Search results for "start"

Supporting start-up business model design through system dynamics modelling

2017

Purpose The purpose of this paper is to explore how system dynamics (SD) modelling can provide a methodological support to business model (BM) design with the intent to better communicate business strategy and manage performance. Design/methodology/approach After a literature review of the field and an analysis of the strengths and limitations of conventional BM frameworks, the paper illustrates and discusses an approach that combines such a framework with SD modelling. A single-case study design was selected to explore the implications and limitations of using this combined approach to business modelling. Findings The methodological support provided by SD to BM design may effectively impr…

Suppliers’ software development project start-up practices

2017

Purpose The purpose of this paper is to present a life cycle phase of a software development project which is substantial for the success of the project. This paper visualizes the project start-up phase from suppliers’ perspective. Design/methodology/approach The method is a theory building from case studies. The data were collected from three software supplier firms by conducting process modeling separately in each firm. Findings The study resulted in a model of a supplier’s software project start-up which includes start-up practices and involved roles. The results indicate that project start-up is an integral and structured phase of project life cycle, which influences the execution of a…

The Influence of Entrepreneurial Learning in New Firms’ Performance: A Study in Costa Rica

2014

The creation of new firms is important for the economy, and entrepreneurial learning is essential for the performance of new firms. We contribute to existing knowledge by combining these two topics and considering a third one: The role of multinational companies (MNCs) as a source of learning for the entrepreneur. This approach has rarely been taken in the literature. We investigated the performance of a group of young companies created by former employees of MNCs and their relationship with entrepreneurial learning in such companies. The study was based on a sample of 175 former employees of MNCs in Costa Rica, who founded their own firm between 2001 and 2007. The control group was formed …

Use of selected autochthonous lactic acid bacteria for Spanish-style table olive fermentation

2012

The present work presents a successful attempt to achieve an enhanced and more predictable fermentation process in Spanish-style green olive technology by selection and use of autochthonous starter cultures. During the first phase of this work, two Spanish-like fermentations of green table olives of cultivar (cv) “Nocellara del Belice”, coming from irrigated and not irrigated fields, were monitored, in order to highlight the best agricultural conditions for drupe production and to isolate lactic acid bacteria strains with relevant technological properties. Among 88 identified isolates, one Lactobacillus pentosus strain showed remarkable biochemical features and high acidification rate in sy…

FEDRO: a software tool for the automatic discovery of candidate ORFs in plants with c →u RNA editing

2019

RNA editing is an important mechanism for gene expression in plants organelles. It alters the direct transfer of genetic information from DNA to proteins, due to the introduction of differences between RNAs and the corresponding coding DNA sequences. Software tools successful for the search of genes in other organisms not always are able to correctly perform this task in plants organellar genomes. Moreover, the available software tools predicting RNA editing events utilise algorithms that do not account for events which may generate a novel start codon. We present Fedro, a Java software tool implementing a novel strategy to generate candidate Open Reading Frames (ORFs) resulting from Cytidi…

Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation

2020

The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the long-term consequences of early s…

L’art. 39-septies del Decreto “Semplificazioni” 2021 in tema di S.R.L. Start up innovative costituite in forma telematica

2021

Nel ripercorrere le tappe del travagliato iter normativo e giurisprudenziale che ha interessato la genesi telematica della S.r.l. Start up innovative, lo studio si focalizza sul tema della sanatoria degli atti costitutivi in forma telematica, evidenziando possibili criticità della soluzione adottata.

I reattori aerobici granulari: esperienze con refluo reale e sintetico

2008

La granulazione aerobica può essere ottenuta nei sistemi con alimentazione discontinua in due differenti configurazioni impiantistiche, che permettono di realizzare i necessari sforzi tangenziali per la formazione dei granuli: il Sequencing Batch Bubble Column Reactor (SBBC) e il Sequencing Batch Airlift Reactor (SBAR). Lo scopo di questo studio è stato quello di osservare il fenomeno della granulazione aerobica e valutare il ruolo del tempo di sedimentazione durante la fase di selezione e formazione dei granuli. L’intera sperimentazione è stata suddivisa in due diverse campagne sperimentali in cui è stato utilizzato refluo sintetico, nella prima, e refluo reale, nella seconda. Al fine di e…

Perception of body self of children suffering from chronic heart disease and parent coping strategy

2009

The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress

2020

ABSTRACT Start is the main decision point in the eukaryotic cell cycle at which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional programme through the inactivation of Start transcriptional repressors: the retinoblastoma family in mammals, or Whi5 and its recently identified paralogue Whi7 (also known as Srl3) in budding yeast. Here, we provide a comprehensive comparison of Whi5 and Whi7 that reveals significant qualitative differences. Indeed, the expression, subcellular localization and functionality of Whi7 and Whi5 are differentially regulated. Importantly, Whi7 shows specific properties in its association with promoters not share…