Search results for "stack"

showing 10 items of 392 documents

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investi…

2016

International audience; The dicarbene gold(I) complex [Au(9-methylcaffein-8-ylidene)(2)]BF4 is an exceptional organometallic compound of profound interest as a prospective anticancer agent. This gold(I) complex was previously reported to be highly cytotoxic toward various cancer cell lines invitro and behaves as a selective G-quadruplex stabilizer. Interactions of the gold complex with various telomeric DNA models have been analyzed by a combined ESI MS and X-ray diffraction (XRD) approach. ESI MS measurements confirmed formation of stable adducts between the intact gold(I) complex and Tel 23 DNA sequence. The crystal structure of the adduct formed between [Au(9-methylcaffein-8-ylidene)(2)]…

0301 basic medicineSpectrometry Mass Electrospray IonizationESI mass spectrometryStereochemistryElectrospray ionizationStackingESI mass spectrometry; G-quadruplexes; X-ray diffraction; cancer; gold[SDV.CAN]Life Sciences [q-bio]/CancerCrystal structurepotential anticancer agents010402 general chemistryG-quadruplex01 natural sciences[ CHIM ] Chemical SciencesCatalysisAdduct[ SDV.CAN ] Life Sciences [q-bio]/Cancerchemistry.chemical_compound03 medical and health sciencescancer[CHIM]Chemical SciencesChemistry010405 organic chemistryloop flexibilityapoptosiscrystal-structureGeneral ChemistryGeneral MedicineTelomeregoldG-quadruplexesinhibition3. Good health0104 chemical sciencesX-ray diffractionstabilizationcarbene complexessmall molecules030104 developmental biologypancreatic-cancer cellsX-ray crystallographySelectivityDNAmetal-complexes
researchProduct

Branch-price-and-cut algorithms for the pickup and delivery problem with time windows and multiple stacks

2016

Abstract This paper proposes models and algorithms for the pickup and delivery vehicle routing problem with time windows and multiple stacks. Each stack is rear-loaded and is operated in a last-in-first-out (LIFO) fashion, meaning that when an item is picked up, it is positioned at the rear of a stack. An item can only be delivered if it is in that position. This problem arises in the transportation of heavy or dangerous material where unnecessary handling should be avoided, such as in the transportation of cars between car dealers and the transportation of livestock from farms to slaughterhouses. To solve this problem, we propose two different branch-price-and-cut algorithms. The first sol…

050210 logistics & transportationMathematical optimization021103 operations researchInformation Systems and ManagementGeneral Computer ScienceComputer science05 social sciences0211 other engineering and technologies02 engineering and technologyManagement Science and Operations ResearchTravelling salesman problemIndustrial and Manufacturing EngineeringStack (abstract data type)Modeling and Simulation0502 economics and businessShortest path problemBenchmark (computing)Column generationPickupRouting (electronic design automation)AlgorithmEuropean Journal of Operational Research
researchProduct

Stable isotopes covering 96-7 ka BP from stalagmite CM (Santo Tomas Cave, Cuba)

2020

We present a new speleothem trace element and stable isotope record, which extends previous paleoclimate evidence from Cuban speleothems to the last 96 ka. Stable isotope samples were micromilled at a resolution of 0.10-0.33mm, and measured using an IRMS equipped with a Gasbench. Line scans of Element/Calcium ratios of the speleothem were measured by laser ablation ICPMS and were reduced to the resolution of the stable isotope records.

AGESpeleothem sampleδ13C stackedδ13CEarth System Researchpaleoclimatologyδ18O stackedstackedCentral Americaδ18OMass spectrometer DeltaPlusXL coupled to a Gasbench IIspeleothemStable isotopes
researchProduct

Ethical Requirements Stack : A framework for implementing ethical requirements of AI in software engineering practices

2023

AI ethicsAIAI ethics principlesEthical requirementsEthical requirements stackAgile portfolio managementetiikkatekoäly
researchProduct

On the selection of AGN neutrino source candidates for a source stacking analysis with neutrino telescopes

2006

The sensitivity of a search for sources of TeV neutrinos can be improved by grouping potential sources together into generic classes in a procedure that is known as source stacking. In this paper, we define catalogs of Active Galactic Nuclei (AGN) and use them to perform a source stacking analysis. The grouping of AGN into classes is done in two steps: first, AGN classes are defined, then, sources to be stacked are selected assuming that a potential neutrino flux is linearly correlated with the photon luminosity in a certain energy band (radio, IR, optical, keV, GeV, TeV). Lacking any secure detailed knowledge on neutrino production in AGN, this correlation is motivated by hadronic AGN mode…

AMANDAActive galactic nucleusAstrophysics::High Energy Astrophysical PhenomenaFOS: Physical sciencesCosmic rayAstrophysicsAstrophysics::Cosmology and Extragalactic AstrophysicsAstrophysicsIceCubeLuminosityAGNNeutrinosBlazarAstrophysics::Galaxy AstrophysicsAGN; AMANDA; IceCube; Neutrinos; Point sources; Source stackingAstroparticle physicsPhysicsAstrophysics (astro-ph)Point sourcesAstronomyAstronomy and AstrophysicsQuasarSource stackingNeutrino detectorAstronomiaHigh Energy Physics::ExperimentNeutrino
researchProduct

Crystallographic and (spectro)electrochemical characterizations of cobalt(II) 10-phenyl-5,15-di-p-tolylporphyrin

2021

International audience; The synthesis, cyclic and rotating disk electrode voltammograms, UV-visible absorption and Xray diffraction analyses of cobalt(II) 10-phenyl-5,15-dip -tolylporphyrin (1-Co) are described. 1-Co was crystallized by slow diffusion of n-hexane into a concentrated CH2Cl2 solution. X-ray diffraction analyses reveals porphyrin aromatic cycle stacking in the crystal, C-H•••π interactions of the CH2Cl2 solvent with the π-system of one tolyl group and Co(II)•••π (porphyrin ring) interactions. The abstraction of 1.0 F/mol during the electrolysis at the first oxidation potential was followed by spectroelectrochemistry. It leads to the Co(II) → Co(III) transformation rather than …

Absorption spectroscopyStackingchemistry.chemical_elementCo(II)•••pi interactions010402 general chemistryElectrochemistryElectrosynthesis01 natural sciencesAnalytical Chemistrylaw.inventionInorganic ChemistryPorphyrinchemistry.chemical_compoundlaw[CHIM.ANAL]Chemical Sciences/Analytical chemistry[CHIM.COOR]Chemical Sciences/Coordination chemistryRotating disk electrodeSpectroscopyX-ray crystallographic structureElectrolysis010405 organic chemistry[CHIM.ORGA]Chemical Sciences/Organic chemistryOrganic ChemistryCobalt[CHIM.MATE]Chemical Sciences/Material chemistryPorphyrin0104 chemical sciencesCrystallographychemistrystacked aromatics dimersElectrosynthesisC-H•••pi interactionsCobalt
researchProduct

Neuromuscular responses to different resistance loading protocols using pneumatic and weight stack devices

2013

The purpose of this study was to examine single repetition characteristics and acute neuromuscular responses to typical hypertrophic (HL), maximal strength (MSL), and power (PL) loadings performed with two of the most common resistance modes; pneumatic and weight stack. Acute responses were assessed by measuring maximal voluntary contraction (MVC), corresponding quadriceps-EMG and resting and superimposed twitch torques. Activation level was calculated from the twitch torques. Decreases in MVC were greater during HL and MSL than during PL. During HL, resting twitch force decreased 8% (P < 0.05) more on the weight stack than on the pneumatic device. Furthermore, loading using the weight stac…

AdultMaleMaterials sciencePhysical ExertionBiophysicsNeuroscience (miscellaneous)Young AdultVoluntary contractionStack (abstract data type)Maximal strengthmedicineHumansContraction velocityTwitch forceMuscle SkeletalMuscle fatigueResistance trainingResistance TrainingTorquePhysical FitnessMuscle FatiguePhysical EnduranceNeurology (clinical)medicine.symptomMuscle ContractionBiomedical engineeringMuscle contractionJournal of Electromyography and Kinesiology
researchProduct

A Novel Deep Learning Stack for APT Detection

2019

We present a novel Deep Learning (DL) stack for detecting Advanced Persistent threat (APT) attacks. This model is based on a theoretical approach where an APT is observed as a multi-vector multi-stage attack with a continuous strategic campaign. To capture these attacks, the entire network flow and particularly raw data must be used as an input for the detection process. By combining different types of tailored DL-methods, it is possible to capture certain types of anomalies and behaviour. Our method essentially breaks down a bigger problem into smaller tasks, tries to solve these sequentially and finally returns a conclusive result. This concept paper outlines, for example, the problems an…

Advanced persistent threatProcess (engineering)Computer science020209 energyDistributed computing02 engineering and technologylcsh:Technologylcsh:ChemistryStack (abstract data type)020204 information systemsAdvanced Persistent Thread (APT)0202 electrical engineering electronic engineering information engineeringGeneral Materials Sciencetietoturvalcsh:QH301-705.5Instrumentationta113Fluid Flow and Transfer Processeslcsh:Tbusiness.industryProcess Chemistry and TechnologyDeep learningGeneral EngineeringFlow networklcsh:QC1-999Computer Science Applicationsnetwork anomaly detectionkoneoppiminenlcsh:Biology (General)lcsh:QD1-999lcsh:TA1-2040Deep Learning (DL)Artificial intelligencelcsh:Engineering (General). Civil engineering (General)Raw databusinessverkkohyökkäyksetlcsh:Physics
researchProduct

Computational Analysis of the Active Control of Incompressible Airfoil Flutter Vibration Using a Piezoelectric V-Stack Actuator

2021

The flutter phenomenon is a potentially destructive aeroelastic vibration studied for the design of aircraft structures as it limits the flight envelope of the aircraft. The aim of this work is to propose a heuristic design of a piezoelectric actuator-based controller for flutter vibration suppression in order to extend the allowable speed range of the structure. Based on the numerical model of a three degrees of freedom (3DOF) airfoil and taking into account the FEM model of a V-stack piezoelectric actuator, a filtered PID controller is tuned using the population decline swarm optimizer PDSO algorithm, and gain scheduling (GS) of the controller parameters is used to make the control adapti…

Airfoil020301 aerospace & aeronautics0209 industrial biotechnologyactive flutter suppressionV-stack actuatorComputer sciencePID controller02 engineering and technologylcsh:QC1-999Vibrationpopulation decline swarmoptimizer020901 industrial engineering & automationGain scheduling0203 mechanical engineeringFlight envelopeControl theoryFluttergain schedulingpopulation decline swarm optimizerSettore ING-IND/04 - Costruzioni E Strutture AerospazialiActuatorlcsh:PhysicsVibration
researchProduct

Complex multiplication, Griffiths-Yukawa couplings, and rigidity for families of hypersurfaces

2003

Let M(d,n) be the moduli stack of hypersurfaces of degree d &gt; n in the complex projective n-space, and let M(d,n;1) be the sub-stack, parameterizing hypersurfaces obtained as a d fold cyclic covering of the projective n-1 space, ramified over a hypersurface of degree d. Iterating this construction, one obtains M(d,n;r). We show that M(d,n;1) is rigid in M(d,n), although the Griffiths-Yukawa coupling degenerates for d&lt;2n. On the other hand, for all d&gt;n the sub-stack M(d,n;2) deforms. We calculate the exact length of the Griffiths-Yukawa coupling over M(d,n;r), and we construct a 4-dimensional family of quintic hypersurfaces, and a dense set of points in the base, where the fibres ha…

Algebra and Number TheoryDegree (graph theory)Mathematics - Complex Variables14D0514J3214D07Complex multiplicationYukawa potentialRigidity (psychology)14J70ModuliCombinatoricsAlgebraMathematics - Algebraic Geometry14J70; 14D05; 14D07; 14J32HypersurfaceMathematics::Algebraic GeometryMathematikFOS: MathematicsGeometry and TopologyComplex Variables (math.CV)Algebraic Geometry (math.AG)Stack (mathematics)Mathematics
researchProduct