Search results for "stil"
showing 10 items of 1452 documents
Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
2012
Resveratrol (RSV), a plant-derived stilbene, induces cell death in Hodgkin lymphoma (HL)-derived L-428 cells in a dose-dependent manner (IC50 = 27 μM, trypan blue exclusion assay). At a lower range (25 μM), RSV treatment for 48 hr causes arrest in the S-phase of the cell cycle, while at a higher concentration range (50 μM), apoptosis can be detected, with activation of caspase-3. The histone/protein deacetylase SIRT1 has been described as a putative target of RSV action in other model systems, even though its role in cancer cells is still controversial. Here we show that RSV, at both concentration ranges, leads to a marked increase in p53, while a decrease of SIRT1 expression level, as well…
Abstract 1280: Pterostilbene exerts full protection against UVB-induced skin carcinogenesis.
2013
Abstract Epidemiological, clinical and laboratory studies have demonstrated that solar ultraviolet (UV) radiation is the main cause of nonmelanoma skin cancer (i.e., basal cell and squamous cell carcinoma) and it is also a prime factor in the etiology of cutaneous melanoma. The cancer-causing effects of solar exposure on the skin are mainly produced by UV-B radiation in the 290- to 320-nm range, the same range that produces burning in human skin (erythema), inflammation, oxidative stress, DNA damage, etc. Thus, and considering the alarming numbers of skin cancers being diagnosed around the world, it is increasingly evident the need of an effective protection against UV radiation. Polyphenol…
Abstract 4239: Pterostilbene, a natural polyphenol, elicits full protection against ultraviolet B radiation-induced skin carcinogenesis: Preclinical …
2011
Abstract Solar radiation exposure is the chief cause of nonmelanoma (i e, basal cell and squamous cell) skin cancer, and it is also a prime factor in the etiology of cutaneous melanoma The cancer-causing effects of ultraviolet (UV) radiation on the skin are mainly produced by UV-B radiation in the 290- to 320-nm range, the same range that produces burning in human skin (erythema) UV-B exposure can damage DNA and be immunosuppressive Thus, and considering the alarming numbers of skin cancers being diagnosed around the world, it is increasingly evident the need of effective protection from UV radiation Resveratrol (trans-3,5,4′-trihydroxystilbene; RES) is a phytoalexin present in a wide varie…
Cardiovascular effects and molecular targets of resveratrol
2012
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenol phytoalexin present in a variety of plant species and has been implicated to explain the health benefits of red wine. A wide range of health beneficial effects have been demonstrated for resveratrol in animal studies. In this review, we summarize the cardiovascular effects of resveratrol with emphasis on the molecular targets of the compound. In this regard, resveratrol stimulates endothelial production of nitric oxide, reduces oxidative stress, inhibits vascular inflammation and prevents platelet aggregation. In animal models of cardiovascular disease, resveratrol protects the heart from ischemia-reperfusion injury, reduces blo…
Association between Pterostilbene and Quercetin Inhibits Metastatic Activity of B16 Melanoma
2005
AbstractInhibition of cancer growth by resveratrol (trans-3,5,4'trihydroxystilbene; RESV), a phytoalexin present in many plant species, is limited by its low bioavailability. Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene; PTER) and quercetin (3,3',4',5,6-pentahydroxyflavone; QUER), two structurally related and naturally occurring small polyphenols, show longer half-life in vivo. In vitro growth of highly malignant B16 melanoma F10 cells (B16M-F10) is inhibited (56%) by short-time exposure (60 min/day) to PTER (40 μM) and QUER (20 μM) (approximate mean values of plasma concentrations measured within the first hour after intravenous administration of 20 mg/kg of each polyphenol). Intravenou…
Lajiristeyksiä maan ääressä : lajityyppien intertekstuaalinen analyysi Kristina Carlsonin romaanista Maan ääreen
2014
Pro gradu -tutkielmani aineena on lajityyppien intertekstuaalinen analyysi Kristina Carlsonin romaanista Maan ääreen (1999). Tarkastelen romaania ja siitä kirjoitettua kymmentä kirjallisuusarvostelua, joiden mukaan teoksesta on löydettävissä useita eri genrejä. Selvitän, ilmenevätkö kirjallisuusarvosteluissa esitetyt lajit Maan ääreen -romaanissa, ja jos ilmenevät, niin millä tavoin. Tutkin myös minkälaista lisätietoa romaanin lajipiirteiden tarkastelu tuotaa teoksesta ja siitä kirjoitetuista kirjallisuusarvosteluista. Tarkastelen Maan ääreen -romaanin lajeja intertekstuaalisuuden näkökulmasta. Laajassa kontekstissa intertekstuaalisuus ilmenee muun muassa lajien välisenä kommunikaationa, jo…
Algunas reflexiones acerca de la stjue de 9 de julio de 2020 sobre los pactos novatorios en materia de cláusulas suelo
2021
The Sentence of the Court of Justice of the European Union of July 9, 2020 comes to answer the five questions that, in its preliminary question, the Court of First Instance and Instruction No. 3 of Teruel asks about the validity of the new agreements in the context of the floor clauses, establishing jurisprudential doctrine on this matter about which our Supreme Court had previously ruled in its Judgments of October 16, 2017, in the sense of considering the agreed floor clause null as a consequence of the novation agreement and, subsequently, those of April 11, 2018 and September 13, 2018 in the opposite direction, declaring that the novation agreement was valid. It is a long-awaited and in…
Los ballesteros del rey, los arneses empeñados y otros nuevos documentos sobre Pero Niño
2018
RESUMENSe presentan cuatro documentos hasta ahora desconocidos sobre Pero Niño, datados entre 1404 y 1431, que arrojan luz sobre algunos episodios poco detallados o silenciados en El Victorial, la biografía caballeresca que le dedicó Gutierre Díaz de Games.PALABRAS CLAVEPero Niño, Gutierre Díaz de Games, El Victorial.ABSTRACTThis study presents four unknown documents about Pero Niño, dated between 1404 and 1431. They shed light on several episodes that are undetailed or silenced in El Victorial, the chivalric biography written by Gutierre Díaz de Games.KEYWORDSPero Niño, Gutierre Díaz de Games, El Victorial.
[Carta del Director de l'Associación Valenciana de Caridad, D. José Vilar-Sancho, al Rector de la Universidad de Valencia, comunicant-li que obren en…
Mecanografiat Títol donat pel catalogador
Una Carta Puebla inédita: la capitulación de los moros de Serra de 1365
1999
La principal aportación del presente artículo es la difusión de una carta de capitulación que hasta la fecha permanecía inédita. Gracias a ésta podemos vislumbrar el papel jugado por los moros de Serra y de otros lugares de la Sierra Calderona en la guerra contra Castilla.