Search results for "speckles"
showing 5 items of 5 documents
Loss of ISWI Function in Drosophila Nuclear Bodies Drives Cytoplasmic Redistribution of Drosophila TDP-43
2018
Over the past decade, evidence has identified a link between protein aggregation, RNA biology, and a subset of degenerative diseases. An important feature of these disorders is the cytoplasmic or nuclear aggregation of RNA-binding proteins (RBPs). Redistribution of RBPs, such as the human TAR DNA-binding 43 protein (TDP-43) from the nucleus to cytoplasmic inclusions is a pathological feature of several diseases. Indeed, sporadic and familial forms of amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration share as hallmarks ubiquitin-positive inclusions. Recently, the wide spectrum of neurodegenerative diseases characterized by RBPs functions’ alteration and loss was coll…
ISWI ATP-dependent remodeling of nucleoplasmic ω-speckles in the brain of Drosophila melanogaster.
2017
Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to the RNA-binding proteins family. They are involved in processing heterogeneous nuclear RNAs (hnRNAs) into mature mRNAs. These proteins participate in every step of mRNA cycle, such as mRNA export, localization, translation, stability and alternative splicing. At least 14 major hnRNPs, which have structural and functional homologues in mammals, are expressed in Drosophila melanogaster. Until now, six of these hnRNPs are known to be nucleus-localized and associated with the long non-coding RNA (lncRNA) heat shock responsive ω (hsrω) in the omega speckle compartments (ω-speckles). The chromatin remodeler ISWI is the catalytic subunit …
Shock-induced complex phase-space dynamics of strongly turbulent flows
2017
Shock waves have been thoroughly investigated during the last century in many different branches of physics. In conservative (Hamiltonian) systems the shock singularity is regularized by weak wave dispersion, thus leading to the formation of a rapidly and regular oscillating structure, usually termed in the literature dispersive shock wave (DSW), see e.g. [1]. Here, we show that this fundamental singular process of DSW formation can break down in a system of incoherent nonlinear waves. We consider the strong turbulent regime of a system of nonlocal nonlinear optical waves. We report theoretically and experimentally a characteristic transition: Strengthening the nonlocal character of the non…
Impact of self-steepening on incoherent dispersive spectral shocks and collapse-like spectral singularities
2014
International audience; Incoherent dispersive shock waves and collapselike singularities have been recently predicted to occur in the spectral evolution of an incoherent optical wave that propagates in a noninstantaneous nonlinear medium. Here we extend this work by considering the generalized nonlinear Schrödinger equation. We show that self-steepening significantly affects these incoherent spectral singularities: (i) It leads to a delay in the development of incoherent dispersive shocks, and (ii) it arrests the incoherent collapse singularity. Furthermore, we show that the spectral collapselike behavior can be exploited to achieve a significant enhancement (by two orders of magnitudes) of…