Search results for "solu"
showing 10 items of 7577 documents
Carta pastoral del Ilustrísimo Señor D. Fr. Veremundo Arias y Teyxeiro, al clero y pueblo de su diócesis siendo Obispo de Pamplona el 13 de diciembre…
Sermon del viernes tercero de Quaresma, predicado al Rey Nuestro Señor en su Real Capilla el día 24 de febrero del año 1815
Ornamentació tip. aport Filets Text a 1 col Sign.: [ ]8
Liturgia y monarquía. La legitimación del poder monárquico en la Valencia barroca
1993
El estudio de las ceremonias religiosas celebradas en la Valencia del siglo XVII con motivo de acontecimientos relacionados con la Monarquía es el objetivo de este trabajo. Nacimientos, bodas o fallecimientos de reyes, reinas o príncipes son motivo de celebración dada su importancia política. Así, la evolución monárquica interna y la situación internacional del Estado bien merecen una oración. Ésta tiene su razón de ser en el contexto de un pensamiento político basado en la idea del origen divino del poder real, en la estrecha relación entre Monarquía y Religión, y en el marco mental de la espiritualidad barroca. Es éste, por tanto, un recorrido por las formas de expresión de la sacralizaci…
Civilidad y Buen gobierno: la "Policía" en el siglo XVIII
2008
El concepto y la práctica de la "policía" son una de las áreas más importantes desde finales del siglo XVII. Si estudiamos ese concepto y esa práctica podremos ver cómo las monarquías absolutas europeas desarrollan una nueva racionalidad de lo "político". De hecho, ambos términos fueron durante mucho tiempo sinónimos; ambos términos, la "policía" y la "política" en el siglo XVIII, tienen que ver con un ámbito de actuación global. Éste incluía lo material y lo espiritual, las cosas y los hombres, la producción y la ordenación de la riqueza, y también una nueva sociabilidad y una nueva "civilización". Era el arte del "buen gobierno". En este artículo repasamos los diversos modelos de desarrol…
Isocratic and gradient elution in micellar liquid chromatography with Brij-35
2015
Polyoxyethylene(23)lauryl ether (known as Brij-35) is a nonionic surfactant, which has been considered as an alternative to the extensively used in micellar liquid chromatography anionic surfactant sodium lauryl (dodecyl) sulfate, for the analysis of drugs and other types of compounds. Brij-35 is the most suitable nonionic surfactant for micellar liquid chromatography, owing to its commercial availability, low cost, low toxicity, high cloud temperature, and low background absorbance. However, it has had minor use. In this work, we gather and discuss some results obtained in our laboratory with several β-blockers, sulfonamides, and flavonoids, concerning the use of Brij-35 as mobile phase mo…
Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…
2021
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…
Bioaccessibility of calcium, iron and zinc from three legume samples
2004
Legumes can be a source of mineral elements but also of antinutritional factors which can affect their absorption. An in vitro method including gastrointestinal digestion was used to estimate mineral bioavailability. Soluble (bioaccessible) and insoluble calcium, iron and zinc from white beans, chickpeas and lentils were determined after gastrointestinal digestion. The influence of the original sample weight on the soluble mineral fraction was also estimated. The results obtained show that white beans are the legumes with the highest bioaccessible calcium and iron contents. Lentils have a high iron content but its bioaccessibility is much lower than that of iron from white beans and chickpe…
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro ex…
2014
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence…
Effect of simulated gastrointestinal digestion on plant sterols and their oxides in enriched beverages
2013
Abstract This study evaluates the bioaccessibility (percentage of soluble compound available for absorption) of plant sterols (PS) and their oxides (phytosterol oxidation products, POPs) after simulated gastrointestinal digestion in fruit (Fb), milk (M) and fruit-based milk beverages with (FbM a ) or without (FbM b ) tangerine juice. In beverages and their bioaccessible fraction (BF), campesterol, campestanol, stigmasterol, β-sitosterol and sitostanol were detected. Bioaccessibility of total PS ranged between 2.62 and 6.48%, FbM b yielding the highest value, followed by FbM a > Fb > M. Campesterol/campestanol were the most bioaccessible PS. Only oxides of β-sitosterol were detected in beve…
Effect of cooking on oxalate content of pulses using an enzymatic procedure.
2003
An enzymatic method proposed for the determination of oxalate in urine is adapted for the estimation of soluble oxalate content in beans, chickpeas and lentils. Oxalates were extracted in water by refluxing for 2 h. The method is based on the oxidation of oxalate by the oxidase and the determination of the resulting hydrogen peroxide, which in presence of peroxidase, 3-methyl-2 benzotiazinolone and 3-dimethylamino benzoic, gives an indamine compound with an absorption maximum at 590 nm. The linearity (from 0.015 to 0.6 mM) of the method is adequate to the analysis of oxalate contents in pulses, and the inter-day precision of the method expressed as relative standard deviation was good (3.01…