Search results for "statistical"
showing 10 items of 4960 documents
Statistical shape analysis of ascending thoracic aortic aneurysm: Correlation between shape and biomechanical descriptors
2020
An ascending thoracic aortic aneurysm (ATAA) is a heterogeneous disease showing different patterns of aortic dilatation and valve morphologies, each with distinct clinical course. This study aimed to explore the aortic morphology and the associations between shape and function in a population of ATAA, while further assessing novel risk models of aortic surgery not based on aortic size. Shape variability of n = 106 patients with ATAA and different valve morphologies (i.e., bicuspid versus tricuspid aortic valve) was estimated by statistical shape analysis (SSA) to compute a mean aortic shape and its deformation. Once the computational atlas was built, principal component analysis (PCA) allow…
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Energy dissipative solutions to the Kobayashi-Warren-Carter system
2017
In this paper we study a variational system of two parabolic PDEs, called the Kobayashi-Warren-Carter system, which models the grain boundary motion in a polycrystal. The focus of the study is the existence of solutions to this system which dissipate the associated energy functional. We obtain existence of this type of solutions via a suitable approximation of the energy functional with Laplacians and an extra regularization of the weighted total variation term of the energy. As a byproduct of this result, we also prove some $\Gamma$-convergence results concerning weighted total variations and the corresponding time-dependent cases. Finally, the regularity obtained for the solutions togethe…
Nonradial normalized solutions for nonlinear scalar field equations
2018
We study the following nonlinear scalar field equation $$ -\Delta u=f(u)-\mu u, \quad u \in H^1(\mathbb{R}^N) \quad \text{with} \quad \|u\|^2_{L^2(\mathbb{R}^N)}=m. $$ Here $f\in C(\mathbb{R},\mathbb{R})$, $m>0$ is a given constant and $\mu\in\mathbb{R}$ is a Lagrange multiplier. In a mass subcritical case but under general assumptions on the nonlinearity $f$, we show the existence of one nonradial solution for any $N\geq4$, and obtain multiple (sometimes infinitely many) nonradial solutions when $N=4$ or $N\geq6$. In particular, all these solutions are sign-changing.
Porosities and dimensions of measures
1999
We introduce a concept of porosity for measures and study relations between dimensions and porosities for two classes of measures: measures on $R^n$ which satisfy the doubling condition and strongly porous measures on $R$.
Testing mode-coupling theory for a supercooled binary Lennard-Jones mixture
1995
Abstract We have performed a molecular dynamics computer simulation study to investigate the dynamical behavior of a supercooled simple liquid for comparison with the predictions of mode-coupling theory (MCT). By scaling the intermediate scattering function by the α-relaxation time r we find that the correlators fall onto a master curve extending over several decades in time. Thus we find that the time temperature superposition principle holds. In the late β-relaxation regime this master curve can be fitted very well by a master curve predicted by the idealized version MCT. However, there is no evidence for the presence of the critical decay predicted by the theory for the early part of the…
Bifurcations of links of periodic orbits in non-singular Morse - Smale systems on
1997
The set of periodic orbits of a non-singular Morse - Smale (NMS) flow on defines a link; a characterization of all possible links of NMS flows on has been developed by Wada. In the frame of codimension-one bifurcations, this characterization allows us to study the restrictions a link requires for suffering a given bifurcation. We also derive the topological description of the new link and the possibility of relating links by a chain of this type of bifurcation.
Visible parts and dimensions
2003
We study the visible parts of subsets of n-dimensional Euclidean space: a point a of a compact set A is visible from an affine subspace K of n, if the line segment joining PK(a) to a only intersects A at a (here PK denotes projection onto K). The set of all such points visible from a given subspace K is called the visible part of A from K. We prove that if the Hausdorff dimension of a compact set is at most n−1, then the Hausdorff dimension of a visible part is almost surely equal to the Hausdorff dimension of the set. On the other hand, provided that the set has Hausdorff dimension larger than n−1, we have the almost sure lower bound n−1 for the Hausdorff dimensions of visible parts. We al…
One-dimensional families of projections
2008
Let m and n be integers with 0 < m < n. We consider the question of how much the Hausdorff dimension of a measure may decrease under typical orthogonal projections from onto m-planes provided that the dimension of the parameter space is one. We verify the best possible lower bound for the dimension drop and illustrate the sharpness of our results by examples. The question stems naturally from the study of measures which are invariant under the geodesic flow.
Comparison of discretization strategies for the model-free information-theoretic assessment of short-term physiological interactions
2023
This work presents a comparison between different approaches for the model-free estimation of information-theoretic measures of the dynamic coupling between short realizations of random processes. The measures considered are the mutual information rate (MIR) between two random processes [Formula: see text] and [Formula: see text] and the terms of its decomposition evidencing either the individual entropy rates of [Formula: see text] and [Formula: see text] and their joint entropy rate, or the transfer entropies from [Formula: see text] to [Formula: see text] and from [Formula: see text] to [Formula: see text] and the instantaneous information shared by [Formula: see text] and [Formula: see…