts of a covalently bound fluorinated inhibitor to the essential oxidoreductase tryparedoxin (Tpx) from African trypanosomes, the causative agent of African sleepi…

turbinate surgery by radiofrequency for sleep-disordered breathing

2003

Blir behovet for søvn prioritert på intensiv? : - en kvantitativ undersøkelse av norske intensivavdelingers praksis rundt søvn og sedering

2014

Masteroppgave i spesialsykepleie – Universitetet i Agder 2014 Background: Patients in the intensive care units suffer from sleep disturbances. The lack of sleep may cause physical and psychological disturbances, increased morbidity and prolonged stay. The nurses evaluate patients’ sleep mainly on their own perception. No registration of sleeping and sedation practices has been conducted in intensive care units in Norway. Aim: To get insight into Norwegian intensive care nurses sleeping and sedation practices and what kind of interventions are common to conduct promoting better sleep and to explore if sedation- or sleep assessment tools, or sedation- or sleep protocols were used. Method: A s…

Sleep patterns and psychosocial health of parents of preterm and full-born infants: a prospective, comparative, longitudinal feasibility study

2022

Abstract Background The early birth and hospitalization of a preterm infant in neonatal intensive care unit can produce several emotional and behavioural responses including sleep problems for parents. Few studies have explored sleep and its associations with health and HRQoL over time in this vulnerable parent population. This purpose of this study was to evaluate the feasibility of a prospective, comparative, longitudinal study of the sleep patterns and psychosocial health of preterm and full-born infants’ parents during the first postpartum year. Methods A prospective, comparative, longitudinal feasibility study was conducted. Parents of preterm infants were compared to parents of full-b…

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

2021

AbstractSleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, Scopus, and the Cochrane Library databases from 2010 to 2020. The search terms included “sleep d…

Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea.

2012

Background: Intermittent hypoxia and obesity which are two pathological conditions commonly found in patients with obstructive sleep apnea (OSA), potentially enhance cancer progression. Objective: To investigate whether obesity and/or intermittent hypoxia (IH) mimicking OSA affect tumor growth. Methods: A subcutaneous melanoma was induced in 40 mice [22 obese (40–45 g) and 18 lean (20–25 g)] by injecting 106 B16F10 cells in the flank. Nineteen mice (10 obese/9 lean) were subjected to IH (6 h/day for 17 days). A group of 21 mice (12 obese/9 lean) were kept under normoxia. At day 17, tumors were excised, weighed and processed to quantify necrosis and endothelial expression of vascular endothe…

Miega kvalitātes rādītāju saistība ar vizuālās uztveres spējām

2020

Bakalaura darba pētījuma mērķis bija noskaidrot, vai cilvēkiem ar augstākiem miega kvalitātes rādītājiem ir precīzāka vizuālā uztvere. Pētījumā piedalījās 56 pieaugušie (34 sievietes; 22 vīrieši) vecumā no 18 līdz 63 gadiem (M=36,60, SD=12,90). Pētījumā tika izmantotas šādas metodes: Pitsburgas miega kvalitātes indeksa aptauja un Vizuālās uztveres tests. Pētījumā iegūtie rezultāti norāda, ka konkrētajā izlasē pastāv statistiski nozīmīgas korelācijas. Uzrādījās statistiski nozīmīga negatīva korelācija starp vizuālās uztveres testa rezultātiem un miega traucējumu apakšskalu; starp vizuālās uztveres testa rezultātiem un iemigšanas laika apakšskalu; starp vizuālās uztveres testa rezultātiem un …

Fatigue, sleep, and nocturnal complaints in patients with amyotrophic lateral sclerosis

2012

Background and purpose: Fatigue is a common symptom in amyotrophic lateral sclerosis (ALS). Although sleep disturbances are a candidate factor that may interfere with fatigue in patients with ALS, the role of sleep-related abnormalities in determining fatigue in ALS is unknown. Objective: To evaluate the frequency and determinants of fatigue in a group of 91 consecutive patients with ALS, with special attention to the relationship between fatigue and sleep problems. Methods: Measures included the Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), ALS Functional Rating ScaleRevised (ALSFRS-R), and Beck Depression Inventory (BDI). Results: The…

ELM Regularized Method for Classification Problems

2016

Extreme Learning Machine (ELM) is a recently proposed algorithm, efficient and fast for learning the parameters of single layer neural structures. One of the main problems of this algorithm is to choose the optimal architecture for a given problem solution. To solve this limitation several solutions have been proposed in the literature, including the regularization of the structure. However, to the best of our knowledge, there are no works where such adjustment is applied to classification problems in the presence of a non-linearity in the output; all published works tackle modelling or regression problems. Our proposal has been applied to a series of standard databases for the evaluation o…

Lifestyle changes and mental health during the COVID-19 pandemic: A repeated, cross-sectional web survey

2021

VBM acknowledges the national grant PI16/01770 from the Instituto de Salud Carlos III, ISCIII (The PROBILIFE study). EV thanks the support of the Spanish Ministry of Science and Innovation (PI15/00283, PI18/00805) integrated into the Plan Nacional de I+D+I and co-financed by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER); the Instituto de Salud Carlos III; the CIBER of Mental Health (CIBERSAM) (...)