Search results for "statement"
showing 10 items of 185 documents
Reply from m. Heino, j.a.j. Metz and v. Kaitala.
1998
Eva Kisdi clarifies the relationships between frequency dependence, optimization and ESSs. We basically agree with all her comments. However, some further clarification may be useful.In the first paragraph of Kisdi's letter, ESSs and optimal strategies are seemingly opposed by saying that `finding an optimal strategy is a considerably stronger result than finding an ESS'. Although this statement is factually correct, it might engender a suggestion that is slightly wrong. Conceptually, ESSs are always primary: only ESSs matter from the viewpoint of long-term evolution. Optimization is secondary only, and must be justified by an ESS argument that explicitly accounts for the ecology in which t…
Physical Activity and Nutrition INfluences In ageing (PANINI): consortium mission statement
2018
First paragraph: Current demographic trends indicate that by the year 2020, almost one in five of the European population will be aged 65 years or over. Although life expectancy is increasing by 2 years per decade, the period of life spent in good health is not keeping pace and most Europeans spend their last decade in poor health. Consequently, there is an urgent need to understand how lifestyle factors can influence age-related changes from gene to society level and how they may be integrated into a net effect of healthy ageing. It is also crucial to develop and validate interventions and health policies to ensure that more of our older adults have a healthy and active later life. This is…
Neoadjuvant Management of Early Breast Cancer: A Clinical and Investigational Position Statement
2019
AbstractBackgroundNeoadjuvant treatment is increasingly one of the preferred therapeutic options for early breast cancer and may have some unique outcomes, such as identifying predictive and prognostic factors of response or increasing the knowledge of individual tumor biology.DesignA panel of experts from different specialties reviewed published clinical studies on the neoadjuvant management of breast cancer. Recommendations were made that emphasized the clinical multidisciplinary management and the investigational leverage in early breast cancer.ResultsNeoadjuvant therapy has equivalent efficacy to adjuvant therapy, and it has some additional benefits that include increasing breast conser…
Genetic Testing for Melanoma—Where Are We With Moderate-Penetrance Genes?
2016
International audience
Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
2020
Summary The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been implicated in reward seeking. However, the precise molecular and physiological basis of reward-seeking behavior remains unknown. We found that the specific deletion of metabotropic glutamate receptor 5 (mGluR5) in D1-expressing MSNs (D1miRmGluR5 mice) abolishes eCB-mediated long-term depression (LTD) and prevents the expression of drug (cocaine and ethanol), natural reward (saccharin), and brain-stimulation-seeking behavior. In vivo enhancement…
Administrative Coding in Electronic Health Care Record‐Based Research of NAFLD: An Expert Panel Consensus Statement
2021
BACKGROUND AND AIMS: Electronic health record (EHR)-based research allows the capture of large amounts of data, which is necessary in nonalcoholic fatty liver disease (NAFLD), where the risk of clinical liver outcomes is generally low. The lack of consensus on which International Classification of Disease (ICD) codes should be used as exposures and outcomes limits comparability and generalizability of results across studies. We aimed to establish consensus among a panel of experts on ICD codes that could become the reference standard and provide guidance around common methodological issues.APPROACH AND RESULTS: Researchers with an interest in EHR-based NAFLD research were invited to collect…
Consensus statement on the problem of terminology in psychological interventions using the internet or digital components
2020
Since the emergence of psychological interventions delivered via the Internet they have differed in numerous ways. The wealth of formats, methods, and technological solutions has led to increased availability and cost-effectiveness of clinical care, however, it has simultaneously generated a multitude of terms. With this paper, we first aim to establish whether a terminology issue exists in the field of Internet-delivered psychological interventions. If so, we aim to determine its implications for research, education, and practice. Furthermore, we intend to discuss solutions to mitigate the problem; in particular, we propose the concept of a common glossary. We invited 23 experts in the fie…
Four Potential Meanings of Double Negation
2016
The figurative use of double negations (not uninteresting, not unhappy) has been described by linguists and rhetoricians with regards to the rhetorical figure litotes. Both mitigation and strengthening have been proposed as aims of litotes (Horn, 1989; Krifka, 2007; van der Wouden, 1996). An analysis of the construction nicht un-adjective (not un-adj.) on the basis of German corpora leads to a coherent system of pragmatic functions for this sort of double negations. The construction can function as denial, potential presumption denial, mitigation or understatement. Nevertheless, litotes exemplifies the “indeterminate nature of figurative meaning” as suggested by Colston/Gibbs (2012: 259) in…
On the relation of irony, understatement, and litotes
2016
The aim of this paper is to clarify the distinctive and the shared features of the three phenomena: irony, understatement, and litotes. These rhetorical figures have been defined as synonymous, distinct or overlapping in various accounts. This indicates an interrelation but also a need for clearer definitions. Here, each of these rhetorical figures is defined via two jointly necessary conditions. This approach sharpens the categories, enables clear-cut distinctions and helps to explain cases of overlap. German corpus data and examples from the literature as a basis, allow differentiating between cases of understatement as a means of irony, and cases of litotes as a means of understatement. …
Indexing epistemic incongruence: uy as a formal sign of disagreement in agreement sequences in Spanish
2018
Abstract This study explores epistemic incongruence in Spanish by focusing on the particle uy in Iberian Spanish. It is claimed that this interjection has a basic change-of-state meaning and that it is commonly used to stress disagreement. Despite its general association to disagreement, the particle can be used in agreeing responses, where it also treats the previous turn as problematic. In this sequential environment, however, it is not the content of the previous turn but rather the underlying assumptions (the basic epistemic configuration of an assertion-answer adjacency pair) that are challenged by the second speaker. The evidence for this analysis comes from the sequential context. Ty…