Search results for "stressi"
showing 10 items of 285 documents
Elevated oxidative stress in pied flycatcher nestlings of eumelanic foster fathers under low rearing temperatures
2019
Striking variation in melanin coloration within natural populations is likely due to the different fitness outcomes of alternative phenotypes in varying environmental conditions. There are two types of melanin: eumelanins yield blackish hues, whereas pheomelanins yield reddish hues. The production of eumelanins requires low levels of glutathione (GSH), which is the most important intracellular antioxidant, whereas the production of pheomelanins requires high levels of GSH. We investigated the oxidative status of male pied flycatchers (Ficedula hypoleuca) with different degrees of melanin coloration under different temperatures during the nestling period. Moreover, we assessed the oxidative …
Direct and transgenerational effects of an experimental heatwave on early life stages in a freshwater snail
2019
1. Global climate change imposes a serious threat to natural populations of many species. Estimates of the effects of climate change‐mediated environmental stresses are, however, often based only on their direct effects on organisms, and neglect the potential transgenerational (e.g. maternal) effects. 2. We tested whether high temperature (i.e. an experimental heatwave), which is known to reduce the performance of adult Lymnaea stagnalis snails, affects the produced offspring (eggs and hatchlings) through maternal effects, and how strong these effects are compared with the effects of direct exposure of offspring to high temperature. We examined the effect of maternal thermal environment (15…
Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins
2016
Aim Sirtuins are proteins that connect energy metabolism, oxidative stress and aging. Expression of heat shock proteins (Hsps) is regulated by heat shock factors (HSFs) in response to various environmental and physiological stresses, such as oxidative stress. Oxidative stress accumulates during aging which makes cells more prone to DNA damage. Although many experimental animal models have been designed to study the effects of knockdown or overexpression of sirtuins, HSFs and Hsps, little is known about how aging per se affects their expression. Here we study the impact of intrinsic aerobic capacity, aging and voluntary exercise on the levels of sirtuins, HSFs and Hsps in skeletal muscle. Me…
Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver
2019
Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated the acute (1–2 days) and 2-week effects of blocking ACVR2 ligands by soluble activin receptor 2B (sACVR2B-Fc) on unfolded protein response (UPR), heat shock proteins (HSPs) and redox balance in a healthy mouse skeletal muscle. Second, we examined UPR, autophagy and redox balance with or without sACVR2B-Fc administration in muscle and liver of C26 tumor-bearing mice. The indicators of UPR and HSPs were not altered 1–2 days after a single sAC…
Transcriptional Upregulation of DNA Damage Response Genes in Bank Voles (Myodes glareolus) Inhabiting the Chernobyl Exclusion Zone
2018
Exposure to ionizing radiation (IR) from radionuclides released into the environment can damage DNA. An expected response to exposure to environmental radionuclides, therefore, is initiation of DNA damage response (DDR) pathways. Increased DNA damage is a characteristic of many organisms exposed to radionuclides but expression of DDR genes of wildlife inhabiting an area contaminated by radionuclides is poorly understood. We quantified expression of five central DDR genes Atm, Mre11, p53, Brca1, and p21 in the livers of the bank vole Myodes glareolus that inhabited areas within the Chernobyl Exclusion Zone (CEZ) that differed in levels of ambient radioactivity, and also from control areas ou…
The Role of Work-Nonwork Boundary Management in Work Stress Recovery
2016
The aim of the present study conducted among 1,106 Finnish employees was to identify boundary management profiles based on cross-role interruption behaviors from work to nonwork and from nonwork to work. Adopting a person-oriented approach through latent profile analysis, 5 profiles were identified: Work Guardians (21% of the employees), Nonwork Guardians (14%), Integrators (25%), Separators (18%), and an Intermediate Group (22%). We then examined differences between these profiles with respect to recovery experiences ( psychological detachment from work, relaxation, mastery experiences, and control during off-job time) and recovery outcomes (vigor and exhaustion). Work Guardians had the po…
Burnout-related ill-being at work : Associations between mindfulness and acceptance skills, worksite factors, and experienced well-being in life
2018
The aim of this paper was to investigate the associations between mindfulness and acceptance (MAA) skills and burnout-related ill-being at work (ILLB) after eliminating the impact of worksite (WS) and general well-being in life (WELLB) factors. The results were derived from data on employees (n = 168) of varying professional backgrounds, who experienced relatively high levels of burnout. Analyses were conducted using structural equation modelling (SEM) and the Cholesky decomposition method, since these allow for the investigation of multiple measures and multiple factors in relation to one another. In relation to ill-being at work, the analyses revealed a general MAA factor as well as a spe…
Examining the relationship between public speaking anxiety, distress tolerance and psychological flexibility
2020
Public speaking is an important skill for university students to learn and practice as they progress through education and into their careers. However, individuals often avoid facing public speaking, as they lack the skills to cope with the anxiety that arises when speaking in front of others. The current study aimed to investigate the relationship between public speaking anxiety, distress tolerance, and psychological flexibility. A sample of 95 college students completed psychological flexibility measures and self-ratings of public speaking anxiety before and after a public speaking challenge. A behavioral index of public speaking distress tolerance (i.e., speech duration) was also recorde…
A psychological flexibility -based intervention for burnout : A randomized controlled trial
2020
A novel eight-week program based on Acceptance and Commitment Therapy (ACT) principles was created to alleviate burnout-related ill-being and to enhance well-being. This randomized controlled trial investigated the effectiveness of the program and explored whether changes in psychological flexibility mediated the results of the intervention. The program consisted of structured weekly face-to-face group meetings and daily practices provided via a website. Employees from varying professional backgrounds with burnout (mean age = 47 years, 79% female), who all received usual treatment, 1 were randomized into control (TAU, n = 80, receiving no other support) and ACT + TAU intervention (n = 88, r…
Favouring emotional processing in improvisational music therapy through resonance frequency breathing: a single-case experimental study with a health…
2017
Resonance frequency breathing (RFB) is a form of slow breathing at around six breaths/min, whose immediate effects are to substantially increase heart rate variability (HRV) and to reduce stress levels. Since RFB has already been successfully used on its own to treat various emotional disorders, we wanted to evaluate its effect on emotional processing when used as a preparatory intervention in improvisational music therapy. To do so, we performed a single-subject experimental study with a healthy participant. We hypothesised that RFB would serve both as an emotional catalyst and emotional regulator, the actual outcome depending on the client’s current issues and needs. The study consisted o…