Search results for "solvation"

showing 10 items of 157 documents

Unveiling the Ionic Diels-Alder Reactions within the Molecular Electron Density Theory

2021

The ionic Diels–Alder (I-DA) reactions of a series of six iminium cations with cyclopentadiene have been studied within the Molecular Electron Density Theory (MEDT). The superelectrophilic character of iminium cations, ω &gt

Steric effectsCyclopentadienePharmaceutical ScienceIonic bonding010402 general chemistry01 natural sciencesArticleAnalytical Chemistrychemistry.chemical_compoundQD241-441Computational chemistryDrug Discoveryionic Diels–Alder reactionsReactivity (chemistry)Physical and Theoretical Chemistryorganic_chemistry010405 organic chemistryChemistryOrganic ChemistrySolvationCationic polymerizationMolecular Electron Density TheoryIminiumiminium cationsElectron localization function3. Good health0104 chemical sciencesChemistry (miscellaneous)asynchronicityglobal electron density transfersuperelectrophilesMolecular Medicine
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Gas-phase and solution basicities of some alkyl 2,6-dialkylphenyl ketones: A comparative analysis

2000

Abstract The gas-phase basicity of a number of alkyl 2,6-dialkylphenyl ketones (2,6-R2C6H3COR′) has been found to be almost insensitive to structural variations, as a result of a compensation of steric and electronic effects associated with the bulkiness and to the polarizability, respectively, of R and/or R′. On the contrary, the basicity in concentrated sulfuric acid undergoes, along the same series of compounds, a variation of nearly 8 pK units, as a consequence of steric inhibition of solvation of the protonated carbonyl as the main effect played by R and/or R′. The results in the condensed phase agree very nicely with recent findings relevant to some 4-substituted 2,6-dimethylacetophen…

Steric effectschemistry.chemical_classificationChemistryStereochemistryArylOrganic ChemistrySolvationProtonationBiochemistryMedicinal chemistrychemistry.chemical_compoundPolarizabilityPhase (matter)Drug DiscoveryElectronic effectAlkyl
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ChemInform Abstract: Gas-Phase and Solution Basicities of Some Alkyl 2,6-Dialkylphenyl Ketones: A Comparative Analysis.

2000

Abstract The gas-phase basicity of a number of alkyl 2,6-dialkylphenyl ketones (2,6-R2C6H3COR′) has been found to be almost insensitive to structural variations, as a result of a compensation of steric and electronic effects associated with the bulkiness and to the polarizability, respectively, of R and/or R′. On the contrary, the basicity in concentrated sulfuric acid undergoes, along the same series of compounds, a variation of nearly 8 pK units, as a consequence of steric inhibition of solvation of the protonated carbonyl as the main effect played by R and/or R′. The results in the condensed phase agree very nicely with recent findings relevant to some 4-substituted 2,6-dimethylacetophen…

Steric effectschemistry.chemical_classificationchemistry.chemical_compoundchemistryPolarizabilityArylPhase (matter)SolvationElectronic effectProtonationGeneral MedicineMedicinal chemistryAlkylChemInform
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Azide Binding Controlled by Steric Interactions in Second Sphere. Synthesis, Crystal Structure, and Magnetic Properties of [Ni II 2 (L)(μ 1,1 -N 3 )]…

2016

International audience; The dinuclear Ni-II complex [Ni-2(L-2)][ClO4](2) (3) supported by the 28-membered hexaaza-dithiophenolate macro-cycle (L-2)(2-) binds the N-3(-) ion specifically end-on yielding [Ni-2(L-2)(mu(1,1)-N-3)] [ClO4] (7) or [Ni-2(L-2)(mu(1,1)-N-3)][BPh4] (8), while the previously reported complex [Ni2L1(mu(1,3)-N-3)][ClO4] (2) of the 24-membered macrocycle (L-1)(2-) coordinates it in the end-to-end fashion. A comparison of the X-ray structures of 2, 3, and 7 reveals the form-selective binding of complex 3 to be a consequence of its preorganized, channel-like binding pocket, which accommodates the azide anion via repulsive CH center dot center dot center dot pi interactions …

Steric effectsequilibrium-constantsStereochemistrytransition-metal-complexesCrystal structure010402 general chemistry01 natural sciences[ CHIM ] Chemical Sciencessolvation free-energyInorganic Chemistrychemistry.chemical_compoundtetranuclear nickel(ii) complexes[CHIM.CRIS]Chemical Sciences/CristallographyAntiferromagnetismMolecule[CHIM.COOR]Chemical Sciences/Coordination chemistryPhysical and Theoretical Chemistrymu-azidoEquilibrium constantmolecular-structure010405 organic chemistryChemistryLigandni-ii[ CHIM.INOR ] Chemical Sciences/Inorganic chemistryend-to-end0104 chemical sciencesexchange interactionsCrystallographyAzideGround stateorbital interactions[ CHIM.RADIO ] Chemical Sciences/Radiochemistry
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Binding abilities of a chiral calix[4]resorcinarene: a polarimetric investigation on a complex case of study

2017

Polarimetry was used to investigate the binding abilities of a chiral calix[4]resorcinarene derivative, bearing L-proline subunits, towards a set of suitably selected organic guests. The simultaneous formation of 1:1 and 2:1 host–guest inclusion complexes was observed in several cases, depending on both the charge status of the host and the structure of the guest. Thus, the use of the polarimetric method was thoroughly revisited, in order to keep into account the occurrence of multiple equilibria. Our data indicate that the stability of the host–guest complexes is affected by an interplay between Coulomb interactions, π–π interactions, desolvation effects and entropy-unfavorable conformatio…

Supramolecular chemistryPolarimetryhost–guest complexes010402 general chemistry01 natural scienceshost-guest complexesFull Research Papersupramolecular chemistrylcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistryComputational chemistryp-nitroanilinesDesolvationlcsh:Sciencepolarimetrycalix[4]resorcinarene010405 organic chemistryChemistryOrganic ChemistryHost-guest complexeSettore CHIM/06 - Chimica OrganicaResorcinarene0104 chemical sciencesChemistrylcsh:QP-nitroanilineDerivative (chemistry)Beilstein Journal of Organic Chemistry
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Electrostatic interaction of a solute with a continuum. Improved description of the cavity and of the surface cavity bound charge distribution.

1987

Algorithms for a finer description of cavities in continuous media and for a more efficient selection of sampling points on the cavity surface are described. Applications to the evaluation of solute surface and volume and to the calculation of the solute-solvent electrostatic interaction energy, as well as of the cavitation energy are shown as examples.

Surface (mathematics)Computational MathematicsVolume (thermodynamics)ChemistryCavitationContinuum (design consultancy)SolvationPhysical chemistryCharge densityGeneral ChemistryInteraction energyMolecular physicsEnergy (signal processing)Journal of Computational Chemistry
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A thermodynamic approach to study hydrogen-bonding interactions in solvent/solvent/polymer ternary systems

2007

Abstract A thermodynamic approach based on both the classical Flory–Huggins (FH) formalism and the association equilibria (AE) theory has been developed to study the solubility properties of a system formed by a proton-donor solvent (A), a proton-acceptor solvent (B) and a proton-acceptor polymer (C). The miscibility of this ternary system is attained by competitive specific interactions via hydrogen-bonding established between the hydroxyl and carbonyl interacting groups of either solvent–solvent (AB) or solvent–polymer (AC) system components. The binary AB and AC specific interactions and their dependence with the system composition as well as with the extent of the association equilibriu…

Ternary numeral systemPolymers and PlasticsChemistryOrganic ChemistryIntermolecular forceSolvationGeneral Physics and AstronomyEntropy of mixingGibbs free energySolventsymbols.namesakeMaterials ChemistrysymbolsPhysical chemistrySolubilityTernary operationEuropean Polymer Journal
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Predictability of properties of ternary systems solvent/solvent/polymer from interaction parameters of the binary systems—III. Analysis of binary pot…

1990

Abstract The assumption that the ternary parameter, g τ , and its derivative with respect to polymer concentration, ( ∂g τ / ∂φ 3 ) μ 1 , φ 3 → 0 , can be described by three binary interaction parameters, g o i 3 ( i = 1, 2) and g 12 , implies that these must be independent functions. This feature has been demonstrated by using g o i 3 values obtained from A/B/polymer(P) and C/D/P ternary polymer systems to predict the ternary properties, namely preferential solvation (λ), second virial coefficient ( A 2 ) and intrinsic viscosity ([η]), of a A/C/P ternary system. Two distinct polymers, polystyrene(PS) and poly(dimethylsiloxane)(PDMS), have been utilized in three solvent mixtures, benzene(BZ…

Ternary numeral systemPolymers and PlasticsCyclohexaneIntrinsic viscosityOrganic ChemistryButanoneSolvationGeneral Physics and AstronomyFlory–Huggins solution theorychemistry.chemical_compoundVirial coefficientchemistryPolymer chemistryMaterials ChemistryPhysical chemistryTernary operationEuropean Polymer Journal
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Protonation equilibria of some ortho-substituted and annelated aryl and thiophen-2-yl and -3-yl ketones

2001

For some phenyl- (1–8) and thiophen-2-yl (9–11) and thiophen-3-yl (12–14) ketones quantum-mechanical (PM3) calculations have been performed, and for compounds 2, 3, 5–8, 10–14 protonation equilibria have been determined. Phenyl ketones have similar values for the m* parameter and show good linear correlation between the proton affinities calculated in the gas phase and the measured pKBH+ values, which in turn parallel the trend for the calculated carbonyl–phenyl ring dihedral angle. It appears that the differences in basicity are governed essentially by “internal” factors (carbonyl–ring conjugation), while the base–conjugate acid differential solvation is not significantly affected by struc…

Turn (biochemistry)Solventchemistry.chemical_compoundchemistryStereochemistryArylSolvationProtonationDihedral angleRing (chemistry)Medicinal chemistryAffinities
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Theoretical Study of the Electronic Spectrum of Imidazole

1996

The complete active space (CAS) self-consistent field (SCF) method and multireference second-order perturbation theory (CASPT2) have been used to study the electronic spectrum of imidazole and the imidazolium ion. The calculations comprise a large number of, both singlet and triplet, valence and Rydberg excited states. A newly developed continuum model has been used to compute solvatochromic shifts. In the gas phase the first and second π → π* excited singlet valence states of imidazole are computed at 6.72 and 7.15 eV, and they shift to 6.32 and 6.53 eV upon solvation. The gas-phase values are somewhat too large (≈0.3 eV) due to an erroneous valence−Rydberg mixing in the CASSCF wave functi…

Valence (chemistry)ChemistryGeneral EngineeringSolvationIonsymbols.namesakeAbsorption bandExcited stateRydberg formulasymbolsSinglet stateComplete active spacePhysical and Theoretical ChemistryAtomic physicsThe Journal of Physical Chemistry
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