Search results for "state"
showing 10 items of 9165 documents
Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers
2016
A new series of pyrrolo[3′,2′:6,7]cyclohepta[1,2-d]pyrimidin-2-amines, was conveniently prepared using a versatile and high yielding multistep sequence. A good number of derivatives was obtained and the cellular photocytotoxicity was evaluated in vitro against three different human tumor cell lines with EC50 (0.08–4.96 μM) values reaching the nanomolar level. Selected compounds were investigated by laser flash photolysis. The most photocytotoxic derivative, exhibiting a fairly long-lived triplet state (τ ∼ 7 μs) and absorbance in the UV–Vis, was tested in the photo-oxidations of 9,10-anthracenedipropionic acid (ADPA) by singlet oxygen. The photosentizing properties are responsible for the c…
A Standardized Wedelia chinensis Extract Overcomes the Feedback Activation of HER2/3 Signaling upon Androgen-Ablation in Prostate Cancer
2017
Crosstalk between the androgen receptor (AR) and other signaling pathways in prostate cancer (PCa) severely affects the therapeutic outcome of hormonal therapy. Although anti-androgen therapy prolongs overall survival in PCa patients, resistance rapidly develops and is often associated with increased AR expression and upregulation of the HER2/3-AKT signaling pathway. However, single agent therapy targeting AR, HER2/3 or AKT usually fails due to the reciprocal feedback loop. Previously, we reported that wedelolactone, apigenin, and luteolin are the active compounds in Wedelia chinensis herbal extract, and act synergistically to inhibit the AR activity in PCa. Here, we further demonstrated th…
Hybrid State Feedback Position-Force Control of Hydraulic Cylinder
2019
A hybrid position-force control is proposed using a unified state feedback controller in combination with feedforward dead-zone compensation. Dead-zone compensator was constructed as inverse of the identified static map while the state feedback gains were obtained using a numerical optimization routine. An accurate state-space model affine in states and control, derived in a previous work, was used for closed-loop simulations and control tuning. A trigger event for automatic switching between position and force control was defined and integrated into overall control architecture alongside with a feedforward low-pass filter reducing high frequency components in the control signal. Experiment…
Reduced firing rates of pyramidal cells in frontal cortex of APP/PS1 can be restored by acute treatment with levetiracetam
2019
AbstractIn recent years aberrant neural oscillations in various cortical areas have emerged as a common physiological hallmark across mouse models of amyloid pathology and patients with Alzheimer’s disease. However, much less is known about the underlying effect of amyloid pathology on single cell activity. Here, we used high density silicon probe recordings from frontal cortex area of 9 months old APP/PS1 mice to show that resting state Local Field Potential (LFP) power in the theta and beta band is increased in transgenic animals, while single cell firing rates, specifically of putative pyramidal cells, are significantly reduced. At the same time, these sparsely firing pyramidal cells pha…
Long-term home-based physiotherapy for persons with signs of frailty–RCT (NCT02305433)
2018
Introduction/Background Frailty is a multidimensional condition, which can lead to disability. To postpone long-term care, one alternative is home-based physiotherapy. We study the effects of a 12-month home-based physiotherapy program on functional capacity, and applying successive 12-month register follow-up, on the use and costs of social and health care services, and on the duration of living at home during 24 months (the primary outcome). Here we report about feasibility of the intervention and baseline characteristics. Material and method Three hundred home-dwelling persons (>65 y) with signs of frailty were recruited by September, 2016. Frailty was screened by Morley's FRAIL question…
The Current State of Knowledge on the Clinical and Methodological Aspects of Extracorporeal Shock Waves Therapy in the Management of Post-Stroke Spas…
2021
In many patients after stroke, spasticity develops over time, resulting in a decrease in the patient’s independence, pain, worsening mood, and, consequently, lower quality of life. In the last ten years, a rich arsenal of physical agents to reduce muscle tone such as extracorporeal shock therapy (ESWT) wave has come through. The aim of this narrative review article is to present the current state of knowledge on the use of ESWT as a supplement to the comprehensive rehabilitation of people after stroke suffering from spasticity. The PubMed and PEDro databases were searched for papers published in English from January 2000 to December 2020, 22 of which met inclusion criteria for clinical stud…
Two Approaches to Examine the Impact of Different Credit Default Indicators on Real Estate Loans
2019
Abstract Financing of real estates was a trigger of the largest financial crisis after the “Great Depression” from the early thirties in the last century. One of the main causes of this 2007 crisis was poor risk management in real estate financing. The aim of this paper is to examine the impact of different classes of indicators on credit default rates of real estate loans. Two research approaches should confirm a model that proves how strong the relationship is between different predictor variables such as interest rates, macroeconomic and individual indicators on the response variable of credit defaults. The first approach focuses on conducting descriptive and inferential experimental res…
Evaluating a hierarchical approach to landscape-level harvest scheduling
2018
Forest planning at the landscape level has the potential to become a large intractable problem. In Finland, Metsähallitus (the state enterprise that manages federally owned land) creates strategic plans to determine the appropriate harvest level. While these plans are feasible, they are not implementable in practice as the harvests are scattered temporally and spatially. Requiring that harvests be organized both temporally and spatially for practical implementation can result in an intractable problem. Through a hierarchical approach, the problem can be organized into steps in which the intractable problem is broken down into smaller easily solvable parts. As an approximation technique, th…
The language of recovery
2020
Abstract The present study attempts to make a comparative analysis of two Spanish and American political speeches, which belong to two different debate traditions, in terms of the metaphors used. For that purpose, we analyze the Economy sections of the 2015 State of the Union Address in the US and in the 2015 State of the Nation Debate in Spain. The present study aims at answering the following research questions: What metaphors do President Obama and Prime Minister Rajoy use in the American and Spanish political speeches to convince their audiences of America’s and Spain’s economic victory? What are the similarities and differences between the representations depicted by metaphor use in th…
Eventual Consistency Formalized
2019
Distribution of computation is well-known, and there are several frameworks, including some formal frameworks, that capture distributed computation. As yet, however, models of distributed computation are based on the idea that data is conceptually centralized. That is, they assume that data, even if it is distributed, is consistent. This assumption is not valid for many of the database systems in use today, where consistency is compromised to ensure availability and partition tolerance. Starting with an informal definition of eventual consistency, this paper explores several measures of inconsistency that quantify how far from consistency a system is. These measures capture key aspects of e…