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High Wage Workers Match with High Wage Firms: Clear Evidence of the Effects of Limited Mobility Bias
2012
Positive assortative matching implies that high productivity workers and firms match together. However, there is almost no evidence of a positive correlation between the worker and firm contributions in two-way fixed-effects wage equations. This could be the result of a bias caused by standard estimation error. Using German social security records we show that the effect of this bias is substantial in samples with limited inter-firm movement. The correlation between worker and firm contributions to wage equations is unambiguously positive.
Does Non-Domination Imply Freedom? A Discussion of the Neorepublican Conception of Freedom
2018
Conceptual discussion is an often underrated but important matter: Concepts provide the vantage point from which we identify and sort relevant aspects of reality (Ladwig 2009: 20-21). For political theorists – and political scientists more generally – “power” and “freedom” are especially important concepts for making sense of political phenomena. One important contribution to the debate regarding these concepts is Ruth Zimmerling’s book Influence and Power (2005).
Our Progress Towards Virtue
2015
This chapter is about how we can improve our rational abilities, i.e. make progress towards virtue. I first show that, according to Chrysippus, the natural properties of children are usually corrupted in three ways when they grow up and that adults therefore can make progress only by solving their inner conflicts, becoming more steadfast in their practical reasoning, and improving their self-understanding. So I argue that the main remedy against corruption is to study philosophy. I detail how we can acquire a better self-understanding by studying physics and how we can cure the mind of its inconsistencies by studying logic. I also argue that ethics prepares the mind for an active life in wh…
Mating strategies and resulting patterns in mate guarding crustaceans : an empirical and theoretical approach
2012
Because of strong costs associated with each mating event, females are usually not as available for reproduction as males at any given time. Males are therefore in competition with each other for access to receptive females, hence leading to strong sexual selection. One textbook case of such a mating system occurs in moulting crustaceans where females can only be fertilized during a short period following their moult. This has favoured the evolution male strategies to monopolize females before their period of receptivity. Such a precopulatory mate guarding is widespread among many taxa and represents one of the most striking example of males’ competitive traits favoured by sexual selection.…
Turning exercises into problems: An experimental study with teachers in training
1990
The traditional concept of ‘problem’, as frequently exemplified by the paper‐and‐pencil exercises provided in physics textbooks, is examined and criticized for its lack of a truly scientific approach. The presentation of problems in this way, it is suggested, lies at the root of pupils’ and even teachers’ failure to solve simple exercises successfully. It is proposed that by a process of ‘reflective deconditioning’ it is possible to break down the preconceptions of physics teachers in training and help them to recast familiar situations in such a way that true problem solving is possible. A seminar designed to bring about this sort of change is described. Responses to a series of pre‐ and p…
Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry.
2008
TAP is responsible for transferring cytosolic peptides into the ER, where they can be loaded onto MHC molecules. Deletion of TAP results in a drastic reduction of MHC class I surface expression and alters the presented peptide pattern. This key molecule in antigen processing is tackled by several viruses and lost in some tumors, rendering the altered cells less vulnerable to T cell-based immune surveillance. Using the TAP-deficient cell line LCL721.174 and its TAP-expressing progenitor cell line LCL721.45, we identified and quantified more than 160 HLA ligands, 50 of which were presented TAP-independently. Peptides which were predominantly presented on the TAP-deficient LCL721.174 cell line…
Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation
1995
Processing of the hepatitis C virus polyprotein is mediated by host cell signalases and at least two virally encoded proteinases. Of these, the serine-type proteinase encompassing the amino-terminal one-third of NS3 is responsible for cleavage at the four sites carboxy terminal of NS3. The activity of this proteinase is modulated by NS4A, a 54-amino-acid polyprotein cleavage product essential for processing at the NS3/4A, NS4A/4B, and NS4B/5A sites and enhancing cleavage efficiency between NS5A and NS5B. Using the vaccinia virus-T7 hybrid system to express hepatitis C virus polypeptides in BHK-21 cells, we studied the role of NS4A in proteinase activation. We found that the NS3 proteinase a…
CandidaDB: a genome database for Candida albicans pathogenomics.
2004
CandidaDB is accessible at http://genolist.pasteur.fr/CandidaDB.; International audience; CandidaDB is a database dedicated to the genome of the most prevalent systemic fungal pathogen of humans, Candida albicans. CandidaDB is based on an annotation of the Stanford Genome Technology Center C.albicans genome sequence data by the European Galar Fungail Consortium. CandidaDB Release 2.0 (June 2004) contains information pertaining to Assembly 19 of the genome of C.albicans strain SC5314. The current release contains 6244 annotated entries corresponding to 130 tRNA genes and 5917 protein-coding genes. For these, it provides tentative functional assignments along with numerous pre-run analyses th…
Extracellular vesicles from parasitic helminths contain specific excretory/secretory proteins and are internalized in intestinal host cells.
2012
The study of host-parasite interactions has increased considerably in the last decades, with many studies focusing on the identification of parasite molecules (i.e. surface or excretory/secretory proteins (ESP)) as potential targets for new specific treatments and/or diagnostic tools. In parallel, in the last few years there have been significant advances in the field of extracellular vesicles research. Among these vesicles, exosomes of endocytic origin, with a characteristic size ranging from 30-100 nm, carry several atypical secreted proteins in different organisms, including parasitic protozoa. Here, we present experimental evidence for the existence of exosome-like vesicles in parasitic…
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample
2011
Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). OBJECTIVES: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions…