Search results for "small"

URBAN RESILIENCE AND WASTE MANAGEMENT: PROPOSALS OF NEW INFRASTRUCTURES FOR URBAN AREAS AND BUILDINGS

2015

La produzione ingente di rifiuti, quale conseguenza di costumi di vita volti allo spreco, rende vulnerabili i sistemi urbani che possono essere sottoposti, in casi emergenziali, a pressioni eccezionali e incontrollate con situazioni prossime al collasso. Un’opportuna e corretta gestione integrata dei rifiuti contribuisce alla resilienza dei sistemi urbani. Perciò si rendono necessarie la pianificazione e la progettazione di nuovi servizi e l’individuazione/integrazione di spazi e dotazioni tecnologiche per incentivare la popolazione a effettuare la raccolta differenziata in modo corretto e costante. Si presentano gli esiti di uno studio svolto in un piccolo centro siciliano. Partendo dalle …

Role of positron emission tomography (PET) in advanced stage non-small cell lung cancer patients treated with cisplatin-based doublets

2008

A Small Special Needs Class or a Smaller Class at the Beginning of the Educational Path?

2016

<p>This article is based on the case study which focuses on the small class (in this article used to describe a small special needs class) operation of one medium-sized Finnish town. In the study an attempt was made to clarify what kind of alternative the small class is to the first grade of general education at the beginning of the child's educational path, what kind of experiences the teachers had of the pupils of the small class, of multi-vocational cooperation and of pupils' integration and success in general education. The results of the study showed that a large part of the pupils who come to the small classes had learning difficulties, and attention and behavioural disorders. I…

Learning Molecular Classes from Small Numbers of Positive Examples Using Graph Grammars

2021

We consider the following problem: A researcher identified a small number of molecules with a certain property of interest and now wants to find further molecules sharing this property in a database. This can be described as learning molecular classes from small numbers of positive examples. In this work, we propose a method that is based on learning a graph grammar for the molecular class. We consider the type of graph grammars proposed by Althaus et al. [2], as it can be easily interpreted and allows relatively efficient queries. We identify rules that are frequently encountered in the positive examples and use these to construct a graph grammar. We then classify a molecule as being conta…

How to untie G-quadruplex knots and why?

2021

International audience; For over two decades, the prime objective of the chemical biology community studying G-quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to obtain mechanistic interpretations. This strategy has been undoubtedly successful, as demonstrated by recent advances. However, these insights have also led to a fundamental rethinking of G4-targeting strategies: due to the prevalence of G4s in the human genome, transcriptome, and ncRNAome (collectively referred to as the G4ome), and their involvement in human diseases, should we continue developing G4-stabilizing ligands or should we invest in designing molecular tools to unfold G4s? Here, …

Natural Products Derived from Traditional Chinese Medicine as Novel Inhibitors of the Epidermal Growth Factor Receptor

2010

The epidermal growth factor receptor (EGFR) has become an important molecular target in cancer therapy. Various small molecules and therapeutic antibodies targeting EGFR family members have been developed during recent years and are established in clinical oncology. However, increasing clinical application of EGFR tyrosine kinase inhibitors has resulted in the development of resistance to EGFR-targeting drugs due to the selection of EGFR-mutated variants. This phenomenon forced the search for novel EGFR inhibitors with activity towards EGFR-mutant tumors. This review describes recent achievements in natural products derived from medicinal plants as novel EGFR inhibitors.

Role of Data Communications in Hybrid Cloud Costs

2011

Rapid adoption of cloud services in recent years has been driven by multiple factors, such as faster time-to-market and improved scalability enabled by public cloud infrastructure. Hybrid clouds, combining the in-house capacities with on-demand capacity of public clouds, achieve both the increased utilization rate of the in-house infrastructure and the limited use of more expensive public cloud, thereby lowering the total costs for the cloud user. In this paper, an analytical model of hybrid cloud costs is introduced, wherein the costs of computing and data communication are taken into account. Using this model, the costefficient division of the computing capacity between the private and th…

Small-Angle Neutron Scattering from Aqueous Solutions of C12E6 and C12E8: Critical Fluctuations and Micellar Growth

1986

Static SANS measurements have been performed on 0.028 M C12E8 in D2O over the temperature range 20–74.2 °C. Little micellar growth is observed; increases in the scattered intensities in the low angle region are due to critical concentration fluctuations of correlation length g. We have also reexamined our SANS data for C12E6 in D2O, in light of other worker’s claims that a sphere-to-cylinder transition in micellar shape is occurring in these solutions. We discuss in detail the inferences about C12E6 micellar size drawn from the results of several different experimental techniques.

Towards Neural Reusable Neuro-inspired Systems

2018

This chapter presents an overview of some key aspects of the neuro-inspired modelling previously discussed, under the new perspective of the neural reuse theory. Here it is envisaged that the excellent capabilities shown by insects with their small neuron number and relatively low brain complexity, as compared to vertebrates, could be justified if some key neural structures are re-used for different behavioural needs. The chapter recalls some examples, found in the literature for addressing specific topics and reformulates them in relation to the neural reuse theory.

Effect of inter-crystal scatter on estimation methods for random coincidences and subsequent correction.

2008

Random coincidences can contribute substantially to the background in positron emission tomography (PET). Several estimation methods are being used for correcting them. The goal of this study was to investigate the validity of techniques for random coincidence estimation, with various low-energy thresholds (LETs). Simulated singles list-mode data of the MADPET-II small animal PET scanner were used as input. The simulations have been performed using the GATE simulation toolkit. Several sources with different geometries have been employed. We evaluated the number of random events using three methods: delayed window (DW), singles rate (SR) and time histogram fitting (TH). Since the GATE simula…