Search results for "slow-wave sleep"
showing 10 items of 33 documents
Network Physiology of Cortico–Muscular Interactions
2020
Skeletal muscle activity is continuously modulated across physiologic states to provide coordination, flexibility and responsiveness to body tasks and external inputs. Despite the central role the muscular system plays in facilitating vital body functions, the network of brain-muscle interactions required to control hundreds of muscles and synchronize their activation in relation to distinct physiologic states has not been investigated. Recent approaches have focused on general associations between individual brain rhythms and muscle activation during movement tasks. However, the specific forms of coupling, the functional network of cortico-muscular coordination, and how network structure a…
Granger causality analysis of sleep brain-heart interactions
2014
We studied the networks of Granger causality (GC) between the time series of cardiac vagal autonomic activity and brain wave activities, measured respectively as the normalized high frequency (HF) component of heart rate variability and EEG power in the δ, θ, α, Ï, β bands, computed in 10 healthy subjects during sleep. GC analysis was performed by vector autoregressive modeling, and significance of each link in the network was assessed using F-statistics. The whole-night analysis revealed the existence of a fully connected network of brain-heart and brain-brain interactions, with the à EEG power acting as a hub which conveys the largest number of GC links between the heart and brain n…
Essential thalamic contribution to slow waves of natural sleep
2013
Slow waves represent one of the prominent EEG signatures of non-rapid eye movement (non-REM) sleep and are thought to play an important role in the cellular and network plasticity that occurs during this behavioral state. These slow waves of natural sleep are currently considered to be exclusively generated by intrinsic and synaptic mechanisms within neocortical territories, although a role for the thalamus in this key physiological rhythm has been suggested but never demonstrated. Combining neuronal ensemble recordings, microdialysis, and optogenetics, here we show that the block of the thalamic output to the neocortex markedly (up to 50%) decreases the frequency of slow waves recorded dur…
Comment on “Sleep disturbances and later cognitive status: a multi-centre study”
2018
To investigate the associations between sleep disturbances in mid-life and late-life and late-life cognitive status.In four population-based studies (three Swedish studies: H70 study, Kungsholmen Project (KP) and The Swedish Panel Study of Living Conditions of the Oldest Old (SWEOLD); and one Finnish study: Cardiovascular Risk Factors, Aging and Dementia (CAIDE)), participants provided self-reports on insomnia, nightmares and general sleep problems. Late-life cognitive status was measured by the Mini Mental State Exam (MMSE). The associations between late-life sleep disturbances and cognition 3-11 years later were investigated across all studies (n = 3210). Mean baseline ages were 70 (CAIDE…
TRIB1 constitutes a molecular link between regulation of sleep and lipid metabolism in humans.
2012
Epidemiological studies show association between sleep duration and lipid metabolism. In addition, inactivation of circadian genes induces insulin resistance and hyperlipidemia. We hypothesized that sleep length and lipid metabolism are partially controlled by the same genes. We studied the association of total sleep time (TST) with 60 genetic variants that had previously been associated with lipids. The analyses were performed in a Finnish population-based sample (N = 6334) and replicated in 2189 twins. Finally, RNA expression from mononuclear leucocytes was measured in 10 healthy volunteers before and after sleep restriction. The genetic analysis identified two variants near TRIB1 gene th…
REM sleep behavior disorder and periodic leg movements during sleep in ALS
2017
Objective To assess sleep characteristics and the occurrence of abnormal muscle activity during sleep, such as REM sleep without atonia (RSWA), REM sleep behavior disorder (RBD), and periodic leg movements during sleep (PLMS), in patients with amyotrophic lateral sclerosis (ALS). Methods A total of 41 patients with ALS and 26 healthy subjects were submitted to clinical interview and overnight video-polysomnography. Results A total of 22 patients with ALS (53.6%) reported poor sleep quality. Polysomnographic studies showed that patients with ALS had reduced total sleep time, increased wakefulness after sleep onset, shortened REM and slow-wave sleep, and decreased sleep efficiency, compared t…
Brief Communication HUMAN SCALP RECORDED SIGMA ACTIVITY IS MODULATED BY SLOW EEG OSCILLATIONS DURING DEEP SLEEP
2002
The EEG during deep sleep exhibits a distinct cortically generated slow oscillation of around and below 1 Hz which can be distinguished from other delta (0.5-3.5 Hz) activity. Intracranial studies showed that this slow oscillation triggers and groups cortical network firing. In the present study, we examined whether the phases of the slow oscillation during sleep stage 4 are correlated with the magnitude of sigma (12-16 Hz) and gamma (> 20 Hz) scalp activity. For this purpose, 10-min segments of uninterrupted stage 4 sleep EEG from 9 subjects were analyzed by applying wavelet techniques. We found that scalp recorded sigma, but not gamma, activity is modulated by the phases of the slow oscil…
Differential electrodermal and phasic heart rate responses to personally relevant information: Comparing sleep and wakefulness
2010
This study examined autonomic physiological responses to personally relevant information presented during sleep and wakefulness. Heart rate and electrodermal reactions to subjects’ own first name and other first names were measured during sleep stage 2, rapid eye movement (REM) sleep, and wakefulness. Across all conditions, larger skin conductance responses were elicited by subjects’ own first name. During REM sleep, personally relevant information led to larger heart rate acceleration, whereas an enhanced deceleration was examined during wakefulness. These findings suggest that auditory information is processed on a semantic level even during sleep. However, personally relevant information…
No Effects of Pulsed High-Frequency Electromagnetic Fields on Heart Rate Variability during Human Sleep<sup>1</sup>
1998
The influence of pulsed high-frequency electromagnetic fields emitted by digital mobile radio telephones on heart rate during sleep in healthy humans was investigated. Beside mean RR interval and total variability of RR intervals based on calculation of the standard deviation, heart rate variability was assessed in the frequency domain by spectral power analysis providing information about the balance between the two branches of the autonomic nervous system. For most parameters, significant differences between different sleep stages were found. In particular, slow-wave sleep was characterized by a low ratio of low- and high-frequency components, indicating a predominance of the parasympathe…
REM sleep behavior disorder and periodic leg movements in sleep in patients with amyotrophic lateral sclerosis
2013
Introduction In the last few years, it has been increasingly recognized that patients with amyotrophic lateral sclerosis (ALS) frequently suffer of sleep-related complaints, including insomnia, restless legs syndrome, and daytime sleepiness, although, in the past, many of the nocturnal symptoms have been mainly ascribed to chronic respiratory insufficiency and hypoventilation. In addition, excluding few single cases reported, polysomnographic studies did not look for abnormal motor activity during sleep that could be indicative of Rapid Eye Movements (REM) sleep behavior disorder (RBD) and REM sleep without atonia (RSWA), which are highly prevalent in other neurodegenerative disorders with …