Search results for "space"

LANGUAGE AND SPACE IN WILLIAMS SYNDROME

2010

Hybridizing large neighborhood search and exact methods for generalized vehicle routing problems with time windows

2021

International audience; Delivery options are at the heart of the generalized vehicle routing problem with time windows (GVRPTW) allowing that customer requests are shipped to alternative delivery locations which can also have different time windows. Recently, the vehicle routing problem with delivery options was introduced into the scientific literature. It extends the GVRPTW by capacities of shared locations and by specifying service-level constraints defined by the customers' preferences for delivery options. The vehicle routing problem with delivery options also generalizes the vehicle routing problem with home roaming delivery locations and the vehicle routing problem with multiple time…

Localization of Viral Epitope-Specific CD8 T Cells during Cytomegalovirus Latency in the Lungs and Recruitment to Lung Parenchyma by Airway Challenge…

2021

Interstitial pneumonia is a life-threatening clinical manifestation of cytomegalovirus infection in recipients of hematopoietic cell transplantation (HCT). The mouse model of experimental HCT and infection with murine cytomegalovirus revealed that reconstitution of virus-specific CD8+ T cells is critical for resolving productive lung infection. CD8+ T-cell infiltrates persisted in the lungs after the establishment of latent infection. A subset defined by the phenotype KLRG1+CD62L− expanded over time, a phenomenon known as memory inflation (MI). Here we studied the localization of these inflationary T effector-memory cells (iTEM) by comparing their frequencies in the intravascular and transm…

Association of Arthroscopically-Assisted Latissimus Dorsi Tendon Transfer with Implantation of a Subacromial Balloon Spacer for Patients with Irrepar…

2022

Purpose. Massive irreparable posterosuperior rotator cuff tears in an active population, resulting in a pseudo-paralytic shoulder, pose a challenge for the orthopaedic surgeon. In an effort to avoid or delay arthroplasty surgery, other surgical strategies such as arthroscopically-assisted latissimus dorsi transfer (aLDT) or the implantation of a subacromial spacer (SAS) can be considered. The aim of the present study is to associate, for the first time, these two surgical procedures in order to demonstrate the surgical feasibility and the effectiveness of their synergistic biomechanical effect. Methods. The study group consisted of patients who underwent aLDT for a massive irreparable poste…

Indo-French High-resolution Thermal Infrared Space Mission for Earth Natural Resources Assessment and Monitoring -Concept and Definition of TRISHNA

2019

The Indian and French Space Agencies, ISRO and CNES, have conceptualized a space-borne Thermal Infrared Reflectance (TIR) mission, TRISHNA (Thermal infRared Imaging Satellite for High-resolution Natural Resource Assessment). The primary design drivers of TRISHNA are the monitoring of (i) terrestrial water stress and use, and of (ii) coastal and continental water. A suit of four TIR bands and six optical bands is planned. The TIR bands will be centred at 8.6 μm, 9.1 μm, 10.3 μm and 11.5 μm to provide noon-night global observations at 57m nadir resolution over land and coastal regions. The field of view (FOV) is ±34° and the orbit of 761&thin…

Făgăraș as Jerusalem? Interethnic and interreligious ethos in Transylvania

2017

The study presents Transylvania as a space of ethnic-religious tolerance, having as a case studythe image of the town Făgăraș, as depicted in Eginald Schlattner’s novels. This space appearsas one of a heavenly nuance, based on a long tradition of coexistence of the members ofdifferent ethnic groups and religions. However, the inter-war and post-war period means theemergence of new challenges posed by the confrontation with the harmful effects of the twoideologies: Nazism and Communism. In this way, the dramas of the socio-historical contextinterweave with elements forming young Eginald. They will remain a constant in the writer’slife, offering Făgăraș the role of a forming educational array…

Op art et roman virtuel : correspondances entre Escher et Perec

2012

Op art et roman virtuel : correspondances entre Escher et Perec Les structures mathématiques, la notion de réalité comme « humaine illusion », le défi à l’infini et la structure énigmatique qui donne aux œuvres eschériennes la même structure que celle d’un roman policier permettent d’établir des convergences significatives entre le graveur hollandais et Georges Perec. Dans certaines œuvres de Perec, en effet, il est possible de remarquer des références explicites au graveur bien qu’elles constituent la traduction visuelle de l’angoisse du « retour du semblable », du « retour involontaire au même point ». Mais Perec ne se limite pas seulement à citer Escher, puisque certaines de ses œuvres c…

Parametric uncertainty or hydrological changes?

2014

Abstract. The model calibration is the way of hydrologists for searching also a physical interpretation of complex interactions acting within a basin. Actually, it can be frequently noticed how model calibration performed on a given time-window may converge to a point in the parameter space that could be distant from another obtainable calibration of the model in the same basin but considering a different time window. Is that again parametric uncertainty or does the trajectory in the parametric space relate about to a slow hydrological basin change? This paper depicts a possible path for detecting changes' signatures in a streamflow time series. In particular, the paper seeks to draw a way …

Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space

2019

Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epitope immunogenicity, here we propose a supervised machine learning framework generating probabilistic estimates of immunogenicity, termed "immunogenicity scores," based on the numerical features computed through sequence-based simulation approximating the molecular scanning process of peptides presented onto major histocompatibility complex (MHC) by the human T cell receptor (T…

Utebarnehager – et sted for demokratisk praksis?

2013

The questions in the title is posed to discuss how an outdoor kindergarten space is contextualized and understood by those who are staying there. Nature is often seen as an especially open space, free from strong guidelines and structures. Being part of an educational practice gives the place new structures. The activities the children participate in and the employees expressed attitudes and practices are part of different discourses, which give certain limits or possibilities for what is going on at the Hut, and thus influence a democratic practice. Especially children’s play activities represent an opposition to the adult’s framing of the place. Democracy presupposes some frames, but if t…