Search results for "spheres"
showing 10 items of 329 documents
Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period
2011
Purpose: DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was todetermine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static or agitated conditions and to assess the physicochemical stability over a period of 7 days. Methods: Commercially available topotecan hydrochloride powder (Hycamtin®) was reconstituted with water for injection to yield a nominal concentration of 1 mg/mL topotecan. Polyvinyl alcohol (PVA)-based microspheres (DC Bead™, 300–500 µm, 2 mL/vial) were mixed with 4 mL of the reconstituted topotecan solution. Vials were stored light protected at room …
Loading, release and stability of epirubicin-loaded drug-eluting beads.
2015
Purpose The aim of this study was to determine the loading efficiency, physico-chemical stability and release of epirubicin-loaded DC Bead™ (Biocompatibles UK Ltd, a BTG International group company) (bead size 70–150 µm (=DC Bead M1™) and 100–300 µm) after loading with epirubicin solution (2 mg/ml) or reconstituted powder formulation (25 mg/ml) and controlled storage. Methods DC Bead™ were loaded with 76 mg epirubicin solution (Epimedac™, Medac GmbH) or 75 mg epirubicin powder formulation (Farmorubicin™, Pharmacia Pfizer GmbH) per 2 ml of beads. Drug loading efficiency and stability were determined by measuring the epirubicin concentration in the excess solution after predetermined interval…
Predictability of drug encapsulation and release from propylene carbonate/PLGA microparticles.
2020
Abstract Key parameters for microparticle-based parenteral depot formulation development are entrapment efficiency and sustained drug release, which both depend on the intermolecular affinity of the components. Here, partial solubility parameters were evaluated as descriptors for 21 drug substances and 3 polymers in propylene carbonate (PC). Out of these 21 drug substances, eight BCS class II substances (celecoxib, clotrimazole, erythromycin, ibuprofen, indomethacin, itraconazole, lopinavir and ritonavir) were encapsulated using PLGA (Poly(DL-lactide-co-glycolide)) as polymer matrix and PC as a polar aprotic solvent in order to assign microparticle properties to potential affinity-related i…
Lung tumorspheres as a drug screening platform against cancer stem cells.
2019
Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer. The main objective of this study was to characterize lung CSCs and discover new therapeutic strategies.
Inhibition of Granulocyte Function by Prednisolone and Non-Steroid Anti-Inflammatory Drugs. Quantitative Evaluation with NBT Test and its Correlation…
1980
The effect of prednisolone and non-steroid anti-inflammatory drugs on PMNL (polymorphonuclear leucocytes) oxidative metabolism was quantified with a newly standardized NBT test, and it was investigated whether these effects correlate with phagocytosing capacity of PMNL. Prednisolone inhibits NBT reduction in dose dependency already at concentrations, which do not interfere with phagocytosis. Thus prednisolone dissociates phagocytosis and phagocytosis-associated oxidative metabolism. High doses of prednisolone also inhibit phagocytosis. These effects of prednisolone are still demonstrable when PMNL are washed after pre-incubation with the drug. The non-steroid anti-inflammatory drugs (indome…
X-Raying the Dark Side of Venus - Scatter from Venus Magnetotail?
2016
This work analyzes the X-ray, EUV and UV emission apparently coming from the Earth-facing (dark) side of Venus as observed with Hinode/XRT and SDO/AIA during a transit across the solar disk occurred in 2012. We have measured significant X-Ray, EUV and UV flux from Venus dark side. As a check we have also analyzed a Mercury transit across the solar disk, observed with Hinode/XRT in 2006. We have used the latest version of the Hinode/XRT Point Spread Function (PSF) to deconvolve Venus and Mercury X-ray images, in order to remove possible instrumental scattering. Even after deconvolution, the flux from Venus shadow remains significant while in the case of Mercury it becomes negligible. Since s…
Analysis of the planetary mass uncertainties on the accuracy of atmospherical retrieval
2023
Characterising the properties of exoplanet atmospheres relies on several interconnected parameters, which makes it difficult to determine them independently. Planetary mass plays a role in determining the scale height of atmospheres, similarly to the contribution from the average molecular weight of the gas. We investigate the relevance of planetary mass knowledge in spectral retrievals, identifying cases where mass measurements are needed for clear or cloudy and primary or secondary atmospheres, along with the relevant precision, in the context of the ESA M4 Ariel Mission. We used TauREx to simulate the Ariel transmission spectra of representative targets of the Ariel mission reference sam…
Risk Assessment of a compound feed process based on HAZOP analysis and linguistic terms
2016
[EN] The size and complexity of industrial plants, along with the characteristics of the products used, require a study, analysis and control of the existing risks in every industrial process. In this paper, a methodology for risk assessment in industrial plants, based on the combination of risks identification through the Hazard and Operability (HAZOP) analysis and the risks evaluation through linguistic variables and fuzzy numbers is applied to a case study consisting on a compound feed plant located in the town of Silla (Valencia, Spain). The results from this study show that the main risk in the compound feed production process is the formation of explosive atmospheres (ATEX). Therefore…
Correcting the effect of stellar spots on ARIEL transmission spectra
2020
The goal of this study is to assess the impact of the stellar spots on the extraction of the planetary transmission spectra observed by ARIEL. We develop a method to model the stellar spectrum of a star in the presence of spots by using the out-of-transit observations. It is based on a chi squared minimization procedure of the out-of-transit spectrum on a grid of stellar spectra with different sizes and temperatures of the spots. The approach allows us also to study the temporal evolution of the spots when comparing stellar spectra observed at different epochs. We also present a method to correct the transit depth variations due to non-occulted stellar spots and estimate the error we introd…
Refined Sellmeier equations from phase-matching measurements over the complete transparency range of KTiOAsO4, RbTiOAsO4 and CsTiOAsO4
2000
Sum- and difference- frequency generation phasematching properties are measured in spheres of KTiOAsO4, RbTiOAsO4 and CsTiOAsO4 for Sellmeier equations refinement over their complete transparency range.