Search results for "sort"

1,2,4-Oxadiazole topsentin analogs as staphylococcal biofilm inhibitors targeting the bacterial transpeptidase sortase A

2020

The inhibition or prevention of biofilm formation represents an emerging strategy in the war against antibiotic resistance, interfering with key players in bacterial virulence. This approach includes the inhibition of the catalytic activity of transpeptidase sortase A (Srt A), a membrane enzyme responsible for covalently attaching a wide variety of adhesive matrix molecules to the peptidoglycan cell wall in Gram-positive strains. A new series of seventeen 1,2,4-oxadiazole derivatives was efficiently synthesized and screened as potential new anti-virulence agents. The ability of inhibiting biofilm formation was evaluated against both Gram-positive and Gram-negative pathogens. Remarkably, all…

Learned Sorted Table Search and Static Indexes in Small-Space Data Models

2023

Machine-learning techniques, properly combined with data structures, have resulted in Learned Static Indexes, innovative and powerful tools that speed up Binary Searches with the use of additional space with respect to the table being searched into. Such space is devoted to the machine-learning models. Although in their infancy, these are methodologically and practically important, due to the pervasiveness of Sorted Table Search procedures. In modern applications, model space is a key factor, and a major open question concerning this area is to assess to what extent one can enjoy the speeding up of Binary Searches achieved by Learned Indexes while using constant or nearly constant-space mod…

Chiral Self‐Sorting of trans ‐Chelating Chiral Ligands upon Formation of Pd II Complexes (Eur. J. Inorg. Chem. 15/2014)

2014

Chiral Self-Sorting of trans-Chelating Chiral Ligands upon Formation of PdII Complexes

2014

Invited for the cover of this issue is the group of Arne Lutzen at the University of Bonn, Germany. The cover image shows two dissymmetric bis(3-pyridyl) ligands based on a planar chiral pseudo-ortho-disubstituted [2.2]paracyclophane scaffold. Upon forming a mononuclear [ML2] complex with palladium(II) ions, these ligands act in a trans-chelating manner and undergo complete chiral self-sorting.

Cholesterol Dependence of Collagen and Echovirus 1 Trafficking along the Novel α2β1 Integrin Internalization Pathway

2013

We have previously shown that soluble collagen and a human pathogen, echovirus 1 (EV1) cluster α2β1 integrin on the plasma membrane and cause their internalization into cytoplasmic endosomes. Here we show that cholesterol plays a major role not only in the uptake of α2β1 integrin and its ligands but also in the formation of α2 integrin-specific multivesicular bodies (α2-MVBs) and virus infection. EV1 infection and α2β1 integrin internalization were totally halted by low amounts of the cholesterol-aggregating drugs filipin or nystatin. Inhibition of cholesterol synthesis and accumulation of lanosterol after ketoconazole treatment inhibited uptake of collagen, virus and clustered integrin, an…

Festivas demostraciones, con que celebró la ... ciudad de Alicante, los reales desposorios de su Magestad, con ... Doña Isabel Farnesse de Neoburg,…

1715

Sig. A6 Port. orlada. - Reclams. - Capital grav., banda i ornament tip. floral al final

Festivas demostraciones, con que celebró la ... ciudad de Alicante, los reales desposorios de su Magestad, con ... Doña Isabel Farnesse de Neoburg, P…

Sig. A6 Port. orlada. - Reclams. - Capital grav., banda i ornament tip. floral al final

Nueva relacion en un curioso romance, que refiere y declara las plausibles y solemnes fiestas reales de toros y cañas, que se delebraron en esta ... …

Peu d'impremta pres del colofó Data d'impressió deduïda del títol Text a dues columnes Signatures: [ ]2 Escut real xilogràfic en pàgina [1

The Jewish doctors involved in the development of health resorts in eastern Galicia at the late 19th and early 20th century (Central and Eastern Euro…

2018

Summary Background The involvement of Jewish doctors and scientists in the development of health resorts in eastern Galicia (part of the Austrian monarchy after 1772, and since 1918 as part of independent Poland, now part of Ukraine) is unquestionable; however, awareness of this fact is not that common. Meanwhile, also due to their work and activity, small borderland resorts became important medical, cultural and social centers of the region. The involvement of Jewish doctors in the development of Galician health resorts resulted from, among others, the rich and multi-layered tradition and integration of Judaism with the hygiene regulations and moral principles of the religion. The eastern …

Microbial Dynamics between Yeasts and Acetic Acid Bacteria in Kombucha: Impacts on the Chemical Composition of the Beverage.

2020

Kombucha is a traditional low-alcoholic beverage made from sugared tea and transformed by a complex microbial consortium including yeasts and acetic acid bacteria (AAB). To study the microbial interactions and their impact on the chemical composition of the beverage, an experimental design with nine couples associating one yeast strain and one AAB strain isolated from original black tea kombucha was set up. Three yeast strains belonging to the genera Brettanomyces, Hanseniaspora, and Saccharomyces and three strains of Acetobacter and Komagataeibacter species were chosen. Monocultures in sugared tea were analyzed to determine their individual microbial behaviors. Then, cultivation of the ori…