Search results for "solu"

Randomized Trial : D-Glyceric Acid Activates Mitochondrial Metabolism in 50–60-Year-Old Healthy Humans

2021

Background: Based on earlier studies, natural metabolite D-glyceric acid (DGA) does not seem to play any role in whole-body metabolism. Nevertheless, one ethanol oxidation-related rat study with controversial results raised our interest. According to preparatory studies for the regulatory approval of DGA, some highly conserved mechanism seems to subtly activate the cellular energy metabolism. Therefore, the present 25-days double-blind human study with placebo control was initiated. Purpose: The main target in the present study with 27 healthy 50–60-year-old human volunteers was to find out whether an “acute” 4-days and a longer 21-days exogenous DGA regimen caused moderate activation of th…

Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments

2021

Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting quality of life and overall survival in cancer patients. Pre-clinical studies have shown that blocking activin receptor type 2 (ACVR2) or its ligands and their downstream signaling can preserve muscle mass in rodents bearing experimental cancers, as well as in chemotherapy-treated animals. In tumor-bearing mice, the prevention of skeletal and respiratory muscle wasting was also associated with improved survival. However, the definitive proof tha…

La preservación del favor filii en supuestos de ruptura de la convivencia de los acogedores, tutores o guardadores del menor

2021

Cuando la guarda del menor por parte de los progenitores no es posible y esta es atribuida de forma conjunta a dos personas convivientes que posteriormente cesan dicha convivencia, resulta necesario determinar cuál de ellas va a ejercer a partir de ese momento las funciones inherentes a dicha guarda. Las posibles soluciones dependerán de si se trata de un supuesto de acogimiento, de tutela o de siempre guarda. When care of the child by the parents is not possible and is attributed jointly to two people living together who subsequently stop living together, it is necessary to determine which of them will exercise the functions inherent to the care from that moment on. The possible solutions …

Constant sign and nodal solutions for parametric anisotropic $(p, 2)$-equations

2021

We consider an anisotropic ▫$(p, 2)$▫-equation, with a parametric and superlinear reaction term.Weshow that for all small values of the parameter the problem has at least five nontrivial smooth solutions, four with constant sign and the fifth nodal (sign-changing). The proofs use tools from critical point theory, truncation and comparison techniques, and critical groups. Spletna objava: 9. 9. 2021. Abstract. Bibliografija: str. 1076.

Autophagy is induced by resistance exercise in young men but unfolded protein response is induced regardless of age

2018

Aim Autophagy and unfolded protein response (UPR) appear to be important for skeletal muscle homoeostasis and may be altered by exercise. Our aim was to investigate the effects of resistance exercise and training on indicators of UPR and autophagy in healthy untrained young men (n = 12, 27 ± 4 years) and older men (n = 8, 61 ± 6 years) as well as in resistance‐trained individuals (n = 15, 25 ± 5 years). Methods Indicators of autophagy and UPR were investigated from the muscle biopsies after a single resistance exercise bout and after 21 weeks of resistance training. Results Lipidated LC3II as an indicator of autophagosome content increased at 48 hours post‐resistance exercise (P < .05) and …

PROGETTARE L’ADATTAMENTO. Resilienze di agricoltura urbana nel contesto europeo

2022

I crescenti fenomeni legati al cambiamento climatico spingono le città a sviluppare piani di resilienza che possano rispondere in termini di sostenibilità ambientale, sociale ed economica. Le strategie nature-based possono rappresentare una soluzione; tra queste l’agricoltura urbana può contribuire ad aumentare la resilienza dei tessuti urbani europei. Questa attività è stata più volte oggetto di interesse in periodi di crisi come impegno comunitario dai caratteri sociali, oltre che produttivi ed educativi. Attraverso un excursus storico e una successiva analisi di casi studio contemporanei, il paper fornisce strumenti progettuali per intervenire nel costruito con strategie che spaziano dal…

A Religious End of Metaphysics? Heidegger, Meillassoux and the Question of Fideism

2016

SST Comparison of AVHRR and MODIS Time Series in the Western Mediterranean Sea

2020

La temperatura de la superficie del mar (SST) es un parámetro clave para comprender los procesos atmosféricos y oceánicos. Desde finales de la década de 1980, las imágenes de satélite infrarrojas se han utilizado para complementar los registros in situ para estudiar la variabilidad temporal y espacial de la SST. El radiómetro avanzado de muy alta resolución (AVHRR) del satélite de la Administración Nacional Oceánica y Atmosférica (NOAA) fue el primer sensor utilizado con éxito para calcular la SST después del desarrollo y validación del algoritmo de corrección atmosférica conocido como 'ventana dividida'. Más recientemente, el espectrorradiómetro de imágenes de resolución MODERADA (MODIS) a…

Valkosolupitoisuuksien bayesilainen mallintaminen lasten leukemian ylläpitohoidossa

2018

Lasten akuutin lymfoblastileukemian ylläpitovaiheen hoidossa tehtävät lääkeannostuspäätökset pohjataan nykyisin potilaan veren valkosolupitoisuuteen, joka on hoidon tehokkuudesta kertova tekijä. Potilaalle sopiva lääkeannostus on hoidon onnistumisen ja turvallisuuden kannalta tärkeä, mutta sen löytäminen on vaikeaa, sillä annettu lääkitys näkyy valkosolupitoisuudessa viiveellä, ja potilaiden elimistön reagointi lääkitykseen on yksilöllistä. Sopivan lääkeannostuksen löytämistä hankaloittavat myös hoidonaikaiset tulehdukset, jotka voivat muuttaa valkosolupitoisuutta hetkellisesti. Työ käsittelee akuuttiin lymfoblastileukemiaan sairastuneiden suomalaisten potilaiden veren valkosolupitoisuuden …

Main protein component of high density lipoprotein, apolipoprotein A1, modulates leukocyte cell respiration

2015

HDL:n (high density lipoprotein) pääproteiinikomponentin, apolipoproteiini A1:n (ApoA1), on todettu lisäävän glykolyysia ja oksidatiivista fosforylaatiota hiiren luurankolihassoluissa. ApoA1:llä oletetaan myös olevan merkittävä rooli lihaksen normaalissa aineenvaihdunnassa ja siihen liittyvissä sairauksissa. ApoA1 vaikuttaa leukosyyttien aktivaatioon ja jakautumiseen säätelemällä solun sisäistä kolesterolitasoa. Nämä muutokset vaikuttavat myös solun aineenvaihduntaan. ApoA1:n suoranaista vaikutusta leukosyyttien soluhengitykseen ei kuitenkaan ole aiemmin tutkittu. Aiemmin on esitetty, että leukosyyttejä voitaisiin käyttää biomarkkerina kuvaamaan muutoksia mitokondrioiden toiminnassa aineenv…