Search results for "soft"

DNA as Building Material at the Nanoscale: From Concepts to Software-aided Design

2017

Transient Hydrogels Mediated by Redox-Switchable Supramolecular Polymerization

2017

Spatial and temporal control in multi-stimuli-responsive materials are critical properties to advance and optimize functional soft matter in order to mimic key features of living systems. In this contribution, I will discuss our methodology in developing non-equilibrium states in supramolecular materials. We have expanded our concept of charge regulated s–sheet self-assembly of alternating hydrophilic and hydrophobic amino acids in order to introduce redox-switchable properties. An interplay of pH- and oxidation-stimuli, promoted by the production of reactive oxygen species (ROS) thus leads to transient supramolecular polymerizations of methionine containing amphiphiles, with tuneable lifet…

Genetic Systems for Monitoring Interactions of Transmembrane Domains in Bacterial Membranes

2013

In recent years several systems have been developed to study interactions of TM domains within the inner membrane of the Gram-negative bacterium Escherichia coli. Mostly, a transmembrane domain of interest is fused to a soluble DNA-binding domain, which dimerizes in E. coli cytoplasm after interactions of the transmembrane domains. The dimeric DNA-binding domain subsequently binds to a promoter/operator region and thereby activates or represses a reporter gene. In 1996 the first bacterial system has been introduced to measure interactions of TM helices within a bacterial membrane, which is based on fusion of a transmembrane helix of interest to the DNA-binding domain of the Vibrio cholerae …

Homocalixpyridines: Ligands Exhibiting High Selectivity in Extraction and Sensor Processes

1998

A novel spherical host architecture, based on pyridine subunits, has been created. It exhibits selective complexing properties toward soft metal ions (right), which have been tested in extraction and sensor processes. The complex-forming behaviour can be tailored by variation of the size of the cavity and by substitution. Homocalixpyridines are interesting in view of their application as selective carriers in separation and sensing techniques.

Music making software programs for children from ages five to twelve

2010

This research classifies the qualities in the existing music creation software programs that enable them to be operated by young users. This is done through comparison of the literature on musical development of children and the examination of the existing software. For the research were selected three fundamentally different pieces of music creation software that potentially provide a wide variety of features. The selected programs are GarageBand, Songsmith and Groovy Music. Each of the three programs has its own strengths in benefiting children s musical development in different ages. What all programs share is the ease of use and a clear interface. Icons of the functions help navigating …

Una questione di software

2012

A gearbox model for processing large volumes of data by using pipeline systems encapsulated into virtual containers

2020

Software pipelines enable organizations to chain applications for adding value to contents (e.g., confidentially, reliability, and integrity) before either sharing them with partners or sending them to the cloud. However, the pipeline components add overhead when processing large volumes of data, which can become critical in real-world scenarios. This paper presents a gearbox model for processing large volumes of data by using pipeline systems encapsulated into virtual containers. In this model, the gears represent applications, whereas gearboxes represent software pipelines. This model was implemented as a collaborative system that automatically performs Gear up (by using parallel patterns…

The Three Steps of Clustering in the Post-Genomic Era: A Synopsis

2011

Clustering is one of the most well known activities in scientific investigation and the object of research in many disciplines, ranging from Statistics to Computer Science. Following Handl et al., it can be summarized as a three step process: (a) choice of a distance function; (b) choice of a clustering algorithm; (c) choice of a validation method. Although such a purist approach to clustering is hardly seen in many areas of science, genomic data require that level of attention, if inferences made from cluster analysis have to be of some relevance to biomedical research. Unfortunately, the high dimensionality of the data and their noisy nature makes cluster analysis of genomic data particul…

Computational cluster validation for microarray data analysis: experimental assessment of Clest, Consensus Clustering, Figure of Merit, Gap Statistic…

2008

Abstract Background Inferring cluster structure in microarray datasets is a fundamental task for the so-called -omic sciences. It is also a fundamental question in Statistics, Data Analysis and Classification, in particular with regard to the prediction of the number of clusters in a dataset, usually established via internal validation measures. Despite the wealth of internal measures available in the literature, new ones have been recently proposed, some of them specifically for microarray data. Results We consider five such measures: Clest, Consensus (Consensus Clustering), FOM (Figure of Merit), Gap (Gap Statistics) and ME (Model Explorer), in addition to the classic WCSS (Within Cluster…

Coesione europea e strategie di soft planning: tracce di una ricentralizzazione dello sviluppo. Alcune evidenze in Sicilia

2018

Le politiche di coesione territoriale dell’Unione europea mettono in discussione i principi dello sviluppo locale. Nonostante la Commissione europea abbia adottato un approccio place-based, sembra che le sue azioni di pianificazione soft si stiano muovendo in direzione di una centralizzazione delle funzioni decisionali. Lo sviluppo del PO FESR 2014-2020 in Sicilia nei settori del turismo e della cultura ne offre una concreta dimostrazione. The territorial cohesion policies of the European Union call into question the principles of local development. Although the European Commission has adopted a place-based approach, it seems that its actions of soft planning are moving towards a centraliza…